To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

Princeton University has officially launched its website, MAFE: Middle Ages for Educators. MAFE is aimed at university and secondary students and educators and, more broadly, at anyone who is interested in studying, teaching, or learning more about Late Antiquity and the Middle Ages.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

The Australian Research Council funded a truly ‘global archaeology’ project comparing the archaeologies of southwest Tasmania and southwest France during the last Ice Age.

Prof. David Fontijn’s Economies of Destruction team was invited by Museum Midtjylland to participate in this year’s excavation in Boest, Jutland (Denmark). The exceptional site of Boest includes burial mounds, an alignment and depositions, consisting of axes, spearheads and rings, dating to the Bronze…

Mapping of bacterial genomes to combat infectious diseases

A Selection of the Poems of Sir Constantijn Huygens (1596-1687) was published in July 2015, edited and translated by Adriaan van der Weel and Peter Davidson.

Alireza Mashaghi and his research team have created a new framework to understand shapes of proteins and DNA. With this framework, many diseases can be understood better.

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax

From 1 September, the Leiden University Medical Center (LUMC) will be offering a fully funded regular Master’s programme in Vitality and Ageing.

How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?

How can Staphylococcus aureus bacteria subvert the host immune system?

On the 6th of July, wood specialists, members of the canoe club Natsec, a professional boat builder, volunteers of the Vlaardingen Broekpolder and students and staff of the Faculty of Archaeology of the Leiden University gathered on the waterfront in Vlaardingen. Two reconstructions of prehistoric canoes…

TRANSAUTOPHAGY is a European COST action to promote multidisciplinary research on autophagy and translation of knowledge to applications.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Large-scale forest fires started by prehistoric hunter-gatherers are probably the reason why Europe is not more densely forested. This is the finding of an international team, including climate researcher Professor Jed Kaplan of the University of Lausanne and archaeologist Professor Jan Kolen of Leiden…

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

People in the Early Bonze Age used bronze artefacts as a means of payment. This is the conclusion reached by archaeologists Maikel Kuijpers and Catalin Popa in a PLOS ONE article published on 20 January. The discovery led to a surge of media reports.

How can cell wall engineering approaches be used to improve streptomycetes for industry to make new antibiotics?

Female and male songbirds sing equally elaborate songs in some species, but in others, females do not sing like males or not at all. How did such pronounced differences in male and female communication evolve?

We aim to unravel the complex and intertwining regulatory systems that control development and antibiotic production in streptomycetes.

What can the composition and arrangement of urnfield graves tell us about the social and ideological believes of the urnfield period societies?

Fake news about ‘patient zero’ and hyperbolic headlines warning about the ‘yellow peril.’ Leiden researchers have spotted fake news galore about coronavirus as well as racial stereotypes about the Chinese. How harmful is this?

City dwellers in the Middle Ages were probably no worse off than people living in villages. Both groups had very different health risks, is Rachel Schats' conclusion from her research on bone material. PhD defence 3 November.

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

Professors Simcha Jong (Leiden University) and Rifat Atun (Harvard University) convened an exploratory seminar to discuss challenges for health systems in realising the potential of precision medicine at Harvard University’s Radcliffe Institute for Advanced Studies in Cambridge, MA on 17 April 2017.

We aim to develop a microfluidic platform that can parallelize testing the performance and characteristics of pure, mixed and environmental bacteriophage samples.

Bronze Age settlement sites in the Dutch river area (c. 2000-800 BC)

Want to find out more about our master’s programme? Or are you wondering what questions are asked during the Q&A about the content or careers of Vitality and Ageing? Than watching our webinar would suit your curiosity!

To bring the academic field closer to the professionals working in the field of Vitality and Ageing, the master’s Vitality and Ageing organises its first network event on November 22nd at the Boerhaave Plein of the LUMC.

PhD Defence

A central and much debated topic in the study of language acquisition concerns the nature of the learning mechanisms that are required. Are the computational and learning mechanisms that guide learning about language structure special and specific to language or humans?

Professor David Fontijn is fascinated by the question why people destroy objects that are dear to them. It is a phenomenon that you find everywhere in the world, gaining particular strength in the European Bronze Age. Fontijn wrote a book on this ‘economy of destruction’, published by Routledge.

Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…

Alireza Mashaghi from the Leiden Academic Centre for Drug Research (LACDR) will use state-of-the-art technology to investigate proteins that play a role in muscular dystrophy. His goal is to provide new insights for designing novel therapeutic strategies in the future. To accomplish this, Mashaghi receives…

Early cave paintings of hunting scenes may give the impression our Stone Age ancestors lived mainly on chunks of meat, but plants were just as key to their survival. Plants rich in starch helped early humans to thrive even at the height of the last Ice Age, Leiden archaeologist Amanda Henry tells Horizon…

The Faculty of Archaeology has appointed Dr Marie Louise Sørensen as Professor in Bronze Age Studies in the European Prehistory research group from 1st September 2012. Prof. Sørensen is a Reader in Archaeology at the University of Cambridge (Fellow of Jesus College).

Cultural biographies of persons, objects and 'natural' places in the Bronze Age of the Southern Netherlands, c. 2300-600 BC.

Master Vitality and Ageing’s (V&A) alumnus Willeke Ravensbergen conducted for her master’s thesis research on the impact of combinations of future trends on healthcare utilisation of older people in collaboration with the National Institute for Public Health and the Environment (Rijksinstituut voor…

The Middle Ages are becoming increasingly more popular: just look at the popularity of such ‘medievalist’ TV series as Game of Thrones and Vikings, and let’s not forget popular re-enactments of medieval battles. Leiden University is home to many specialists of this fascinating period and this new blog…

When mosquito eggs hatch in nutrient-rich water, the mosquitoes are larger and they can also fly further. That is the first conclusion of a study from by the Netherlands Centre for One Health (NCOH) by PhD-student Sam Boerlijst.