PhD at Leiden University and Bruker - the Netherlands

What are the functions of the endocannabinoid system?

Associate professor at the Natural Products Laboratory, Institute of Biology, Leiden University - the Netherlands

The Biomedical Microscale Analytics group is led by Dr. Rawi Ramautar. In present-day metabolomics, and bioanalysis in general, the analytical toolbox used encounters difficulties for the analysis of limited amounts of biological samples. As a result, a significant number of crucial biomedical/clinical…

A staggering 6.5 billion chicks are killed worldwide every year. These are generally male chicks that are of no economic value. In Ovo has developed technology that can quickly determine the sex of a chick, to ensure that only female chicks are hatched. The first 150,000 chicks have now hatched in this…

The Dutch biotech start-up In Ovo is the first company to develop a large-scale solution for determining the sex of a chick while it is still in the egg. This fast and cheap technique can be applied mechanically at hatcheries, which was not possible before.

PhD Defence

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

A Dutch-led team of astronomers has discovered that high-mass stars are formed differently from their smaller siblings. Whereas small stars are often surrounded by an orderly disk of dust and matter, the supply of matter to large stars is a chaotic mess. The researchers used the Atacama Large Millimeter/submillimeter…

Simone van der Hof joined the Supervisory Board of the Foundation for Mass Claims and Consumers in connection with the Foundation's claim against TikTok.

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…

The current resurgence of whooping cough is alarming, and improved pertussis vaccines are thought to offer a solution. Outer membrane vesicle vaccines (omvPV) are potential vaccine candidates, but omvPV-induced humoral responses have not yet been characterized in detail.

TRANSVAC is a collaborative infrastructure project funded by the European Commission (EC), initially under the 7th Framework Programme (FP7) and currently under Horizon 2020. The project is a joint effort of leading European groups working in the field of vaccine development, and is coordinated by…

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

The Leiden Institute of Chemistry actively participates in several national research schools for MSc and PhD students. These schools are consortia that stimulate collaboration between research groups of the different participating Dutch universities. The research schools also offer advanced training…

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

In the controlled, censored, and taboo-ridden media landscape of communist China, one would not expect seeing a television show featuring real people having actual conflicts. Yet reality programmes about conflict mediation are mushrooming in the People’s Republic. Both the public and the authorities…

Pharmacologist Walter Boiten developed a new method to determine the amount of lipids in a person's skin. With this method he tested the effects of a new cream he developed for eczema patients. The first results are promising. Boiten defends his dissertation on 15 January.

The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).

FGGA students Amber Klompmaker (Master in Public Administration) and Imogen Liu (Research Master in Political Science and Public Administration) have been selected to participate in the Political Economy of Capitalism workshop of the Young Scholars Initiative of the Institute of New Economic Thinking…

EUniWell –the European University for Well-Being in which Leiden University and six other universities collaborate – is among the consortia selected for funding in the ‘European Universities Initiative’. The alliance will receive funding of 5 million euros from the European Commission.

In the podcast EU Scream, a non-for-profit organization based in Brussels, Martijn Nouwen tells about his research into communications about European tax rulings.

How do you ensure that a drug has an effect on the right protein – and nothing else? Chemist Anthe Janssen explored various methods for determining the selectivity of potential medicines. He also looked at the substance BIA 10-2474, after a man died in a French clinical trial in 2016. PhD defence on…

Source: Br. J. Pharmacol., Volume 172, Issue 3, pp. 940-55 (2015)

Science, Leiden Institute of Chemistry (LIC)

Vaccines are an extraordinary category of biopharmaceuticals. They are usually prophylactic and come in many types, from whole bacteria to peptides and nucleic acids. They are very cost effective and almost every human on the planet is vaccinated. The latter mandates that vaccines have to be extremely…

Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…

A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…

Papers written on the occasion of the 30th anniversary of the institute of Prehistory, Volume II.

The System Biomedicine and Pharmacology specialisation consists of compulsory and optional components.

Which metabolites of sponge are influenced by individual environmental or biological factors?

Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?

How do nanoparticles bioaccumulate and biodistribute in organisms?

On 14 and 15 March, students can register as candidates for a place in the University Council (UR) or one of the faculty councils. But what do these participation bodies do? UR member Femke van der Meulen takes us through the agenda for the next meeting.

February 2019 will see the launch of the Young Academy Leiden (YAL). Founded by the Leiden members of De Jonge Akademie of the Royal Dutch Academy of Arts and Sciences, the YAL has been designed to support the university’s talented early career scholars.

Source: ChemMedChem (2015)

Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

The OHBM Program Committee selected LUCL's Olga Kepinska to receive a Merit Abstract Award for the 2016 OHBM Annual Meeting in Geneva, Switzerland.

Supervisor: Xue Yang

PhD Defence

Leiden University has selected an architect for the realisation of its new beta-campus. As a team, Designers bureau Inbo in Rotterdam and JHK Architects have won the tender for phase 1, the new housing estate for the Faculty of Science.

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Livia, aged 7, was in class four. She loved to chat and was good at reading aloud. At least, at home. At school she never read aloud and she hadn't spoken a single word. What was going on? Selective mutism was the subject of the inaugural lecture by Maretha de Jonge, Professor by Special Appointment…

This project, under the supervision of Prof. Dr. Hans van der Plicht, comprises several studies aimed at the use of isotopes occurring naturally in organic material as tracers for both the climate change and its cultural impact at about 6200 BC. The research will be carried out by the co-applicant at…