Analysis of neuroimaging data requires multiple steps where statistics play a crucial role. The MRI methods research group develops new statistical methods that are accurate, transparent and easy to use.

Mapping the neural mechanisms underlying social motivations of adolescents and adults

Special amplifying agents can make MRI scanners and NMR techniques hundreds of times more sensitive. Leiden physicists have now found a method to test their efficiency. More sensitive MRI scans could for example improve our understanding of cystic fibrosis or Parkinson’s disease. Publication in PCCP…

This dissertation examines what network in the human brain is involved in the perception of prosody and whether activity within this network is modulated by the personality trait alexithymia.

By detecting the tiny forces between a micrometer sized magnet and the spins of hydrogen nuclei, we can do MRI with a volume resolution that is approximately 12 orders of magnitude better than a conventional MRI.  

Just imagine: you see someone being treated unfairly. Do you find it more rewarding to help the victim or punish the perpetrator? Research by Leiden psychologist Mirre Stallen indicates that punishing is more rewarding. Publication in JNeurosci.

There have been indications for decades that there is a link between increased iron levels in the brain and Alzheimer’s disease. Leiden physicists find this connection as well, thereby now making a distinction between different forms of iron. They identify specific iron forms that increase in Alzheimer’s…

With his ice-cold nano force sensor, Tjerk Oosterkamp searches for the boundary between the quantum world and the everyday world. The Leiden physicist has received an NWO subsidy of 600,000 euros.

Vocal learning is a trait shared by songbirds and humans. It is also a trait that is restricted by the brain rather than by a species' vocal apparatus. In this dissertation, functional MRI is employed in both species in order to explore potential common neural mechanisms underlying the ability to develop…

An MRI scanner is much more than a machine alone. It is an extremely versatile technique that provides numerous opportunities for finding out more about the workings of the human brain, says Thijs van Osch, Professor of Radiology, with a particular emphasis on experimental cerebrovascular imaging. Inaugural…

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

For many years, scientists have observed a correlation between Alzheimer’s disease and a surplus of iron in the brain. However, a causal link between the two has not been proven yet. We lack knowledge concerning the specific form of iron that is involved in the development of neurodegenerative diseases.…

The factors that dynamically sculpt the inter-regional correlation of brain patterns are poorly understood. Here, we test the hypothesis that they are shaped by the catecholaminergic neuromodulators norepinephrine and dopamine.

The Leids Astronomisch Dispuut F. Kaiser is an association dedicated to the students who study astronomy in Leiden. In addition, they are also very involved in the public activities in the Old Observatory and help with the development and implementation of other projects in the building.

Promotores: Bas Edixhoven, Guy Henniart

The old dummy MRI scanner in the LUMC was replaced by a 'new' one from Marktplaats (!) at the beginning of July 2020. This device is used specifically for children and adults suffering from claustrophobia, and to introduce the elderly to the scanner.

Novel language learning activates different neural processes than was previously thought. A Leiden research team has discovered parallel but separate contributions from the hippocampus and Broca's area, the learning centre in the left hemisphere. The right hemisphere of the brain also seems to play…

A new NMR microscope gives researchers an improved instrument to study fundamental physical processes. It also offers new possibilities for medical science, for example to better study proteins in Alzheimer patients’ brains. Publication in Physical Review Applied.

The philosopher and psychologist G.F. Stout was the teacher of Moore and Russell around 1894. This book shows that Stout's ideas have played a role in Moore and Russell's development from their early idealism towards analytic realism, where Stout's ideas often find their origin in early phenomenolog…

What happens in young people's brains when they win money for someone else? Psychologist Elisabeth Schreuders has shown that the brain responds differently according to the type of friendship and that the response is strongest with stable relationships later in adolescence. PhD defence on 6 March.

Lecture

The updated MRI scanner at the Leiden Institute for Brain and Cognition (LIBC) will become operational on 29 September. The new version is faster and better than the current model.

Lecture

In October 2019, OSCL organised a Hackathon on the ins and outs of MRI datasharing

Kan artificiële intelligentie (AI) helpen om subtiele veranderingen in de gewrichten op te merken op MRI-beelden van patiënten met reumatoïde artritis? Die vraag gaan Leidse wetenschappers beantwoorden dankzij een subsidie van de Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO).

Research facilities within reach of LIBC members:

Research in the group Clinical Neurodevelopmental Studies is focused on understanding and influencing developmental mechanisms in children and adolescents, in particular the development of psychopathology, ranging from mild to severe neurodevelopmental disorders.