1,605 search results for “alternative delivery” in the Public website
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Alternative delivery of a thermostable inactivated polio vaccine
In the near future oral polio vaccine (OPV) will be replaced by inactivated polio vaccine (IPV) as part of the eradication program of polio. For that reason, there is a need for substantial amount of safe and more affordable IPV for low-income countries. Bioneedles, which are biodegradable mini-implants,…
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Novel formulations and delivery strategies for inactivated polio vaccines: new routes with benefits
This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.
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Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
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Zebrafish Delivery
Is there a sufficiently large market for drug screening and testing in Zebrafish larvae using membrane fusion?
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Vaccine delivery
Vaccination via the skin or the mucosae
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PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
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Animal models for cutaneous vaccine delivery
Main challenges in skin vaccination are overcoming the stratum corneum (SC) barrier and targeting the antigen presenting cells (APC) in the epidermis and the dermis.
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Buccal and sublingual vaccine delivery
Because of their large surface area and immunological competence, mucosal tissues are attractive administration and target sites for vaccination.
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Delivery of Biotherapeutics
The Delivery of Biotherapeutics research group is led by Prof. Matthias Barz and focusses on the synthesis and characterization of polypept(o)ids and their application in nanomedicine to improve existing therapies or enable novel diagnostic or therapeutic approaches.
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Microneedle-based drug and vaccine delivery via nanoporous microneedle arrays
In the literature, several types of microneedles have been extensively described. However, porous microneedle arrays only received minimal attention. Hence, only little is known about drug delivery via these microneedles. However, porous microneedle arrays may have potential for future microneedle-based…
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PhD candidate , Lysosomal delivery of intracellular pathogens
Science, Institute of Biology Leiden (IBL)
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Minipigs as an Animal Model for Dermal Vaccine Delivery
Appropriate animal models for intradermal vaccine delivery are scarce. Given the high similarity of their skin anatomy to that of humans, minipigs may be a suitable model for dermal vaccine delivery.
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Reactive Copolypept(o)ides as Novel Material for Systemic siRNA Delivery
The aim of the project is the development of polypept(o)ide-based delivery systems to use siRNA as systemic applicated therapeutic agent against e.g. solid tumors
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Liposomes as delivery system for allergen-specific immunotherapy
In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.
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Intradermal delivery of nanoparticulate vaccines using coated and hollow microneedles
In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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In vitro and in vivo delivery of functionalized nanoparticles via coiled-coil interactions
Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn
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An efficient membrane biophysical tool and its application in drug delivery studies
Promotor: A. Kros
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Alternative programs
When deciding whether a Master's programme is right for you, it is important to always compare other programmes. Find out which one best fits you.
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Alternative programmes
When deciding whether a Master's programme is right for you, it is important to always compare other programmes. Find out which one best fits you.
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Elastin-like polypeptide micelles for vaccine delivery
PhD Defence
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Phrasal alternation in Kerinci
On May 23rd, Ernanda succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Ernanda on this great result.
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Supramolecular materials: from biosensors to cell delivery devices
The group of Dr. Roxanne Kieltyka designs and synthesizes molecules that self-assemble into polymeric materials using specific non-covalent interactions. These substrates can be used for numerous applications in medicine ranging from disease detection to cell delivery depending on the (bio)molecular…
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Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model
Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model
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Arabic and its Alternatives
Arabic and its Alternatives discusses the complicated relationships between language, religion and communal identities in the Middle East in the period following the First World War.
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Membrane Fusion Mediated Intracellular Delivery of Lipid Bilayer Coated Mesoporous Silica Nanoparticles
Alexander Kros and co-workers describe how mesoporous silica nanoparticles (MSNs) are delivered into cells via membrane fusion thereby omitting endocytosis pathways. Fusion is induced by a pair of complementary coiled-coil lipopeptides inserted into the membrane of cells and in the bilayer of lipid-coated…
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Cas-induced targeted mutagenesis with Agrobacterium mediated protein delivery
The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.
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Alternative Master's programs
When deciding whether a Master's program is right for you, it is important to always compare other programs. Find out which one best fits you.
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Are Citizens More Negative About Failing Service Delivery by Public Than Private Organizations?
Petra van der Bekerom, Joris van der Voet, and Johan Christensen, three assistant professors at Leiden University, conducted a large-scale survey experiment about whether citizens are more negative about failing service delivery than private organizations.
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Improving citizens’ participation in public service delivery: the possibilities of data dashboards
Data science offers exciting new instruments for governments to reach out to citizens, for example by using data-driven information channels, providing real-time simulations, or personalizing services based on citizen data. At the same time, the possibilities and use of data science methods can have…
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CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responses
Dendritic cells (DC) play a prominent role in the priming of CD8(+) T cells. Vaccination is a promising treatment to boost tumor-specific CD8(+) T cells which is crucially dependent on adequate delivery of the vaccine to DC.
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Design of Athero-Protective Vaccines; Novel Vaccine Formulations and Alternative Routes of Administration
Atherosclerosis is a chronic inflammatory disease affecting millions of people world-wide.
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Development of a universal delivery system for tailor-made cancer vaccines
The potential of liposomal cancer vaccines
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Formulation of influenza T cell peptides: In search of a universal influenza vaccine
Promotoren: G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij
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Construction of alternative Humanities Campus is feasible
Leiden University can build an alternative Humanities Campus on its own available land at the current location in the city. This is the conclusion of a feasibility study and is what the mayor and aldermen of Leiden write in a letter to the city council.
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Prosody in whispered speech: retrieving alternative cues to pitch
The goal of this study is to systematically investigate how intonation (speech melody) is conveyed in whispered speech.
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Parameter optimization toward optimal microneedle-based dermal vaccination
Microneedle-based vaccination has several advantages over vaccination by using conventional hypodermic needles.
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Replacing the needle and syringe for vaccine administration
Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra
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Drug Delivery to the Brain
This book describes the different approaches for drug delivery to the brain with an emphasis on the physiology of the blood-brain barrier (BBB) and the governing principles and concepts for drug delivery across the BBB
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Ovalbumin coated pH-sensitive microneedle arrays effectively induce ovalbumin-specific antibody and T-cell responses in mice
The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…
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New professor of Biotherapeutics Delivery at LACDR
Matthias Barz has been appointed full Professor of Biotherapeutics Delivery at the Leiden Academic Centre for Drug Research (LACDR).
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis
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Colonialism and Slavery: An Alternative History of the Port City of Rotterdam
Unlike most city histories, this book focuses exclusively on the city’s connections with colonialism and slavery.
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Alexander Kros
Science
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BIOMOT: Motivational strength of ecosystem services and alternative ways to express the value of biodiversity
Do sustainability values play a role in motivating people to act for biodiversity in successful projects and in successful leadership action? And how could these values be incorporated in current economic valuation methods?
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Gideon Kersten
Science
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Founding an Inclusive Space: Legacies of Alternative Archiving Practices in the Netherlands, Germany and the United Kingdom
The project ‘Founding an Inclusive Space’ investigates the histories of various LGBT+ archives in the Netherlands, Germany and the United Kingdom.
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Collective alternative logistics through digitalisation
What are the new challenges for collective organisations in the logistic sector? On 25 November 2021, Raquel Alquézar Crusellas has visited the ERC group to exchange insights about her new research about collective organisations among delivery riders in Europe.
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Arabic and its alternatives: Religious minorities in the formative years of the modern Middle East (1920-1950)
This project aims to revisit the ways in which religious minorities in the Middle East participated in, contributed to, and opposed the Arab nationalism of the post-war years, when the British and French ruled the region via the Mandates. Research question: How did religious minorities in the Middle…