3,304 search results for “aging alzheimer s disease” in the Public website
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Leiden: The scene of the Zebrafish Disease Models conference 2018
In July, 2018, the Institute of Biology Leiden hosted the 11th conference of the Zebrafish Disease Models Society (ZDMS), an international association dedicated to the advancement of basic and clinical research using zebrafish disease models. More than 350 researchers from all over the world gathered…
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Synthesis and application of glycans unique to S. Mansoni
Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.
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‘Coeliac disease diagnosis is often overlooked or delayed’
Although coeliac disease, an autoimmune disorder that makes you gluten intolerant, occurs in 1% of the population, its diagnosis is often delayed or completely overlooked. To prevent health problems, this must change. That is what Professor of Paediatrics Luisa Mearin said at her inaugural lecture on…
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Two-pronged attack on infectious diseases
A combination of two potential drugs gives hope of a 'super blockage' of an over-active immune system, Leiden researchers report in Nature. The breakthrough came from the crystallisation of a membrane protein.
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The Ussen Project
The first decade of excavations at Oss
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10 million for research into disease transmission by mosquitoes
How can the Netherlands be better prepared for infectious diseases transmitted by mosquitoes. The Dutch Research Council (NWO) has awarded almost 9 million euros for this research. Maarten Schrama from the Institute of Environmental Sciences CML coordinates the input of Leiden University within the…
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NWO grant for super fast analysis of disease progression
New funding allows IBL-researcher Herman Spaink to purchase a measurement device for more studies on human diseases such as cancer and tuberculosis using zebrafish as the model system.
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Decomposing tears in order to detect Dry Eye Disease
By measuring proteins in tears, ophthalmologists can more easily diagnose dry eyes (Dry Eye Disease). Peter Raus, a Belgian ophthalmologist and PhD student at the Institute of Biology Leiden, developed a new method for protein determination in tear fluid. The technique is also promising for the early…
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The comparative biology of language learning
A theoretical project on the insights gained by human (including infant), nonhuman animal and computational studies on artificial grammar learning; identifying the critical questions for future research by developing novel experimental and computational approaches to address these issues.
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Lecture Simone van der Hof on age verification and age appropriate design
On 6 October 2021, Simone van der Hof gave a lecture on age verification and age appropriate design.
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Digging into stone age secrets
Archaeologist Dr Gerrit Dusseldorp's research project was covered by a South African newspaper. Dusseldorp and his team investigate the evolution of human behaviour through artefacts dug up in South African caves.
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'Masterchefs from the Middle Ages'
Joanita Vroom, Associate Professor Archaeology, regularly tries out old recipes, together with a group of Archaeology students. 'You really need to love garlic.'
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Monica Varela Alvarez
Science
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Hans Aerts
Science
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LED3 Drug Discovery Case Studies
To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.
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Collaborating on big data to unravel disease processes
Patients with the same illness often receive the same treatment, even if the cause of the illness is different for each person. This represents a new step towards ultimately being able to offer every patient more personalised treatment.
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Changing enzymes for clean energy and disease prevention
They can play a role in metabolic disorders and can break down tough plant fibers: β-glycosidases are enzymes that play many roles in nature. Fredj Ben Bdira changed these enzymes in order to enhance the production of clean energy and to improve the treatment of patients with metabolic diseases.
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Blogging about the Middle Ages: love magic, face masks and video games
Three years ago, on 13 October 2017, the Leiden Medievalists Blog was established. In their blogs, Leiden researchers from all disciplines talk about the Middle Ages in a fun and interesting way. Editors Jip Barreveld, Marlisa den Hartog and Thijs Porck talk about the blog and why the Middle Ages are…
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The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.
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S Scanner
Faculteit der Sociale Wetenschappen
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Wild West Frisia
The role of domestic and wild resource exploitation in Bronze Age subsistence
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Discantare Super Planum Cantum- New Approaches to Vocal Polyphonic Improvisation 1300-1470
Today’s performances of medieval polyphony have a lot in common with those of other ‘classical’ or ‘early’ music. Ensembles perform pieces written by known or lesser known composers, which the listener can revisit by listening to recordings or reading a score.
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Launch Middle Ages for Educators (MAFE)
Princeton University has officially launched its website, MAFE: Middle Ages for Educators. MAFE is aimed at university and secondary students and educators and, more broadly, at anyone who is interested in studying, teaching, or learning more about Late Antiquity and the Middle Ages.
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Claiming Ancient Rome’s Heritage: Translatio imperii as an Anchoring Device in the Neo-Latin Poetry of Florence in the Age of Lorenzo de’ Medici
In Renaissance Florence, humanists wrote Latin poems fashioning their city as the new Rome, and members of the Medici family as Roman rulers. How can we explain this practice?
