For hundreds of years, the island of Sri Lanka was a crucial stopover for people and goods in the Indian Ocean. For the Dutch East India Company, it was also a crossroads in the Indian Ocean slave trade. Slavery was present in multiple forms in Sri Lanka—then Ceylon—when the British conquered the island…

The structure of bacterial cells provides crucial clues about their interaction with their host. What are the key structural features of a bacterial cell that determine pathogenicity? What roles do these structures play in the life cycle, and how do they change during the infection process?

Microbial Sciences' contribution to the Bioactive Molecules research theme is to discover new bioactive molecules and enzymes and unravel their mechanisms of action, regulatory networks, and the (bio)synthetic pathways required for their production.

PhD Defence

A team of researchers at the Institute of Biology Leiden, in collaboration with scientists from Utrecht University, has discovered a novel approach to improve the production of antibiotics and enzymes in the soil bacteria Streptomycetes.

From Crisis to Critique

Can the venom of snakes, scorpions and other animals be sources of new antibiotics?

Artistic research has come of age, and with it the Orpheus Institute. Founded twenty years ago, the Institute’s purpose from the start has been to pursue research through the practice of musicians.

The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.

The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

The Persian Empire (539-330 BCE) was the first world empire in history. At its height, it united a territory stretching from present-day India to Libya - and it would take 2,000 years before significantly larger empires emerged in early modern Eurasia. Its size and power was revered by some, feared…

Fighting against cancer, antibiotic resistance and disposable plastics: Ahmed Ali, Fredj Ben Bdira, and Valerio Barbarossa receive a LUF grant for their innovative and socially relevant research. These grants for academic talent are often an important step towards grants by NWO and other grant insti…

Science, Leiden Academic Centre for Drug Research (LACDR)

We investigate bacteria and fungi to understand their malicious or beneficial impact on food crops and their pathogenic or antibiotic role in human health.

The opportunity to explore a new, exciting research topic. That is how Lennart Schada von Borzyskowski describes his successful application for the NWO XS grant. It comprises 50,000 euros, which the researcher from the Institute of Biology Leiden (IBL) will spend on investigating a more sustainable…

As part of the ZonMW Antibiotics resistance funding program, the LACDR cluster Systems Pharmacology was awarded €455.255 for a research project to develop novel clinical biomarkers for bacterial infections.

The Dutch organisation for scientific research NWO has announced that it will award an ENW-Klein grant to Marcellus Ubbink (LIC) for his research into the role of temperature in the evolution of enzymes. Sixteen grants have been awarded in total.

The fact that scientists are increasingly better able to access molecular cell and tissue data also brings with it a new challenge: how can scientists find the information they need for research among the vast amount of data available?

There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. Leiden University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP)…

By carrying out fundamental research and providing excellent education, universities become a breeding ground for innovation and entrepreneurship.

The central question of this Vici proposal is to investigate if, and how actinobacteria exploit life without a cell wall.

A full overview of MacBio PhD Theses.

Coen van Hasselt’s pharmacology group collaborated on a study recently published in the renowned Lancet Infectious Diseases. The international team mapped the antibiotic treatment of the life-threatening inflammatory reaction sepsis in newborn babies. They did this for low- and middle-income countries,…

Leiden physicists found a surprising interaction between electrons and a resist layer. The resist appears to charge and discharge due to incoming electrons. Publication in Physical Review Letters.

Een minuscuul cirkelvormig stukje DNA zorgt ervoor dat de darmbacterie Clostridioides difficile resistent raakt tegen een veelgebruikt antibioticum. Dat ontdekten wetenschappers van het Leids Universitair Medisch Centrum (LUMC) nadat artsen hen attendeerden op een patiënt met een moeilijk behandelbare…

Chaider Bamualim defended his thesis on 9 September 2015

Can drug screening for tuberculosis treatment be made more efficient?

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

'What do people do with snake venom?' That's the question 11-year-old Joep asked in Dutch TV show Willem Wever. Leiden Professor of Evolutionary developmental zoology and snake venom expert Michael Richardson answers the question in his laboratory.

Leiden University is partner of the Netherlands Centre for One Health (NCOH). This initiative brings together leading academic research institutes in the Netherlands in an open innovation network that responds to the theme: One Health. NCOH interviewed Doris van Bergeijk: PhD student of the project…

Actin and microtubules form cellular cytoskeletal network, which mediates cell shape, motility and proliferation and are key targets for cancer therapy. Changes in cytoskeletal organization correlate with proliferative capacity and invasiveness of cancer cells. These changes expectedly lead to altered…

How do harrowing war experiences affect different generations? Students have made a video about poignant family stories. They interviewed other students and writer Dubravka Ugrešić. The premiere of the film was on 4 May during the online Hour of Remembrance. Watch this online memorial.

Large numbers of Indonesians were active members of the resistance during the Second World War. One of them was Irawan Soejono, a student at Leiden University. He was shot dead on Boommarkt, during a raid on 13 January 1945. Seventy-five years later he was remembered in a small ceremony in the very…

Lecture

Science, Institute of Biology Leiden (IBL)

In Sci-Fi comic book Resist NOW!, wondrous adventures will illustrate possibilities to combat antimicrobial resistance. But the comic book will only be produced if enough money is raised to make the project into reality.

The study association of honours education SLHC established an international commission concerned with the closer involvement of international students in the Honours Community. The language of communication will become English where possible, and more upcoming activities will be organised in The Hague…

Using artificial intelligence to find new antibiotics. With that, researchers from Leiden University are nominated by magazine KIJK for the Best Tech-idea of 2021. From September 14 onwards people can vote to crown one of the nominees as the winner.

Professor Wim Willems of the Centre for Modern Urban Studies (MUS), together with Anne van Mourik, is researching the life of Ru Paré, the woman who saved 52 Jewish children during World War II.

Promotor: G.P. van Wezel

About nine million people worldwide contract tuberculosis each year. Research into new treatment for this disease has received fresh stimulus with more efficient techniques and a new understanding of how the tuberculosis bacteria works.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?

The fact that corona has created a wave of creativity is evident when walking around in the lab of pharmacologist Coen van Hasselt from the LACDR. Suddenly there were far fewer master's students permitted in the lab for their research. So Van Hasselt came up with smart solutions to enable lab work to…

Nature is a never-ending source of inspiration for the researchers at the Institute of Biology Leiden (IBL). Based on a better fundamental understanding of nature, they are able to seek solutions in the area of health and biodiversity. The theme of IBL is ‘Harnessing biodiversity for health.’