Microneedles represent promising tools for delivery of drugs to the skin. However, before these microneedles can be used in clinical practice, it is essential to understand the process of skin penetration by these microneedles.

The 9th Network Europe Conference in Edinburgh was held at June 2017 in Edinburgh and organized by the Europa Institut Zurich. The contributions of the conference are now published.

How do humans control their thoughts and actions, and what can high-field brain scanning reveal about the underlying processes?

On May 30th, Yang Yang succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Yang on this great result.

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

On November 1st, Min Liu succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Min on this great result.

This dissertation aims to establish a dialogue between ethnomusicology (more specifically indigenous organology), the anthropology of art and the culture of the Apinaye peoples, in order to understand how the musical objects of these peoples are learned and taught, and thus to understand its musical…

This report investigates the different approaches in the authorization process of GMOs for commercial use in the European Union and the United States of America. Three main aspects are considered and analyzed as potential causes of differences in the authorization process of GMOs for commercial use.…

To what end and how does Plautus constantly underline the Helleni(sti)c provenance of his art? How does this aspect relate the author’s originality?

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

This article on private active cyber defense by Dennis Broeders is part of a special issue of the Journal of Cybersecurity, based on a selection of contributions taken from the 2019 Conference on Cyber Norms organized by The Hague Program for Cyber Norms.

Handbook of Signal Processing Systems is organized in four parts. The first part motivates representative applications that drive and apply state-of-the art methods for design and implementation of signal processing systems; the second part discusses architectures for implementing these applications;…

How do parliamentarians secure their political future? Are their activities in the legislature connected to their place on the candidate list from one election to the next? Political scientists Tom Louwerse and Cynthia van Vonno examine the Dutch case. Their main finding is that speaking in the plenary…

Do general practitioners recognize children with or at risk of problematic anxiety and is there a pattern that might help differentiate those with and without anxiety disorders in general practice?

Active-site directed probes are powerful in studies of enzymatic function. We report an active-site directed probe based on a warhead so far considered unreactive.

In this article in International Affairs, Saskia Postema and Jan Melissen examine Chinese celebrities' UN-affiliated Weibo activism in the context of China's increasing engagement in the United Nations, which coincides with a shrinking domestic public sphere under Xi Jinping's leadership.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

How was anti-communism organized in the West? New volume edited by Giles Scott-Smith, Luc van Dongen and Stephanie Roulin on the aims, arguments and associations of a range of transnational anti-communist activists during the Cold War.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Three at the same time: a ligation strategy combining tetrazine–norbornene cycloaddition, Staudinger–Bertozzi ligation, and copper(I)-catalyzed click reaction was used to label the three catalytic activities of the proteasome simultaneously in a single experiment. The orthogonality of the three ligation…

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…

How do European Muslim men and women become involved in a violent jihadist struggle abroad?

Promotores: G.W. Canters, T.J. Aartsma

Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)

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Can we tailor catalysts at the atomic scale by means of high-school chemistry and geometry rules?

Mr. S. Al Daghistani defended his thesis on 30 November 2017

The aim of this study was to provide insight into how teachers in higher education can be supported in the design, implementation and evaluation of group assignments by developing a theoretical and evidence-based framework for the design of group assignments.

Quantifying physical activity (using accelerometers) and combining the frequency and intensity of activities with health data (brain MRI, traditional clinical parameters and metabolomics) is of utmost importance to monitor mobility and health among older individuals and study health promotion during…

The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.

Do you want to know more about Cultural Anthropology and Development Sociology and what it is like to study in Leiden? Come to our online or on campus information events.

The probability for dissociation of molecules on metal surfaces, which often controls the rate of industrially important catalytic processes, can depend strongly on how energy is partitioned in the incident molecule. There are many example systems where the addition of vibrational energy promotes reaction…

Source: Mol Psychiatry (2015)

A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian β-glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non-mammalian β-glucosidases (see picture). These probes offer new ways to study β-exoglucosidases, and configurational…

The drug BIA 10-2474 inhibits fatty acid amide hydrolase (FAAH), a lipase that degrades a specific endocannabinoid. On the basis of this activity, BIA 10-2474 was being developed as a potential treatment for anxiety and pain. In a phase 1 trial of the drug, one subject died, and four others suffered…

Promotor: A.P. IJzerman

In this dissertation the author digs into the constituent elements of River Plate tango in order to decode how specific musical materials were organized and combined by four outstanding musicians: Pugliese, Salgán, Piazzolla and Beytelmann.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

On 5 September 2019, Jennifer Doekhie defended her thesis 'Dimensions of desistance: A qualitative longitudinal analysis of different dimensions of the desistance process among long-term prisoners in the Netherlands'. The doctoral research was supervised by Prof. P. Nieuwbeerta.

On 3 December 2019, Hanna Bosdriesz defended her thesis 'Furthering the fight against impunity in Latin America: the contributions of the Inter-American Court of Human Rights to domestic accountability processes'. The doctoral research was supervised by Prof. L.J. van den Herik and Prof. M.A.H. van…

Why are highly skilled migrants not perceived as migrants in scholarly, policy, and public debates, and to what extent is their settlement process different?

How to reconstruct the middle parts (videlicet haute-contres, tailles and quintes) from French orchestral pieces, which survived only in their reduced forms (featuring primarely dessus and continuo), according to historical examples?

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…