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Thrips resistance in strawberry: more fruits with less pesticides
Can thrips resistance in strawberry be explained based on secondary metabolite profiles and plant morphological traits?
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Streptomyces as cell factories
We aim to engineer streptomycetes to fully exploit their potential for natural product productions, by a rational design and evolution approach.
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Regulation of vegetative development and life history strategy in plants
How is vegetative development regulated in plants and how does this affect a plant’s life history strategy?
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New project on the last Ice Age
The Australian Research Council funded a truly ‘global archaeology’ project comparing the archaeologies of southwest Tasmania and southwest France during the last Ice Age.
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Boest: Bronze Age at its best
Prof. David Fontijn’s Economies of Destruction team was invited by Museum Midtjylland to participate in this year’s excavation in Boest, Jutland (Denmark). The exceptional site of Boest includes burial mounds, an alignment and depositions, consisting of axes, spearheads and rings, dating to the Bronze…
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Transfer of "goods" from plants to humans: Fundamental and applied biochemical investigations on retaining glycosidases
The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.
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Maia Casna investigates respiratory disease in the past with an NWO PhD in the Humanities grant
Every year, an NWO PhD in the Humanities grant is awarded to a prospective PhD candidate at the Faculty of Archaeology. This year, the grant went to Maia Casna, enabling her to study respiratory disease in the past. ‘My hypothesis is that the rapid formation of cities in the medieval Netherlands, must…
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A Selection of the Poems of Sir Constantijn Huygens (1596-1687)
A Selection of the Poems of Sir Constantijn Huygens (1596-1687) was published in July 2015, edited and translated by Adriaan van der Weel and Peter Davidson.
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Mapping of bacterial genomes to combat infectious diseases
Mapping of bacterial genomes to combat infectious diseases
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Shaping proteins to understand chaperone-related diseases
Alireza Mashaghi and his research team have created a new framework to understand shapes of proteins and DNA. With this framework, many diseases can be understood better.
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Development of Comprehensive and High-throughput metabolomics techniques
A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…
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Innate immune modulation in atherosclerosis and vascular
Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax
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LUMC Master’s programme in Vitality and Ageing updated and fully funded from 1 September
From 1 September, the Leiden University Medical Center (LUMC) will be offering a fully funded regular Master’s programme in Vitality and Ageing.
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First trials with Iron age dugout canoe
On the 6th of July, wood specialists, members of the canoe club Natsec, a professional boat builder, volunteers of the Vlaardingen Broekpolder and students and staff of the Faculty of Archaeology of the Leiden University gathered on the waterfront in Vlaardingen. Two reconstructions of prehistoric canoes…
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Wenyu Wan
Faculteit der Sociale Wetenschappen
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FishForPharma: Training network on zebrafish infection models for pharmaceutical screens
How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?
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Staphylomics: Identifying host factors involved in staphylococcal infection
How can Staphylococcus aureus bacteria subvert the host immune system?
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S van der Vliet
Faculty of Humanities
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Ice Age hunters destroyed forests throughout Europe
Large-scale forest fires started by prehistoric hunter-gatherers are probably the reason why Europe is not more densely forested. This is the finding of an international team, including climate researcher Professor Jed Kaplan of the University of Lausanne and archaeologist Professor Jan Kolen of Leiden…
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TRANSAUTOPHAGY: European network for multidisciplinary research and translation of autophagy knowledge
TRANSAUTOPHAGY is a European COST action to promote multidisciplinary research on autophagy and translation of knowledge to applications.
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Dyslipidemia, metabolism and autophagy: antigen-independent modulation of T cells in atherosclerosis
Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.
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archaeologists in international media on early form of money in the Bronze Age
People in the Early Bonze Age used bronze artefacts as a means of payment. This is the conclusion reached by archaeologists Maikel Kuijpers and Catalin Popa in a PLOS ONE article published on 20 January. The discovery led to a surge of media reports.
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‘City dwellers in Middle Ages no worse off than village dwellers’
City dwellers in the Middle Ages were probably no worse off than people living in villages. Both groups had very different health risks, is Rachel Schats' conclusion from her research on bone material. PhD defence 3 November.
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‘Fantasies about coronavirus are more contagious than the disease itself’
Fake news about ‘patient zero’ and hyperbolic headlines warning about the ‘yellow peril.’ Leiden researchers have spotted fake news galore about coronavirus as well as racial stereotypes about the Chinese. How harmful is this?
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Why not sing? Reconstructing the evolution of female and male bird song
Female and male songbirds sing equally elaborate songs in some species, but in others, females do not sing like males or not at all. How did such pronounced differences in male and female communication evolve?
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Less is more: reduced mycelial heterogeneity for improved production of enzymes and antibiotics
How can cell wall engineering approaches be used to improve streptomycetes for industry to make new antibiotics?