2,056 search results for “adverse outcome path” in the Public website
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Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
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Mitochondria in chemical-induced toxicity
Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…
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Mathematical modelling of adverse outcome pathways
In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.
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Integrated omics approaches for systems understanding of adverse outcome pathways
Pathways of toxicity
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Molecular mechanisms of adverse outcome and translational biomarkers
Adverse drug reactions (ADRs) remain one of the major reasons for patient mortality and (early) drug withdrawal. Currently, different in vivo and in vitro models are used to assess the toxic potential of drugs in the pre-clinical phase. Unfortunately, the predictive value of this model does not fit…
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human IPSC-derived reporter systems for image-based analysis of drug adversity
Analysis of drug adversity
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microscopy for cellular adaptive stress response pathways in drug adversity
High throughput microscopy
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reducing brain responses to stress in adolescents exposed to childhood adversity: a pre-registered systematic review
Up to 50% of all children and adolescents growing up worldwide are exposed to at least one form of childhood adversity (CA), which is one of the strongest predictors for later-life psychopathology.
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University teachers’ learning paths during technological innovation of education
To what extent are university teachers' individual learning paths influenced by their teaching experience, motivation, and conceptions of teaching and learning through educational technology?
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Multiple Paths. Towards a Performance Practice in Computer Music
This thesis proposes multiple paths towards the development of a performance practice in Computer Music.
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Tactile Paths: on and through notation for improvisers
Tactile Paths is an artistic research project that aims to expand and articulate the feedback between notation and improvisation in experimental music.
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Outcome measures in Duchenne muscular dystrophy
PhD defence
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Online project-based higher education: student collaboration and outcomes
The current dissertation presents a review study and three empirical studies, focusing on the understanding of the state of the art of research about PjBL in higher education and the investigation of the relation between PjBL and student outcomes in the context of Chinese higher education.
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Personalised pharmacotherapy in paediatric epilepsy : the path to rational drug and dose selection
The path to rational drug and dose selection
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Paths through slavery: urban slave agency and empowerment in Suriname, 1700-1863
How did slaves in the eighteenth century manage to empower themselves and their kin, and why did this become all the more difficult in the nineteenth century?
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Personalised medicine for multiple outcomes: methods and application
The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.
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Democratic Firms in the Platform Economy: Drivers, Obstacles, and the Path Ahead
On 15 February 2022, Morshed Mannan defended the thesis 'The Emergence of Democratic Firms in the Platform Economy: Drivers, Obstacles, and the Path Ahead'. The doctoral research was supervised by Prof. I.S. Wuisman and Prof. J.A.A. Adriaanse.
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Into the Darkness: Forging a Stable Path Through the Gravitational Landscape
In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.
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“This Path Is Full of Thorns”: Narrative, Subjunctivity, and HIV in Indonesia
In this article, Samuels focuses on the active fostering of subjunctivity in processes of narrative worldmaking. Drawing extensively from the narrative of an HIV‐positive woman in Indonesia, she shows that by subjunctively leaving open multiple narrative trajectories and future possibilities, individuals…
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the Intersection of Psychosocial, Ethical, and Crisis Communication Paths
This article examines the position of victims and those affected within communication theory. Current research has broadly been skewed toward reputation management and protecting brand value as primary goals of crisis communication efforts. The authors offer recommendations for crisis communication…
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Paths Towards Philosophy, Søren Kierkegaard's place in Martin Heidegger's first Freiburg period lecture courses (1919-1923)
This thesis investigates Søren Kierkegaard’s place in Martin Heidegger’s first Freiburg period lecture courses.
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Paving the path between low- and high-mass star formation: dynamics probed by Herschel far-infrared spectroscopy
Promotor: Prof.dr. E.F. van Dishoeck, Prof.dr. F.F.S. van der Tak (RUG)
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integration in education: policy plans, teacher practices, and student outcomes
Despite the value of technology integration for educational equity and quality being emphasized by numerous studies, many gaps exist about how technology integration can be approached in policy plans, implemented in pedagogical practices, and embraced by teachers, students, and parents.
