Can the venom of snakes, scorpions and other animals be sources of new antibiotics?

Leiden Biology student Lukas Kiefer has won the Unilever Research Prize 2018 for his research into efficient production of a new antibiotic. Kiefer: ‘I want to make biological medicines available to people in need.'

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

We aim to unravel the complex and intertwining regulatory systems that control development and antibiotic production in streptomycetes.

The adventure of iGEM Leiden has come to an end. The result: prizes for Best Therapeutic Project and Best Model, a gold medal, a successful crowdfunding campaign and of course their open-source research findings, which are available for the scientific community.

The CMCB comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC) and the Leiden University Medical Center (LUMC).

By carrying out fundamental research and providing excellent education, universities become a breeding ground for innovation and entrepreneurship.

Daniel Rozen (45), at the IBL since September 2012, uses bacteria in laboratory tests on experimental evolution to study the ecology and genetics of adaptation. His research has applied importance, as it reveals how bacteria may be induced to produce new antibiotics. Last January, Rozen received the…

This year, two Leiden master students will be awarded a KNMP Student Award. Both Wisse van Os and Jip Linthorst will receive 1,000 euros from the Royal Dutch Pharmacists Association (KNMP) as a reward for their excellent study results, motivation and commitment.

Can drugs that target host signaling pathways be used to eradicate antibiotic-resistant bacteria?

The Quantitative Pharmacology group headed by Coen van Hasselt focusses on the application of state-of-the-art quantitative pharmacological mathematical and statistical (pharmacometrics) modeling combined with systems biology modeling approaches, to characterize biomarkers for of disease and treatment…

The death of his grandfather in 1988 motivates Changsheng Wu to become a scientist. In 2016, he is awarded the C.J. Kok Jury Award for his thesis on novel antibiotics. Two years later, he will become a Professor at Shangdong University, at the age of 30 years.

Conference

Biotechnologist Boris Zacchetti enhanced the performances of Streptomyces bacteria, which are used to produce antibiotics and valuable enzymes. He discovered that certain genes are responsible for the formation of particles with highly different sizes, which has a negative impact on production performances.…

Nature is a never-ending source of inspiration for the researchers at the Institute of Biology Leiden (IBL). Based on a better fundamental understanding of nature, they are able to seek solutions in the area of health and biodiversity. The theme of IBL is ‘Harnessing biodiversity for health.’

Lecture

This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

PhD Defence

PhD Defence

Bachelor and Master students of all chemistry related studies are more than welcome to take part in our research activities. We have projects on design and synthesis of biologically relevant compounds within an ongoing research project. Supervision, following the apprentice/teacher model, is one of…

Microbial Sciences' contribution to the Evolution & Biodiversity research theme focuses on understanding how bacteria sense and respond to their environment, and how bacterial diversity and evolution is influenced by cooperative and antagonistic interactions taking place between microbes.

Leiden University and Leiden University Medical Center have joined the Netherlands Centre for One Health (NCOH), further strengthening the academic network in which such problems as antimicrobial resistance are studied.

After four years of hard work, the time has finally come: your thesis is finished. But who of your family and friends will ever read it? Biologist Lizah van der Aart decided to make a magazine for layman. 'It was precisely the explanation of the difficult, fundamental parts that gave me good tools for…

We investigate bacteria and fungi to understand their malicious or beneficial impact on food crops and their pathogenic or antibiotic role in human health.

Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?

The mission of our group is understanding how science communication works to improve the interaction between science and society.

We aim to develop a microfluidic platform that can parallelize testing the performance and characteristics of pure, mixed and environmental bacteriophage samples.

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

The central question of this Vici proposal is to investigate if, and how actinobacteria exploit life without a cell wall.

Though tuberculosis can be cured today, new resistant strains of the bacteria are becoming a growing problem in the medical world. Biologist Annemarie Meijer and her colleagues are studying resistance to this disease. Their research is already yielding several interesting clues that could help the development…

Lecture

PhD Defence

PhD Defence

PhD Defence

PhD Defence

Control of infectious diseases poses continuous challenges for human health.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Evolution & Biodiversity is one of the four research themes of the Institute of Biology Leiden.

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

We aim to develop a drug-delivery method based on the production of biomolecules directly at the target site.

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Promotor: Prof.dr. G.P. van Wezel

The research group Science Communication and Society has been physically within the Institute of Biology (IBL) since 2012 and has become a formal part of the institute in 2018. The mission of this group is understanding how science communication works to improve the interaction between science and s…

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

The effectiveness of antibiotics and the transport of the plant hormone auxin: both can be described using mathematical models. Sander Hille is a mathematician who works at the cutting edge of biology and mathematics. His interdisciplinary research is both fundamental and applied. When working on fundamental…