What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

Pathways of toxicity

Adverse drug reactions (ADRs) remain one of the major reasons for patient mortality and (early) drug withdrawal. Currently, different in vivo and in vitro models are used to assess the toxic potential of drugs in the pre-clinical phase. Unfortunately, the predictive value of this model does not fit…

Analysis of drug adversity

High throughput microscopy

Up to 50% of all children and adolescents growing up worldwide are exposed to at least one form of childhood adversity (CA), which is one of the strongest predictors for later-life psychopathology.

To what extent are university teachers' individual learning paths influenced by their teaching experience, motivation, and conceptions of teaching and learning through educational technology?

This thesis proposes multiple paths towards the development of a performance practice in Computer Music.

Tactile Paths is an artistic research project that aims to expand and articulate the feedback between notation and improvisation in experimental music.

PhD defence

The current dissertation presents a review study and three empirical studies, focusing on the understanding of the state of the art of research about PjBL in higher education and the investigation of the relation between PjBL and student outcomes in the context of Chinese higher education.

The path to rational drug and dose selection

How did slaves in the eighteenth century manage to empower themselves and their kin, and why did this become all the more difficult in the nineteenth century?

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

On 15 February 2022, Morshed Mannan defended the thesis 'The Emergence of Democratic Firms in the Platform Economy: Drivers, Obstacles, and the Path Ahead'. The doctoral research was supervised by Prof. I.S. Wuisman and Prof. J.A.A. Adriaanse.

In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.

In this article, Samuels focuses on the active fostering of subjunctivity in processes of narrative worldmaking. Drawing extensively from the narrative of an HIV‐positive woman in Indonesia, she shows that by subjunctively leaving open multiple narrative trajectories and future possibilities, individuals…

This article examines the position of victims and those affected within communication theory. Current research has broadly been skewed toward reputation management and protecting brand value as primary goals of crisis communication efforts. The authors offer recommendations for crisis communication…

This thesis investigates Søren Kierkegaard’s place in Martin Heidegger’s first Freiburg period lecture courses.

Promotor: Prof.dr. E.F. van Dishoeck, Prof.dr. F.F.S. van der Tak (RUG)

Despite the value of technology integration for educational equity and quality being emphasized by numerous studies, many gaps exist about how technology integration can be approached in policy plans, implemented in pedagogical practices, and embraced by teachers, students, and parents.

PhD defence

Why do certain incidents of serious violence end lethally whereas others do not? What role do personal characteristics of offenders and victims play and how do immediate situational factors influence outcomes?

Anne-Laura van Harmelen, professor Brain, Safety and Resilience will give her inaugural lecture ‘Resilience does not exist’ (in Dutch) on Monday 27 June. In her inaugural lecture she will discuss resilience after childhood adversity.

On December 12th & 13th composer and doublebass-player Christopher Williams will defend his thesis Tactile Paths to obtain his doctoral degree.

Our research in the area of safety sciences aims to increase the mechanistic understanding of cellular toxicity of drugs and, in a broader sense, chemicals.

How did interests outside the scope of the Dutch chartered trading companies influence the career-paths of Dutch colonial governors?

The 2012 crisis in Mali, where the state collapsed and terrorist groups took over the north, came as a surprise to many. Mali had been considered a poster-child for democracy and was judged as considerably more stable than its neighbors by leading quantitative indices of state fragility. This article…

Patients share valuable advice and experiences with their peers in online patient discussion groups.

PhD defence

Ecotox is a stimulating top-facility that provides an integrative research environment around the topic of ecotoxicological testing and experimental research. Research focus: Dose-response modelling Mode-of-actions and mechanism-of-actions Test method development, in view of targets in…

The Office for International Education held its second annual Career Café on the evening of 6 February.

The judge as a problem-solver in domestic violence cases involving child victims.

What are the risks of nanoparticles?

Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

Promotor: R. Tijdeman, Co-promotor: C. Kraaikamp

Nicoleta Paraschivescu highlights the pedagogical and artistic aspects of partimenti in her book 'Giovanni Paisiellos Partimenti: Paths to a practical understanding', released today.

PhD defence

On International Women's Day (8 March) we take time to consider female emancipation and participation. What does this day mean for Leiden University, and how does it tie in with our aim of becoming more diverse and inclusive? We talked about these issues with Annetje Ottow, who recently became the…

On 20 January 2022, Marco Stam defended the thesis 'Essays on Welfare Benefits, Employment, and Crime'. The doctoral research was supervised by Prof. M.G. Knoef.

The Research Group 'Violence and Violence Prevention' studies interpersonal violence. We seek to better understand the dynamics underlying interpersonal conflict.

We are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

On April 4 a new composition and a new instrument by researcher Aart Strootman will see the light of day at the 55th edition of Spring Festival 2022, presented by the Royal Conservatoire’s Composition department.

Developmental considerations in the design and delivery of cognitive-behavioural therapy for adolescent school refusal

Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…