Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Here you will find an overview of the Spaces for Active Teaching and Learning already implemented at Leiden University and LUMC. These rooms vary in size, location, material affordances, and technological affordances, and thus vary in the forms of pedagogy they best support. You can use this site as…

2 joint initiatives began in 2019 which attempt to connect the various efforts around active learning at Leiden University: the active learning network, and the Saltswat project.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

You can get various forms of support for you active learning ambitions. Have you already reflected on your teaching practice and have a clear idea of your goals? Your first point of contact should then be your ICTO Coordinator & ICLON. Do you want to join the network of others involved in the topic?…

How does task context affect children’s word productions?

This book provides a comparative analysis of the process of breach across ten different European jurisdictions by identifying and elaborating a number of key analytical themes through which the different systems can be compared and evaluated.

Heightened activation of the striatum that adolescents show in response to reward is often associated with risk-taking and negative health consequences. This article in Nature Communications investigates a potential positive side of this heightened activation. It shows that the activity peak in late…

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

While bioinformatics methods deal with the analysis of sequence information (be it proteins or DNA), the field of cheminformatics is concerned with the analysis of small-molecule datasets.

Promotor: Prof.dr. B.R. Katzy, Co-promotor: R. Ortt

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Are you interested in one of our vacancies? To get to know each other well, we follow a number of steps in the application process.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

In this project, we plan to combine two strands of research in speech processing: (a) the impact of prosody on speech processing and (b) the impact of musical training on speech processing. In our project we will test 8 year-old children with different degrees of musical training: (a) primary school…

What holds people together and what makes them willing to fit within larger political structures? Our project examines this question in the practices of dynastic rulership in Eurasia ca. 1300-1800.

How the global distribution of vegetation stands dominated by arbuscular and ectomycorrhizal plants relate to principle aspects of belowground carbon accumulation processes?

This thesis investigates the processing of words written in Japanese kanji and Chinese hànzì, i.e. logographic scripts.

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

In his groundbreaking Imagined Communities, first published in 1983, Benedict Anderson argued that members of a community experience a

How can teachers be motivated by their students’ data in making stepwise changes to their teaching practices?

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…

This book examines how renewed forms of artistic activism were developed in the wake of the neoliberal repression since the 1980s.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

The blended flipped classroom is a partially online, partially offline course to teach social science research methods. Online, students watch video lectures, do readings, and complete short exercises to acquire basic knowledge of research methodologies and academic skills.

Our Master’s Vitality and Ageing can be your way to change the future! It gives you a fresh view on your personal future, and more in particular, on that of the future of elderly care. On this page you will find all the information you need to make your choice. One click is all it takes.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

On April 4th, Zohreh Shiamizadeh succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Zohreh on this great result.

In this dissertation, electrophysiological (EEG) and behavioural measures are used to investigate how allophonic tonal variants and sub-phonemic features are processed during Mandarin and Dutch speech production, visual processing of written words and reading aloud.

Activity-based protein profiling (ABPP, also termed chemical proteomics), is one of the pillars of chemical biology, and at LED3 we have taken it to the next level. ABPP allows the assessment of protein function in live cells and tissues, which means that the activity of a complete protein family can…

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

The close interaction between organic chemi stry and biology goes back to the late 18th century, when the modern natural sciences began to take shape. After synthetic organic chemistry arose as a discipline, organic chemists almost immediately began to pursue the synthesis of naturally occurring compounds,…

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Can process-oriented dynamic testing be applied to everyday educational practice?

This project aims to investigate the underlying (neurocognitive) linguistic processes of ellipsis resolution, particularly gapping.

Koper

Assessment of teaching is currently becoming more and more common practice. As such assessment is generally based on complex, qualitative data from multiple sources (e.g., lesson plans, video-taped lessons, written reflections of the teacher on his or her performance), the overall quality of the assessment…

In this study, we evaluated the influence of supercritical carbon dioxide (scCO2) spray drying conditions, in the absence of organic solvent, on the ability to produce dry protein/trehalose formulations at 1:10 and 1:4 (w/w) ratios.

Making the Virtuagym e-platform suitable for wheelchair users with a spinal cord injury or lower limb amputation.

Promotores: Prof. Dr. Th.J.C. van Berkel, Prof. Dr. M. van Eck

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

The research question is that unconscious perseverative cognition (UPC) is responsible for a considerable part of cardiovascular (CV) activity that occurs even in the absence of threats and other stressors that one may encounter in one’s daily life.