We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.

The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

Promotor: A.P. IJzerman

This PhD thesis concerns the topic of arithmetic geometry. We address three different questions and each of the questions in some way is about counting how big some set is or can be.

Promotor: P. Stevenhagen, Co-promotor: R.M. van Luijk

Promotores: P. Stevenhagen, L. van Geemen (Università degli studi di Milano), Co-Supervisor: Ronald M. van Luijk

Promotor: Prof.dr. P. Hooykaas, Co-promotor: Dr. R. Offringa

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Promotor: Prof.dr. E.J.J. Groenen

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Promotor: M. Ubbink, Co-promotor: G. Siegal

To deliver a Virtual Sensor tool optimised to exploit the synergy between Sentinels 2 and 3 to allow the consistent retrieval of land surface parameters (Albedo, LAI, and LST); To extend the existing capabilities of land EO data assimilation tools to add capacity to handle data in the thermal domain…

Promotor: Prof.dr. C.A.M.J.J. van den Hondel, Dr. ir. V. Meyer, Co-promotor: Dr. A.F.J. Ram

Promotor: M. Ubbink, Co-promotor: G. Siegal

Oxidation is a common degradation pathway that affects therapeutic proteins and peptides during production, purification, formulation, transportation, storage and handling of solid and liquid preparations. In the present work we review the scientific literature about structural and biological consequences…

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

In our research protein translocation from Agrobacterium into yeast and plant cells is studied to obtain fundamental insights in the translocation process

Promotor: M. Ubbink, Co-promotor: G. Siegal

In this study, we evaluated the influence of supercritical carbon dioxide (scCO2) spray drying conditions, in the absence of organic solvent, on the ability to produce dry protein/trehalose formulations at 1:10 and 1:4 (w/w) ratios.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

In the overview below you can find the LUC Newsletters that were send out during block 3 and spring break in semester 2 of academic year 2019 - 2020.

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

How can we develop a new microscope that can distinguish individual atoms in proteins?

Promotor: Prof.dr. M. Ubbink

Promotor: W. Jiskoot, Co-promotor: H.A. Every

The Protein Centre can supply you with purified proteins that are essential for many experiments, ranging from in vitro inhibitor screening and enzymatic analysis to manipulation of life cells.

The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.

SMR can be used to measure the mass of adsorbed protein to nanoparticles with a high precision in the presence of free protein.

The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).

Promotor: A. Kros

For the first time ever, a float from Leiden University is taking part in the Grand Parade during the Relief of Leiden or Leidens Ontzet. October 3 is one big party in Leiden, and the University is joining in big style to celebrate its 444th anniversary.