Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Following the conference of the 20th Austrian European Law Day in September 2021 at the University of Liechtenstein in Vaduz, the academic papers of the conference have now been published in book form. The book contributions include a chapter by Christa Tobler: Christa Tobler, 'Finally Brexit - Alternative…

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?

On May 23rd, Ernanda succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Ernanda on this great result.

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

Arabic and its Alternatives discusses the complicated relationships between language, religion and communal identities in the Middle East in the period following the First World War.

When deciding whether a Master's program is right for you, it is important to always compare other programs. Find out which one best fits you.

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Promotor: Roeland M.H. Merks

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen

Are predictive archaeological maps a reliable tool to play an important role in the spatial planning? One of the goals of this project was to develop best practices for the production and application of the models.

Existing work in probabilistic language modeling can be mostly divided into two categories:

Mathematical models of software systems enable characterizations, abstractions, simulations, and analysis of complex software during its development.

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Promotor: Prof.dr. E. Deprettere

The goal of this study is to systematically investigate how intonation (speech melody) is conveyed in whispered speech.

Main challenges in skin vaccination are overcoming the stratum corneum (SC) barrier and targeting the antigen presenting cells (APC) in the epidermis and the dermis.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

Arts and leisure, Arts and leisure

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

Behrouz Karoubi defended his thesis on 15 June 2016

... which build on self-regulation and stress-regulation theories and considers the modification of cognitions as a mediator of therapeutic change.

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Arts and leisure, Arts and leisure

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

In the near future oral polio vaccine (OPV) will be replaced by inactivated polio vaccine (IPV) as part of the eradication program of polio. For that reason, there is a need for substantial amount of safe and more affordable IPV for low-income countries. Bioneedles, which are biodegradable mini-implants,…

Can we find and commercialise new treatments for chronic disease that affect our ageing population? And how can we customise this research and development programme to the small but highly-developed Netherlands research economy?

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

Peter Grunwald

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.

ASLU 14

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

Classical mathematical models treat space and time as a continuum, while it is sometimes more useful to regard it as granular. Hupkes is studying what this means for a number of important patterns that are often found in computer calculations and in nature.

Science, Institute of Environmental Sciences (CML)

A research agenda

In this research project child language phonology is studied from the perspective of a psycholinguistic speech-production model and this model is in turn studied from the perspective of developmental phonology.

Promotor: Prof.dr. W.J.G.M. Peijnenburg, Co-promotor: Dr. ing. M.G. Vijver