5,288 search results for “aging alzheimer s disease” in the Public website
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Magnetic Resonance Microimaging of Alzheimer's Disease
Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…
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Monitoring Alzheimer's disease in transgenic mice with ultra high field magnetic resonance imaging
Promotor: H.J.M. de Groot, Co-Promotor: A. Alia
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Predicting early Alzheimer's disease stage in human
A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).
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Natural and non-natural factors influencing Alzheimer´s Aβ
Promotor: Prof.dr. J.P. Abrahams
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CoSTREAM: Understanding Stroke and Alzheimer
The Horizon 2020 project CoSTREAM aims to improve our understanding of the co-occurrence of stroke and Alzheimer’s disease. It has long been known that both diseases share underlying causes, but their exact interaction or link is not fully understood. CoSTREAM combines multiple factors to identify and…
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Using smartphone behaviour to understand healthy ageing and neurological disease
Leiden University researchers and their collaborators report the development of new research frameworks that use day-to-day smartphone behavior gathered from a large sample of healthy people to help understand aging, and how aging alters with epilepsy and stroke. These reports occupy two back-to-back…
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A game of Mastermind to unravel Alzheimer’s disease
In order to better understand the course of Alzheimer’s disease, Frédérique Kok believes that a strategic and structured approach is needed: the Mastermind research approach. With her LUF grant, Kok wants to generate high-quality data to build a mathematical model that can recognize the onset of the…
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New project funded to study Alzheimer's disease
Researchers from Leiden University will develop a new approach to study the biomarkers of Alzeimer’s disease. This approach focusses on the molecular messengers of the cells. The project, led by Thomas Hankemeier and coordinated by Yuliya Shakalisava (Leiden Academic Centre for Drug Research, LACDR),…
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Inhibiting protein production potentially a weapon against Alzheimer’s
Inhibiting specific protein production in the human body can serve as a crucial weapon in the fight against Alzheimer's, Eline van Maanen believes. PhD defence 23 November.
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New Alzheimer’s research method uses muons
Alzheimer’s disease is the most common form of dementia. This makes fundamental research on the precise cause of the illness of vital importance. One of the possible suspects is a certain protein filled with iron. Leiden physicist Lucia Bossoni (LION/LUMC) has now developed a new way of investigating…
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Pharmacological resting-state fMRI in aging and dementia
How can we implement the technique of pharmacological resting-state fMRI to improve the diagnosis of dementia?
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Reversing cardiovascular diseases
How can the development of constrictions in the blood vessels be reversed?
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Ageing
As a result of an increased life expectancy, more people suffer from chronic diseases and discomfort. Elderly patients may have multiple diseases simultaneously, with concomitant multiple medications.
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Physicists link specific iron forms to Alzheimer’s
There have been indications for decades that there is a link between increased iron levels in the brain and Alzheimer’s disease. Leiden physicists find this connection as well, thereby now making a distinction between different forms of iron. They identify specific iron forms that increase in Alzheimer’s…
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metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
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Development & Disease
Development & Disease is one of the four research themes of the Institute of Biology Leiden.
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Putting a spin on it: amyloid aggregation from oligomers to fibrils
This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.
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Aging and Immunity
The Aging and Immunity group is led by Dr. Amanda Foks. In this group we aim to investigate how aged immune cells contribute to atherosclerosis and identify novel therapeutic targets and strategies to extend health span and inhibit cardiovascular disease.
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New method to catch notorious Alzheimer protein
A new biophysical technique enables scientists to study the behavior of Aβ-peptide. This protein is known to play a role in Alzheimer’s, but for effective medication we need to know exactly what it does. Publication in Journal of Biological Physics on March 16th.
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Systems pharmacology of the amyloid cascade
According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).
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Novel detection method for iron in Alzheimer’s brain
For many years, scientists have observed a correlation between Alzheimer’s disease and a surplus of iron in the brain. However, a causal link between the two has not been proven yet. We lack knowledge concerning the specific form of iron that is involved in the development of neurodegenerative diseases.…
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Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.
