The central question of this thesis is: What drives late Middle Paleolithic stone artifact variability? In its attempt to answer this question, this thesis is a contribution to understanding variability within and between late Middle Paleolithic assemblages of the European Plain.

Promotor: T. Schmidt

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Promotor: B. van de Water

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Promotores: G.W. Canters, T.J. Aartsma

This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.

This thesis describes the design, characterization and application of dextran based crosslinked network.

Promotor: Prof.dr. E. F. van Dishoeck, Co-promotor: A. N. Heays

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

LUCDH facilitates workshops that promote the acquisition of skills and knowledge in employing digital tools.

Science, Leiden Academic Centre for Drug Research (LACDR)

Promotor: H.J.M. de Groot

NL-BioImaging AM is a distributed research infrastructure aimed at promoting progress in the most cutting edge microscopy technologies and providing open access to these technologies to a broad community of academic and industrial users. All Netherlands bio(medical) microscopy centers participate.

Update : March 2020 Director: Professor Dr Harco Willems (KU Leuven), co-director Dr Marleen De Meyer (KU Leuven & NVIC)

A linguistic reconstruction of the migration of the Tocharians from Europe to China

Our call for workshop proposals was met enthousiastically by various people, and we are happy to announce that the following four workshops were unanimously selected by the organising committee.

The Impact of Mobility and Migration in the Roman Empire assembles a series of papers on key themes in the study of Roman mobility and migration.

This dissertation deals with Hegel’s theory of the sublime (das Erhabene). I focus specifically on die heilige Poesie (sacred poetry), a form of art that he identifies with the Judaic Psalms and which I claim to be the core of Hegel’s approach to sublimity. I claim that Hegel’s apparent lack of interest…

Chenyu Cheng defended her thesis on 6 April 2017.

Stephen Moore defended his thesis on 26 May 2020.

At LUCL, researchers aim to understand, describe, and preserve the linguistic diversity of the indigenous Americas.

At LUCL, researchers aim to contribute to a comprehensive and informed perspective on the human past.

Research at the Leiden University Centre for Linguistics (LUCL) focuses on linguistic variation and diversity. In order to create more awareness and scientific understanding of this topic, research activities are clustered around six (overlapping) umbrella programmes. Many of our researchers are active…

This dissertation provides a thorough review of the words belonging to the oldest layer of Germanic loanwords in Proto-Slavic and answers the question of how these words were adapted to the Proto-Slavic accentual system.

The Flentrop Organ is the third organ to have been built for the Great Auditorium in the Academy Building in Leiden.

This project, South American population history revisited: multidisciplinary perspectives on the Upper Amazon (SAPPHIRE), investigates population dynamics in western South America on the basis of traces in the geographical, genetic, archaeological, ethnological, and linguistic record.

Leiden Institute of Advanced Computer Science (LIACS)

Humanities, Centre for Linguistics

Bioprinters that enable scientists to engineer complex tissues and organs. It sounds like science-fiction, but not for the scientists of the Alireza Mashaghi lab at the Leiden Academic Centre for Drug Research. The lab has recently been equipped with two state-of-the-art bioprinters: BioX and LumenX+.…

Lecture

Lecture

In order to optimize treatment, it is necessary to closely monitor and manage the patient’s health status by means of ‘precision diagnostics and targeted therapy’. The specialisation combines the techniques and applications of these sensing (monitoring) and stimulation techniques. The field of sensing…

The team consists of

In the video series LUCAS Explains, young researchers tell about current societal and cultural topics from a historical or fresh point of view. The subjects range from diversity to national identity and from inclusiveness to migration. The videos stretch the history from the Classics to the present…

In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.

The Laboratory for Human Osteoarchaeology specialises in the macroscopic and microscopic analysis of human remains. We use cutting edge scientific approaches to address archaeological, historical, and anthropological research questions. In addition to paleopathological, histological, and 3D scanning…

Key publications of the Cancer Drug Target Discovery group

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

How do we experience sensual wonder and enchantment and to what extent can (early) modern imagination-techniques be implemented to create an artwork and performance, which offer a sensory and novel experience.

The Centre for Digital Heritage undertakes collaborative international research in the field of Digital Heritage. It is an initiative of the University of York.

Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

How do humans construct their self?

PhD defence