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Comprehensive measurement of long-term outcomes and costs of rehabilitation in patients with stroke
PhD defence
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personal characteristics and immediate situational factors in the outcome of serious violence
Why do certain incidents of serious violence end lethally whereas others do not? What role do personal characteristics of offenders and victims play and how do immediate situational factors influence outcomes?
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Facts and myths about resilience after childhood adversity
Anne-Laura van Harmelen, professor Brain, Safety and Resilience will give her inaugural lecture ‘Resilience does not exist’ (in Dutch) on Monday 27 June. In her inaugural lecture she will discuss resilience after childhood adversity.
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Public Defense: Tactile Paths
On December 12th & 13th composer and doublebass-player Christopher Williams will defend his thesis Tactile Paths to obtain his doctoral degree.
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Drug safety Sciences
Our research in the area of safety sciences aims to increase the mechanistic understanding of cellular toxicity of drugs and, in a broader sense, chemicals.
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Serving the East and the West – Strategies in Imperial Career Paths Within the VOC and the WIC
How did interests outside the scope of the Dutch chartered trading companies influence the career-paths of Dutch colonial governors?
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The Unforeseen 2012 Crisis in Mali: The Diverging Outcomes of Risk and Threat Analyses
The 2012 crisis in Mali, where the state collapsed and terrorist groups took over the north, came as a surprise to many. Mali had been considered a poster-child for democracy and was judged as considerably more stable than its neighbors by leading quantitative indices of state fragility. This article…
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Knowledge discovery from patient forums: gaining novel medical insights from patient experiences
Patients share valuable advice and experiences with their peers in online patient discussion groups.
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Healthcare improvement based on learning from adverse outcomes
PhD defence
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Maximilian Scheuplein
Faculteit der Sociale Wetenschappen
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Coen van Hasselt
Science
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Ecotox
Ecotox is a stimulating top-facility that provides an integrative research environment around the topic of ecotoxicological testing and experimental research. Research focus: Dose-response modelling Mode-of-actions and mechanism-of-actions Test method development, in view of targets in…
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'We are the managers of our own professional path'
The Office for International Education held its second annual Career Café on the evening of 6 February.
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Child victims and domestic violence
The judge as a problem-solver in domestic violence cases involving child victims.
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The added risk of size
What are the risks of nanoparticles?
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Computational Biology
Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.
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Induced substitutions
Promotor: R. Tijdeman, Co-promotor: C. Kraaikamp
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Edwin de Beurs
Faculteit der Sociale Wetenschappen
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Book publication: Giovanni Paisiellos Partimenti: Paths to a practical understanding
Nicoleta Paraschivescu highlights the pedagogical and artistic aspects of partimenti in her book 'Giovanni Paisiellos Partimenti: Paths to a practical understanding', released today.
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Prediction of adverse health outcomes in older patients visiting the Emergency Department: the APOP study
PhD defence
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‘Sometimes choosing a different path can take you further’
On International Women's Day (8 March) we take time to consider female emancipation and participation. What does this day mean for Leiden University, and how does it tie in with our aim of becoming more diverse and inclusive? We talked about these issues with Annetje Ottow, who recently became the…
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Essays on Welfare Benefits, Employment, and Crime
On 20 January 2022, Marco Stam defended the thesis 'Essays on Welfare Benefits, Employment, and Crime'. The doctoral research was supervised by Prof. M.G. Knoef.
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Violence and Violence Prevention
The Research Group 'Violence and Violence Prevention' studies interpersonal violence. We seek to better understand the dynamics underlying interpersonal conflict.
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Division of Drug Discovery & Safety
We are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.
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Aart Strootman’s research outcome premieres at Spring Festival 2022
On April 4 a new composition and a new instrument by researcher Aart Strootman will see the light of day at the 55th edition of Spring Festival 2022, presented by the Royal Conservatoire’s Composition department.
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The @school project
Developmental considerations in the design and delivery of cognitive-behavioural therapy for adolescent school refusal
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Mathematical modeling of cellular stress pathways for mechanistic understanding of chemical-induced liver injury
Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…