720 search results for “tumor angiogenesis and immunity” in the Public website
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White blood cells in transparent embryos
Leiden molecular cell biologists in the research group of Annemarie Meijer have discovered novel early macrophage-specific genes in zebrafish, including a signal transducer pivotal for the migration of macrophages in the innate immune response to bacterial infection. Their findings were published on…
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New insights into the prognostic value of the tumor-stroma ratio in patients with breast cancer
PhD defence
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mRNA and drug delivery with lipid-based nanoparticles
This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.
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New insight into tuberculosis infection
Michiel van der Vaart with a team from Leiden University and the LUMC, led by IBL-researcher Annemarie Meijer, discovered that DRAM1 is a protein that regulates anti-bacterial autophagy, a defense mechanism against infections such as tuberculosis.
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A₃ adenosine receptor allosteric modulator induces an anti-inflammatory effect: in vivo studies and molecular mechanism of action
Source: Mediators Inflamm (2014)
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Activity-Based Proteasome Profiling
Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea
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Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
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Research
An overview of the research at the Biologics Formulation group
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Research
At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.
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Smart design carries sound one way
A new computer simulation shows the promising possibilities of the booming field of topology. Smartly designed mechanical structures carry sound exclusively one way and are immune to fabrication errors. Publication on 17 July in Nature Physics.
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Two NWO ECHO grants for Leiden Chemistry
Two excellent young chemists, Jeroen Codée and Sander van Kasteren, have received an ECHO grant for €260,000 from the Netherlands Organisation for Scientific Research (NWO). This funding will allow them to begin their research projects.
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Light-activatable metallodrugs and metal-functionalized liposomes
Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…
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Iron-immune interactions in Alzheimer's disease
PhD defence
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mutations in endometrial cancer – Insights into the biology of POLE-mutant tumors
PhD defence
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BioTherapeutics
Research in the BioTherapeutics research programme is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.
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Replacing the needle and syringe for vaccine administration
Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra
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New generation alum based vaccine adjuvants
Aluminium-based adjuvants, such as aluminium hydroxide and aluminium phosphate, are well-known for their immune-stimulating properties.
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Lab facilities Health, Medical and Neuropsychology
Psycho-physiological studies for health and disease.
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Why Leiden University?
We are committed to provide you with meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.
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New techniques for tuberculosis treatment
About nine million people worldwide contract tuberculosis each year. Research into new treatment for this disease has received fresh stimulus with more efficient techniques and a new understanding of how the tuberculosis bacteria works.
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COVID-19 vaccine
Leiden researchers are helping develop safe COVID-19 vaccines.
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PhD candidate for the project “Inflammatory mechanisms of atherosclerosis and its therapeutic potential”
Science, Leiden Academic Centre for Drug Research (LACDR)
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Leiden students develop highly contagious card game
Infecting each other with viruses and bacteria while protecting yourself with medicines and vaccinations. Sounds like a fun evening, right? Master students Life Science & Technology Rafael Jezior and Dennis de Beeld certainly think so. Together, they developed ImmunoWars: an exciting card game based…
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LUMC involved in development of novel drugs to treat and prevent SARS-CoV-2 and other coronaviruses
The Department of Medical Microbiology at Leiden University Medical Center (LUMC) is researching antiviral drugs that could treat and prevent SARS-CoV-2 in various projects. One part of the PanCoroNed project is being led by Martijn van Hemert and involves lab tests into the antiviral effect of molecules…
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‘We shouldn’t lump all microorganisms together’
Hermelijn Smits is Professor of Host-commensal Interactions and Immune Modulation. In this role she is increasing our current understanding of the way in which microbes and parasites shape our immune system to protect us from respiratory infections and chronic inflammatory diseases. In her inaugural…
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Respiratory tract infection: prevention, early detection and attenuation of immune response
PhD defence
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The immune compartment at the maternal-fetal interface throughout human pregnancy
PhD defence
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resistance of Human papillomavirus- infected or -transformed cells to Th1 immunity
PhD defence
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The NKG2A / HLA-E axis a novel target for immune checkpoint therapy
PhD defence
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Untangling the immune landscape of colorectal cancer by in situ multiplex immunophenotyping
PhD defence
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Immune modulation by helminths and the impact on the development of type 2 diabetes
PhD defence
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The Role of the innate and adaptive immune system in Vascular remodelling
PhD defence
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Immune modulation by schistosomes:mechanisms of regulatory B cell induction and inhibition of allergic asthma
PhD defence
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High-dimensional profiling of immunotherapy responsive immune cells in cancer
PhD defence
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Wiles and Wanderings: Immune-evasive maneuvers of skin-penetrating parasites
PhD defence
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Testing of a malaria vaccine gets the green light
Researchers at Leiden University Medical Center (LUMC) and Radboud university medical center have been given the green light to deliberately infect volunteers with malaria in order to test a highly promising vaccine on them.
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Participating in a European Workshop on Blockchain and the Law
Iris Wuisman and Morshed Mannan of the Company Law department attended a European workshop on blockchain and the law at the European University Institute (EUI) in Florence on 30 November 2017- 1 December 2017.
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Free online course teaches you all about imaging
How do you microscopically image zebrafish larvae? The new free online course ‘Imaging the Vertebrate embryo’ teaches you all about it. Leiden PhD candidates Salomé Muñoz Sánchez and Radoslaw Gora contributed to the course.
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Research
Research at the MCBIM group is comprised of the following research themes:
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Cutaneous CD30-positive lymphoproliferations: Therapeutic strategies and prognostic factors
PhD defence
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Light-activatable ruthenium-based anticancer prodrugs
Can light-activatable ruthenium compounds be used as a more selective anticancer treatment?
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Polypept(o)ide-based nanostructures for therapeutic and diagnostic application
Nanoparticles exhibit a number of adjustable properties, e.g., their size, shape, and surface and core chemistry, which can be further diversified with different functional moieties. This opens a broad field for application in diagnostic and therapy. In this respect, the use of a polymeric hybrid material,…
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How do we maintain a healthy biological clock?
During Seeing Stars Leiden all the lights around Leiden Observatory will be switched off for an hour. The more lights that go out, the more stars we’ll be able to see. For the LUMC, this is the perfect moment to think about our biological clock, the topic researchers from the BioClock consortium are…
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Systems biology as a compass to understand cancer-immune interactions in humans
PhD defence
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Control of Western flower thrips through jasmonate-triggered plant immunity
PhD defence
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Safety and efficacy after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model
PhD defence
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The Anti-Citrullinated Protein Antibody immune response and its effector functions in Rheumatoid Arthritis
PhD defence
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Immune parameters affecting maternal tolerance towards the fetus in normal and aberrant pregnancies
PhD defence
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Insights from modeling metabolism and amoeboid cell motility in the immune system
PhD defence
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Outcome after Paediatric Stem Cell Transplantation for Inborn Errors of Immunity
PhD defence