In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.

Promotor: T.H. Oosterkamp

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

The Microscopy Unit houses, maintains and coordinates most of the microscopy equipment of the IBL. The available equipment ranges from conventional light and fluorescence microscopes, to confocal laser scanning and electron microscopes. In addition, infrastructure is available for histology, including…

In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

We explore the possibilities to combine magnetic resonance techniques with atomic force microscopy together in a single microscope: the MRI-AFM, also called Magnetic Resonance Force Microscopy (MRFM).

Promotor: T. Schmidt

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

Promotor: Prof.dr. J.W.M. Frenken

Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

This is a yearly event where we move in one week from the physics of light through the composition of the microscope, fluorescence microscopy and end up with some image analysis All the lectures are backed by practicals to really put your obtained knowledge into practice

n this PhD thesis, the recombination of different atomic lattices in stacked 2D materials such as twisted bilayer graphene is studied. Using the different possibilities of Low-Energy Electron Microscopy (LEEM), the domain forming between the two atomic layers with small differences is studied.

The CMCB brings together a diverse range of unique expertise in microbial cell biology. Members of the CMCB investigate both model and non-model organisms, bacteria and archaea, pathogens and non-pathogens.

With a pioneering project like the quantum computer, it’s a good idea not to place all your bets on a single horse. In Leiden’s Quantum Optics research group, instead of working on a Majorana-based qubit, people are working on a qubit based on an ‘artificial atom’. If that becomes the basis of the quantum…

Electron microscopy has become an extremely important techniquein a wide variety of elds.

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…

The aim of this facility is to accelerate biomedical research by providing access to advanced light and electron microscopy and by sharing expertise about sample preparation, imaging modalities, data storage and image analysis.

Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.

Promotor: J.W.M. Frenken

This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

In this thesis we use Josephson and noise scanning tunneling microscopy for the study of conventional, unconventional (iron-based) and disordered superconductors. On the one hand, Josephson scanning tunneling microscopy allows us to directly visualize the superfluid density with high spatial resolut…

MRFM combines the principles of magnetic resonance and atomic force microscopy.

The dissertation describes TEM experiments on heterogeneous catalysts.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf

Some species of proteins which can form liquid-like condensates, also exhibit growth into fibers (or fibrils). One particularly interesting set of such proteins are those that are associated with neurodegeneration in which the fiber growth may be related to the pathological fibrils observed in disea…

Promotores: Prof.dr. C.U. Keller, Prof.dr. H.C. Gerritsen

Leiden physicist Milan Allan and his group have discovered an apparent paradox within a material that has zero electrical resistance. They measured trapped charges, while charges should in theory keep flowing in the absence of resistance. The discovery could provide a missing piece of one of the big…

By detecting the tiny forces between a micrometer sized magnet and the spins of hydrogen nuclei, we can do MRI with a volume resolution that is approximately 12 orders of magnitude better than a conventional MRI.  

Una Europa has identified and introduced six transversal themes as guiding principles for collaboration with the aim of supporting Una Europa staff and students to translate these themes into concrete actions.

High throughput microscopy

This book sheds new light on domestic forced migration by examining the experiences of American-born slave migrants from a comparative perspective.

This research focuses on the (Quantum) Dynamics (QD) of the reactive scattering of H2 from metal surfaces.

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Promotor: T. H. Oosterkamp

Establishing human induced pluripotent stem cell (iPSC) CRISPR-Cas9-based fluorescent reporter cell lines for NF-kB signalling. We will use this to enable studying the dynamic activation and downstream signalling of Toll-like receptor and cytokine signalling in iPSC-derived differentiated cells in a…

The purpose of this study was to investigate the formation and growth kinetics of complexes between proteins and oppositely charged polyelectrolytes.

We report new computational and experimental evidence of an efficient and astrochemically relevant formation route to formaldehyde (H2CO). This simplest carbonylic compound is central to the formation of complex organics in cold interstellar clouds and is generally regarded to be formed by the hydrogenation…

The research in my group addresses a range of topics related to quantum many-body physics.

The Netherlands Organisation for Scientific Research (NWO) has made a subsidy of 17 million euros available to further develop a Netherlands network for electron microscopy (NEMI). The network comprises five UMCs and eight universities, with Utrecht in the coordinating role. From Leiden, the Institute…

Promotor: Prof.dr. T. Schmidt

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

Promotor: B. van de Water

Promotor: B. van de Water