The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

Science, Institute of Biology Leiden (IBL)

Ramautar

Promotor: Prof.dr. T. Hankemeier, Co-promotor: T.H. Reijmers

Science, Leiden Institute of Chemistry (LIC)

Promotor: Prof.dr. T. Hankemeier, Co-Promotor: R.J. Vreeken

Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

Designing and synthesizing high-affinity ligands for a given drug target have always been among the more important challenges in the drug discovery process.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Dr. Theo Reijmers

Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.

Development of micro-scale analytical tools to be used to address relevant biomedical questions in the field of neuroscience, and other application areas intrinsically dealing with small sample amounts.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

In this thesis integral points on affine del Pezzo surfaces are studied.

In the field of metabolomics, capillary electrophoresis-mass spectrometry (CE-MS) has become a very useful analytical technique for the profiling of highly polar and charged metabolites in biological samples. In order to highlight the unique features of CE-MS for metabolomics studies, Dr. Rawi Ramautar…

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

In recent years, the issue of mass tort litigation and the fair and efficient settlement and adjudication of mass torts has drawn increasing attention in academic discourse, legal practice and policy debates.

Target selectivity is an important aspect of any drug molecule, and certainly a parameter to be optimized. That is not trivial for a number of reasons. First of all hundreds of drug targets (receptors, enzymes, ion channels) exist, and no single lab in the world has assays for all of them.

How did parties as political organizations emerge?

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…

My work focuses on a class of astronomical objects called protoplanetary disks.

The BioMedical Metabolomics Facility Leiden (BMFL) offers a highly structured environment for advanced metabolomics studies. BMFL builds on fully validated, state-of-the-art platforms that each cover a part of the human metabolism and together span the complete human metabolome.

Promotor: A.P. IJzerman

Promotor: A.P. IJzerman

Structure-affinity relationship (SAR) and structure-kinetics relationship (SKR) studies were combined to investigate a series of biphenyl anthranilic acid agonists for the HCA2 receptor.

Promotor: Prof.dr. E.F. van Dishoeck, Co-promotor: S. Bruderer

Source: J Med Chem (2015)

Animal models suggest that the chemokine ligand 2/CC-chemokine receptor 2 (CCL2/CCR2) axis plays an important role in the development of inflammatory diseases. However, CCR2 antagonists have failed in clinical trials because of a lack of efficacy.

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: Dr. H.Hoekstra

Promotor: Prof.dr. T. Hankemeier, Co-promotor: R.J. Vreeken

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

Source: Eur J Med Chem (2015)

The analysis of protein residues extracted from the storage containers of circa 50,000 year old bone-tools reveals Neandertal strategic selection of bovid ribs to make some of their “lissoirs”.

As LUC The Hague only has 200 places available for first year students, we select students based on multiple factors in order to assess best fit.

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

The Bachelor programme Psychology will admit a limited number of students (Numerus Fixus). A selection process will determine which applicants best fit our programme. Also, it is a good way for you to discover if Psychology in Leiden is the programme for you.

SMR can be used to measure the mass of adsorbed protein to nanoparticles with a high precision in the presence of free protein.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Our selection and placement procedure starts with your application (i.e. prior to 15 January of the calendar year in which you intend to start) and ends with—hopefully—an invitation to you to enrol as an IRO student. This page tells you all you need to know about the steps to be taken in between.

Did we spark your interest in the Leadership Programme (LLP) and are you looking forward to take on this challenge in the coming academic year? Apply now! The LLP starts once every year, on the 7th of November, and ends in June.

Leiden University has participated in an international study carried out by the CARMENES consortium, which has discovered two small, terrestrial planets around Teegarden’s Star. The planets have masses similar to Earth and their temperatures could be mild enough to sustain liquid water on their surf…

The Young Academy Leiden is looking for new members. In this round, candidates are nominated by the Faculty Boards and the Executive Board of LUMC.

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…