Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

The imaging group focuses on bio-imaging, image analysis and visualization.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Joost Batenburg is a mathematician and computer scientist who works to build bridges to other disciplines. He hopes to bring intelligent software to fields where it can make a difference. Conversely, he also seeks connections to the disciplines that are needed to make AI a success.

Promotor: K.J. Batenburg

With tomography it is possible to reconstruct the interior of an object without destroying.

Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…

Living cells on topographically-controlled substrates: Understanding Cell Motility in a Quasi-3D Environment

In this thesis we present several methods to automate tomographic reconstruction algorithms and several novel tomographic reconstruction algorithms with the focus on being easily applicable and efficient to use.

A technique originally developed for satellite imaging can now be used to recover pictographic texts from underneath the surface of a five hundred year old Mexican manuscript.

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

An experimental approach to organic palaeolithic technology

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

This specialisation focuses on two important trends in health care: early diagnosis and developing the most targeted patient-specific treatment possible with the shortest possible recovery time and minimal side effects.

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

This dissertation presents a comprehensive description of Xinka, an indigenous language from southeastern Guatemala. The description is based on a missionary grammar that is titled Arte de la lengua szinca and was written by the priest Manuel Maldonado de Matos around 1773.

We live in a world of things and people in the past must have been as closely entangled with their material surroundings as we are now. In the Laboratory for Artefact Studies Van Gijn takes a close look at the biographies of objects: what kind of raw material an object is made off and what is its provenience,…

Dorothea Schulz & Martin Hense

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Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Promotor: Prof.dr. K.J. Batenburg

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

The chaotic years after the Civil War are often seen as a time of uniquely American idealism—a revolutionary attempt to rebuild the nation that paved the way for the civil rights movement of the twentieth century. But Adam Fairclough rejects this prevailing view, challenging prominent historians such…

This study aims to make a practical contribution to a new understanding and use of 3D reconstructions, namely as ‘laboratories’ to test hypotheses and visualize, evaluate and discuss alternative interpretations.

A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…

An assessment of Libyan legislation

Leiden University archaeologists are reconstructing houses from the Stone Age, using only resources available during that period. This method offers surprising insights into the ingenuity of our distant ancestors, and challenges existing archaeological views.

Another research line is the development of a spatial CNS drug distribution model, by ultimately including the 3-dimensional anatomical organization of the CNS.

Tomography is a powerful technique to non-destructively determine the interior structure of an object.Usually, a series of projection images (e.g.\ X-ray images) is acquired from a range of different positions.

Proceedings of the XVII UISPP World Congress (1–7 September, Burgos, Spain). Volume 7/Sessions A4b and A12

The rapid advances in imaging technology enable to see inside the body with ever increasing detail.

Agricultural foods naturally vary in their detailed internal structure. To facilitate early detection of health hazards due to contamination or disease, predict maturity and minimize wastage, it is critical to take into account the internal characteristics of each individual product, as these enable…

A computer can look at, and learn from, many more images than a human specialist. AI systems are rapidly becoming indispensable for medical and biological applications. But they still have to learn how to explain their decisions.

This page is under construction.

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

To study how planetary systems come into existence we study much younger systems still in formation.

Promotor: M.A.G.J. Orrit

This project intends to provide an integrated linguistic assessment of the hypothesised migration route of the Tocharians.

Promotores: S.J. Edixhoven, P.Parent

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

Anna Scott is a Canadian pianist-researcher interested in using the early twentieth century recordings of the Brahms circle of pianists to question persistent gaps between the loci of knowledge, ethics, and act in both modern mainstream and historically-informed performances of Brahms’s late piano w…

Obtaining imaging data is nowadays only the start of your project. Once the data has been acquired there are many things that still need to be done.

This page is under construction.

PLATO is a centre for research and development in education and training. 4 areas of expertise and 4 methods.

In this project we develop algorithms to automatically detect a particular type of archaeological sites in satellite images of the Alps.

Attitudes towards cultural heritage have long been characterised by an ‘endangerment sensibility’ concerned with preventing losses. Recently, however, critical heritage scholars have argued that loss can be generative, facilitating the formation of new values and attachments. Their arguments have focused…

What can languages spoken in the Lesser Sunda Islands today tell us about the histories of its various population groups?