Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

The ultimate aim of the project is to find out whether there are such things as

The master’s specialisation Chemistry and Business Studies at Leiden University bridges science and business development by focusing on areas such as technology management, innovation, entrepeneurship, operations, and decision making.

PhD candidates carry out a programme of independent research and additional (limited) course work, culminating in production of a PhD thesis in typically 4 years.

The Biomedical Microscale Analytics group is led by Dr. Rawi Ramautar. In present-day metabolomics, and bioanalysis in general, the analytical toolbox used encounters difficulties for the analysis of limited amounts of biological samples. As a result, a significant number of crucial biomedical/clinical…

The database research community has made tremendous strides in developing powerful database engines that allow for efficient analytical query processing.

The two-year master’s programme Chemistry at Leiden Univerity offers a fundamental approach in finding tailored solutions for complex societal problems in human health and environmental issues. You can choose from four specialisations including Research in Chemistry and Chemistry an Business Studies…

The main goal of the THEOR CHEM group, headed by Prof. Geert-Jan Kroes, is to achieve the ability to predict the outcome of chemical reactions involving hydrogen from first principles. This goal is important in almost all fields of chemistry and in many fields of physics.

The philosopher and psychologist G.F. Stout was the teacher of Moore and Russell around 1894. This book shows that Stout's ideas have played a role in Moore and Russell's development from their early idealism towards analytic realism, where Stout's ideas often find their origin in early phenomenolog…

The ambition of the Analytical BioSciences and Metabolomics group led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies…

The master’s specialisation Chemistry and Education at Leiden University prepares students to teach the subject of chemistry to secondary school students. The programme comprises a one-year chemistry component, followed by an education component in the second year.

The Leiden Institute of Chemistry (LIC) is the basis for research and collaborations of the Leiden chemistry groups. Chemistry is the central science enabling a healthy future in a sustainable society. Chemistry researchers at Leiden University take a fundamental approach in finding tailored solutions…

The master’s specialisation Research in Chemistry at Leiden University offers research training founded on a profound theoretical basis. It prepares students who want to pursue a PhD degree in chemistry.

The Leiden Institute of Chemistry actively participates in several national research schools for MSc and PhD students. These schools are consortia that stimulate collaboration between research groups of the different participating Dutch universities. The research schools also offer advanced training…

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

LUMC Technology Focus Area (TFA) Data Analytics is een samenwerkingsverband van verschillende onderzoeksgroepen in het LUMC die nieuwe kwantitatieve en computationele methodologie ontwikkelen voor biomedisch en klinisch onderzoek.

The Supramolecular & Biomaterials Chemistry group of Prof. dr. Alexander Kros is active in the field of self-assembly of amphiphilic peptides and applying them in supramolecular chemistry.

Development of micro-scale analytical tools to be used to address relevant biomedical questions in the field of neuroscience, and other application areas intrinsically dealing with small sample amounts.

The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.

The mission in this research group, headed by Ad IJzerman, is to design and synthesize novel and better ligands for drug targets. Drug discovery is a lengthy but inspiring adventure. It is often an interplay between academic institutes and pharmaceutical industry, in which scientists at university develop…

The research aim of the Catalysis and Surface Chemistry group headed by Prof. Marc Koper is to probe and understand chemical reactions on well-defined, mostly single crystalline, surfaces at the molecular level.

This thesis explored the question whether Scrum methodology might function as an appropriate scaffold to enhance students’ learning and to support teachers in context-based secondary chemistry education.

The long term goal of the Biophysical Organic Chemistry/SSNMR group, headed by Prof. Huub de Groot, is to reach an understanding of structure, dynamics and functional mechanisms of membrane proteins and self-organized biological assemblies and to translate this knowledge into new concepts for nano-devices,…

The master’s specialisation Chemistry and Science Communication and Society at Leiden University bridges the gap between experts and the public by combining high quality research in chemistry with extensive training in science communication.

LIACS is a partner in RISE_SMA, an interdisciplinary, international network combining excellent scholars and practitioners to enable vigorous knowledge sharing and to develop solutions for contemporary challenges for Social Media Analytics (SMA).

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

Alexander Kros studies supramolecular systems in a biological environment. The unifying theme between the projects in my lab is specific molecular recognition, i.e. the intermolecular interaction between complementary molecules with high affinity and selectivity. Studying, imitating and dissecting processes…

Science, Leiden Academic Centre for Drug Research (LACDR), Leiden Institute of Chemistry (LIC)

Assistant Professor at the Department of Analytical Chemistry, Radboud University Nijmegen, the Netherlands

In the large gas clouds between the stars, chemical reactions take place under extreme conditions, giving rise to both small molecules, such as water and common salt, as well as large complex molecules that can serve as the building blocks of life. This is known as astrochemistry and it is something…

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

How are the building blocks of life formed?

Science, Leiden Academic Centre for Drug Research (LACDR)

PhD Defence

Demonstration experiments are a potentially powerful instrument to improve the micro-macro thinking of students in secondary education. Therefore we want to design a practical and generative approach to assist teachers to develop lessons with a demonstration experiment.

We are aiming to develop novel technologies to allow better sample preparation or coupling of analytical methods to (i) analyse ultra small samples, (ii) to analyse more metabolites in a quantitative manner and/or (iii) increase the sample throughput.

SMR can be used to measure the mass of adsorbed protein to nanoparticles with a high precision in the presence of free protein.

Promotor: Prof.dr. T. Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

The close interaction between organic chemi stry and biology goes back to the late 18th century, when the modern natural sciences began to take shape. After synthetic organic chemistry arose as a discipline, organic chemists almost immediately began to pursue the synthesis of naturally occurring compounds,…

Science, Leiden Institute of Chemistry (LIC)

Science

Science, Leiden Institute of Chemistry (LIC)

Laboratory, observation and modeling work on the dissociation of polycyclic aromatic hydrocarbons in interstellar environments and the formation of new molecular species through the fragmentation process.

Dr at CAMAG Laboratory, Switzerland

To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.