In July, 2018, the Institute of Biology Leiden hosted the 11th conference of the Zebrafish Disease Models Society (ZDMS), an international association dedicated to the advancement of basic and clinical research using zebrafish disease models. More than 350 researchers from all over the world gathered…

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Although coeliac disease, an autoimmune disorder that makes you gluten intolerant, occurs in 1% of the population, its diagnosis is often delayed or completely overlooked. To prevent health problems, this must change. That is what Professor of Paediatrics Luisa Mearin said at her inaugural lecture on…

A combination of two potential drugs gives hope of a 'super blockage' of an over-active immune system, Leiden researchers report in Nature. The breakthrough came from the crystallisation of a membrane protein.

The first decade of excavations at Oss

How can the Netherlands be better prepared for infectious diseases transmitted by mosquitoes. The Dutch Research Council (NWO) has awarded almost 9 million euros for this research. Maarten Schrama from the Institute of Environmental Sciences CML coordinates the input of Leiden University within the…

New funding allows IBL-researcher Herman Spaink to purchase a measurement device for more studies on human diseases such as cancer and tuberculosis using zebrafish as the model system.

By measuring proteins in tears, ophthalmologists can more easily diagnose dry eyes (Dry Eye Disease). Peter Raus, a Belgian ophthalmologist and PhD student at the Institute of Biology Leiden, developed a new method for protein determination in tear fluid. The technique is also promising for the early…

A theoretical project on the insights gained by human (including infant), nonhuman animal and computational studies on artificial grammar learning; identifying the critical questions for future research by developing novel experimental and computational approaches to address these issues.

On 6 October 2021, Simone van der Hof gave a lecture on age verification and age appropriate design.

Archaeologist Dr Gerrit Dusseldorp's research project was covered by a South African newspaper. Dusseldorp and his team investigate the evolution of human behaviour through artefacts dug up in South African caves.

Joanita Vroom, Associate Professor Archaeology, regularly tries out old recipes, together with a group of Archaeology students. 'You really need to love garlic.'

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

Patients with the same illness often receive the same treatment, even if the cause of the illness is different for each person. This represents a new step towards ultimately being able to offer every patient more personalised treatment.

They can play a role in metabolic disorders and can break down tough plant fibers: β-glycosidases are enzymes that play many roles in nature. Fredj Ben Bdira changed these enzymes in order to enhance the production of clean energy and to improve the treatment of patients with metabolic diseases.

Three years ago, on 13 October 2017, the Leiden Medievalists Blog was established. In their blogs, Leiden researchers from all disciplines talk about the Middle Ages in a fun and interesting way. Editors Jip Barreveld, Marlisa den Hartog and Thijs Porck talk about the blog and why the Middle Ages are…

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

The role of domestic and wild resource exploitation in Bronze Age subsistence

Today’s performances of medieval polyphony have a lot in common with those of other ‘classical’ or ‘early’ music. Ensembles perform pieces written by known or lesser known composers, which the listener can revisit by listening to recordings or reading a score.

Princeton University has officially launched its website, MAFE: Middle Ages for Educators. MAFE is aimed at university and secondary students and educators and, more broadly, at anyone who is interested in studying, teaching, or learning more about Late Antiquity and the Middle Ages.

In Renaissance Florence, humanists wrote Latin poems fashioning their city as the new Rome, and members of the Medici family as Roman rulers. How can we explain this practice?

Can thrips resistance in strawberry be explained based on secondary metabolite profiles and plant morphological traits?

We aim to engineer streptomycetes to fully exploit their potential for natural product productions, by a rational design and evolution approach.

How is vegetative development regulated in plants and how does this affect a plant’s life history strategy?

The Australian Research Council funded a truly ‘global archaeology’ project comparing the archaeologies of southwest Tasmania and southwest France during the last Ice Age.

Prof. David Fontijn’s Economies of Destruction team was invited by Museum Midtjylland to participate in this year’s excavation in Boest, Jutland (Denmark). The exceptional site of Boest includes burial mounds, an alignment and depositions, consisting of axes, spearheads and rings, dating to the Bronze…

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Every year, an NWO PhD in the Humanities grant is awarded to a prospective PhD candidate at the Faculty of Archaeology. This year, the grant went to Maia Casna, enabling her to study respiratory disease in the past. ‘My hypothesis is that the rapid formation of cities in the medieval Netherlands, must…

A Selection of the Poems of Sir Constantijn Huygens (1596-1687) was published in July 2015, edited and translated by Adriaan van der Weel and Peter Davidson.

Mapping of bacterial genomes to combat infectious diseases

Alireza Mashaghi and his research team have created a new framework to understand shapes of proteins and DNA. With this framework, many diseases can be understood better.

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax

From 1 September, the Leiden University Medical Center (LUMC) will be offering a fully funded regular Master’s programme in Vitality and Ageing.

On the 6th of July, wood specialists, members of the canoe club Natsec, a professional boat builder, volunteers of the Vlaardingen Broekpolder and students and staff of the Faculty of Archaeology of the Leiden University gathered on the waterfront in Vlaardingen. Two reconstructions of prehistoric canoes…

How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?

How can Staphylococcus aureus bacteria subvert the host immune system?

Large-scale forest fires started by prehistoric hunter-gatherers are probably the reason why Europe is not more densely forested. This is the finding of an international team, including climate researcher Professor Jed Kaplan of the University of Lausanne and archaeologist Professor Jan Kolen of Leiden…

TRANSAUTOPHAGY is a European COST action to promote multidisciplinary research on autophagy and translation of knowledge to applications.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

People in the Early Bonze Age used bronze artefacts as a means of payment. This is the conclusion reached by archaeologists Maikel Kuijpers and Catalin Popa in a PLOS ONE article published on 20 January. The discovery led to a surge of media reports.

City dwellers in the Middle Ages were probably no worse off than people living in villages. Both groups had very different health risks, is Rachel Schats' conclusion from her research on bone material. PhD defence 3 November.

Fake news about ‘patient zero’ and hyperbolic headlines warning about the ‘yellow peril.’ Leiden researchers have spotted fake news galore about coronavirus as well as racial stereotypes about the Chinese. How harmful is this?

Female and male songbirds sing equally elaborate songs in some species, but in others, females do not sing like males or not at all. How did such pronounced differences in male and female communication evolve?

How can cell wall engineering approaches be used to improve streptomycetes for industry to make new antibiotics?