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Topic: Aging and neuropsychological rehabilitation
Cognitive decline (amongst other problems with attention, concentration, memory) is a common symptom in patients with a variety of brain disorders and has been related to healthy ageing as well. People suffering from cognitive deficits are often significantly hampered in their day-to-day functioning…
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Topic: Self-management in chronic diseases
Having a chronic somatic condition can result in a variety of impairments in patients’ daily lives, including not only physical complaints such as pain, itch, and fatigue, but also problems of negative mood and impairments in social relationships. Next to disease characteristics, individual difference…
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Lipid signaling in brain diseases
Multiple Sclerosis, Parkinson’s and Alzheimer’s disease are the most common neurodegenerative disorders. Unfortunately, no effective treatments are currently available to halt the progression of these neuroinflammatory diseases [1].
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Understanding disease suppressive soils
Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.
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Health and disease
Bone research provides plenty of detailed data about the health of a person or a group. This data is not only used to reconstruct the past but also to fight disease today.
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Respiratory health and disease in the Netherlands
Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).
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Polyfluorinated bis-styrylbenzenes as amyloid-beta plaque binding ligands
Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.
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functional brain connectivity: pharmacological modulation, aging and Alzheimer's disease
PhD defence
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Flower bulbs to treat Alzheimer's
The substance galanthamine from flower bulbs can fight symptoms of Alzheimer's disease. Nadeem Akram investigated how daffodils can optimally produce this natural remedy. PhD defence on 24 June.
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Plant ageing, rejuvenation and life history strategy
What are key regulators of plant ageing that can reverse ageing in plants (rejuvenation), and how can we use this knowledge to improve crop plants?
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Development & Disease in Animal Sciences
Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.
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Systems dermatology of inflammatory diseases
Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…
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Elizabeth (Liesbeth) de Lange
Science
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SysMedPD: Systems Medicine of Mitochondrial Parkinson's Disease
The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…
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Development & Disease in Microbial Sciences
Microbial Sciences'contribution to the Development & Disease research theme is to perform world-class research to understand cellular morphogenesis, growth, development and virulence of microbes.
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glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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Healthy ageing
The elderly accept may minor discomforts like stiffer muscles and getting tired more quickly, but they do want to go to their children's birthdays independently. Preventive elderly care helps people with that. The goal is to let people grow old while maintaining their self-reliance and independence…
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IBL Spotlight - Development and Disease
Lecture
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Development & Disease in Plant Sciences
Plant Sciences' contribution to the Development & Disease research theme is to unravel the processes that allow plants to adapt to changing abiotic and biotic environmental conditions or stresses, with the aim to contribute to the sustainable production of food, flowers and bio-based products using…
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Why arteriosclerosis looks like an autoimmune disease
Arteriosclerosis bears great similarities to autoimmune diseases. Researchers from Leiden University show this in a new study they published in the renowned scientific journal Nature Cardiovascular Research. 'This discovery suggests that treatment methods for autoimmune diseases might also be effective…
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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How an Alzheimer related protein forms plaques
Neurological diseases, such as Alzheimer's disease, are characterised by aggregates of protein in the brain. The connection of these aggregates to the disease itself is unclear. Martina Huber, Enrico Zurlo and colleagues published a new method to monitor the formation of these aggregates.
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Vitality and Ageing (Fulltime)
Are you thinking about studying Vitality and Ageing? Learn more and watch the video of our live-presentation we held at the Online Master's Open day.
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Vitality and Ageing (parttime)
Are you thinking about studying Vitality and Ageing, and are interested in our part-time programme? Learn more and watch our video of our live-presentation we held at the Online Master's Open day.
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Weathering the Ice Age
Where did species survive the cold cycles of the current Ice Age?
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Systems pharmacology of human neuroendocrine disease entities
An important hormone excreting gland in the human body is the pituitary
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metabolism: fundamental studies and clinical applications for Gaucher disease
How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?
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Impaired barrier of inflammatory skin diseases
Focus in skin research