691 search results for “tumor angiogenesis and immunity” in the Public website
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T-cells more important in the fight against the COVID-19 virus than initially thought
A COVID-19 vaccine that specifically instructs the immune system to produce T-cells rather than antibodies is shown to provide good protection in a mouse model, Leiden University Medical Center (LUMC) researchers report in Nature Communications. According to them, the alternative vaccine may offer a…
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The Complex Interactions between the Tumor Microenvironment and Prostate and Oropharyngeal Cancer
PhD defence
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Antiepileptic and antitumor treatment in brain tumor patients: impact of clinical and radiological outcome
PhD defence
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Exploring prognostic and predictive application of the tumor-stroma ratio in colorectal cancer
PhD defence
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Amanda Foks receives prestigious Junior Postdoc fellowship
Dr. Amanda Foks obtained a fellowship from the dr. E. Dekker-program for the project ' Can promotion of efferocytosis induce regression of atherosclerosis?', in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research…
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How killer -T-cells migrate towards virus-infected cells
Joost Beltman (LACDR, Leiden University) has provided novel insights in the way T cells migrate towards virus-infected cells. This was accomplished by a combination of experimental research in the group of Ton Schumacher (Dutch Cancer Institute, NKI) and computer simulations in collaboration with Rob…
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PhD candidate for the project “Targeting immunosenescence in atherosclerosis”
Science, Leiden Academic Centre for Drug Research (LACDR)
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Individualized prognosis in childhood immune thrombocytopenia
PhD defence
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Unraveling the mysteries of Multiple Sclerosis
Leiden chemists discovered a new mechanism which might explain how multiple sclerosis shifts to a more severe form. Their findings contribute to unravelling the mysterious course of the disease. They have published their findings in the journal Biochemistry.
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Synthesis of oligosaccharide libraries from GBS capsular polysaccharides for structure-based selection of vaccine candidates
Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.
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Key publications
Key publications of the Biologics Formulation group
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Individualized dosing of serotherapy in allogeneic hematopoietic cell transplantation - a delicate balance
Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius
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Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
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Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
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Bioorthogonal Labeling Tools to Study Pathogenic Intracellular Bacteria
In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.
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Better vaccines against malaria and tuberculosis
The infectious diseases malaria and tuberculosis are responsible for 2.1 million deaths every year. Leiden researchers are currently testing a new tuberculosis vaccine.
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Innovation in treatment and care
Treatment and care for cancer patients is becoming increasingly advanced. For example, surgeons can now perform operations with much greater precision, and therapeutic vaccines are being developed to prompt the patient’s immune system to fight cancer. Work is also being done on better early diagnostics,…
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Molecular pathology in bone and soft tissue tumors: A multifunctional key for diagnosis and prediction
PhD defence
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Overcoming barriers to T cell activation, infiltration and function in tumors
PhD defence
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inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
PhD defence
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Chemokine signaling in Tuberculosis and Salmonella infection
Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?
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Student projects
Are you looking for a research project?
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Immunotherapy to limit atherosclerosis
Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…
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Bioactive Molecules in Animal Sciences
Animal Sciences’ contribution to the Bioactive Molecules research theme includes research on molecules from natural sources, such as plants, insects, and snake venom, with the aim to identify novel anti-cancer, anti-inflammatory, anti-microbial, and anti-diabetic agents.
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The good? The bad? The mutant! Characterization of cancer-related somatic mutations and identification of a selectivity hotspot in adenosine
G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.
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Discovery of BUB1 kinase inhibitors for the treatment of cancer
The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.
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The mechanism of Agrobacterium-mediated transformation of eukaryotic cells
We aim to unravel the molecular mechanisms involved in the transformation of eukaryotic cells by Agrobacterium.
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Mechanisms of Ewing sarcoma metastasis: biochemistry and biophysics
Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska
- Molecular Biotechnology
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‘Skin injection could allow us to vaccinate up to five times more people from the same supplies’
The current COVID-19 vaccination campaign involves injecting the vaccine into muscle tissue, but injecting a smaller amount of vaccine in the skin might also provide good protection. The #wakeuptocorona crowdfunding campaign has enabled Anna Roukens (LUMC) to examine the safety and efficacy of vaccination…
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Donations for research projects with relevance to society
Psychologists Marieke Tollenaar, Anne Miers and Esther van den Bos received donations from the Leiden University Fund and Stichting Praesidium Libertatis to take crucial first steps in research projects that may eventually contribute to the well-being of vulnerable youth.
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Tackling messy blood vessels to fight cancer
With a Vici grant of 1.5 million euros, Professor of Mathematical biology Roeland Merks will look for ways to fix messy and leaky blood vessels in tumours. His research combines mathematical simulations and lab experiments in a unique way.
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LUMC professor Maria Yazdanbakhsh receives Spinoza Prize
Leiden professor of Cellular Immunology of Parasitic Infections Maria Yazdanbakhsh receives the prestigious NWO Spinoza Prize this year. This, in many ways, border-crossing scientist contributes with her research to more effective vaccines against parasitic infections and better medication for inflammatory…
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Immunochemical approaches to monitor and modulate the adaptive immune system
PhD defence
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Cytokine-mediated regulation of immunity during persistent viral infection
PhD defence
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Characterization of innate immune cells in the glioma microenvironment
PhD defence
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Monitoring the immune responses to vaccination and infection
PhD defence
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T and NK cell immunity after hematopoietic stem cell transplantation
PhD defence
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Characterization of innate immune cells in the glioma microenvironment
PhD defence
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Natural and Vaccine derived immunity against the human papillomavirus
PhD defence
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BioTherapeutics (MSc)
The master’s specialisation BioTherapeutics at Leiden University is a two-year programme which trains students in research in specific drug delivery techniques. The programme also examines the development of new therapeutic approaches to treat immune-based disorders, such as atherosclerosis, metabolic…
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Overview
Our research is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.
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In vivo fluorescence imaging of IgG1 aggregates after subcutaneous and intravenous injection in mice
PURPOSE: To monitor the biodistribution of IgG1 aggregates upon subcutaneous (SC) and intravenous (IV) administration in mice and measure their propensity to stimulate an early immune response.
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International organisations and the rule of law
International organisations that represent collaborations between States are becoming increasingly more powerful, and they have an increasing impact on our daily lives. For example, the European Court of Human Rights in Strasburg established that minors have a right to legal aid immediately following…
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Amanda Foks receives Dekker grant from Dutch Hartstichting
Pharmacologist Amanda Foks is one of the ten talented scientists who received a Dekker grant from the Hartstichting. She receives €427,000 to find a way to rejuvenate immune cells to prevent infarcts. Foks was nominated as Discoverer of the Year in 2016.
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White blood cells in transparent embryos
Leiden molecular cell biologists in the research group of Annemarie Meijer have discovered novel early macrophage-specific genes in zebrafish, including a signal transducer pivotal for the migration of macrophages in the innate immune response to bacterial infection. Their findings were published on…
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ICM 2018 project results
Within the ICM 2018 project, Leiden University cooperated with 25 partner universities from 14 countries. In total, 97 mobilities were granted to this project - 65 mobilities were realised (some mobilities had to be ended prematurely due to covid-19, others were finished online).
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Immune modulation and monitoring of cell therapy in inflammatory disorders
PhD defence
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Synthesis of chemical tools to study the immune system
PhD defence