In this research I assess the impact of the recently discovered gas reserves south off Cyprus on the escalation of the Cyprus conflict.

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Governments in parliamentary democracies have limited time in office to fulfill their policy agendas. So, how do they optimise the timing of legislative bills to assure their passage and avoid lengthy parliamentary scrutiny? This question is especially puzzling under coalition governments, in which…

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The SAPPAO project aims to optimise the accuracy and reliability of predicting scheduled flight times. The full name of the project is 'A Systems Approach towards Data Mining and Prediction in Airlines Operations'.

At the end of 2018, the public voted environmental scientist Paul Behrens Discoverer of the Year. Behrens is an interdisciplinary scientist who wants to understand our impact on the planet. ‘Unfortunately, we are not doing enough. Huge changes are underway and we’re running out of time to avoid the…

We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.

This thesis focuses on the study of transient and variable radio sources in the universe.

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)

This work analyzes ritual practices and knowledge related to the Mesoamerican calendar with the aim of contributing to the understanding of the use and conceptualization of this calendar system in the contemporary K’iche’ community of Momostenango, in the Highlands of Guatemala.

Lecture, Research Seminar

The NWO-funded research project Critical Making engages with practices that cross the disciplinary boundaries of art, design, engineering and technological making, and (artistic) social intervention.

This editorial to RHCPP discusses how COVID-19 can be seen as a 'creeping crisis' according to the authors of its lead article (Boin et al, 2020) and how resilience may depend on the real heroes behind the scenes of response to disaster and adversity.

Promotor: S.M. Verduyn Lunel

Leiden chemists have created a new ultrathin membrane only one molecule thick. The membrane can produce a hundred times more power from seawater than the best membranes used today. The researchers have published their findings in Nature Nanotechnology.

This book examines how renewed forms of artistic activism were developed in the wake of the neoliberal repression since the 1980s.

The Hazelhoff Centre for Financial Law research programme for 2020-2023 centres around the integrity of financial markets during times of crisis and possible regulation to secure it.

LUCRIS Graduate School Management (GSM) is a system for the registration of all formal steps regarding admission, progress, and graduation during the PhD track. LUCRIS GSM supports various approvals (by the supervisor (promotor), dean, and secretary) that occur during the PhD track. Some documents,…

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

In 1960, not one but 17 African countries became independent. Sixty years later the African Studies Centre Leiden (ASCL) is offering a wide programme to mark this celebration. African Studies itself proved to be a topic of conversation at the kick-off conference on 30 January.

Therapeutic proteins have revolutionized the treatment of many severe diseases like multiple sclerosis, haemophilia, diabetes and many more. Unfortunately, even recombinant proteins with structures (almost) identical to those of their endogenous counterparts often induce the formation of anti drug antibodies…

The precise psychobiological mechanisms leading to chronic physiological stress responses have not been sufficiently explained, although stress is a major risk factor for disease and early death. A problem for conventional stress theory is that most of these responses seem to occur in situations without…

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

The Aging and Immunity group is led by Dr. Amanda Foks. In this group we aim to investigate how aged immune cells contribute to atherosclerosis and identify novel therapeutic targets and strategies to extend health span and inhibit cardiovascular disease.

How was time understood during the colonial period by Tlaxcaltecan Naua communities? What is the relationship between time, spirituality and ritual in the present-day Naua community of Santa Catarina? What does this tell us about the strengths and values of Indigenous heritage and about the impact of…

In the nineteenth century many Dutch people believed in the end of time and the coming of God's thousand-year reign. This belief effectively slowed down the process of modernisation that was taking place in the Netherlands at that time, concludes historian Rie Kielman. PhD defence 13 April.

Promotor: Prof.dr. E.F.A. Deprettere, Co-promoter: Todor P. Stefanov

Het project heeft plaats gevonden in de QMO groep onder begeleiding van Dr. Michiel de Dood en Dr.ir. Sense Jan van der Molen. De titel van de presentatie is:

ASLU 28 Michalis Karambinis (2015)

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

Greenhouse gasses in the atmosphere and fertilizers in the groundwater have negative consequences for our environment. With an electrochemical process they can be transformed to more valuable and useful substances like fuel and alcohol. Chemistry PhD candidate Elena Perez Gallent discovered how this…

The documentary Einstein’s Light by director Nickolas Barris shows in a dazzling manner what scientific breakthroughs resulted from the special friendship between Albert Einstein and the Leiden physicist Hendrik Antoon Lorentz. The documentary premiered at the Leiden International Film Festival on 2…

An international group of scientists, led by Leiden physicist Sense Jan van der Molen, has developed the first switchable molecular diode. You can turn this on and off through humidity. Vice versa, it is a humidity sensor at the nanoscale. Publication on 4 December in Nature Nanotechnology.

In this article, Tokdemir & Klein examine the strategic actions of governments against domestic terrorist groups and domestic terrorist groups’ reactions to such actions.

Knowledge and culture subproject 3:

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: Dr. H.Hoekstra

Astronomer Donggang Wang, physicist Anne Meeussen and chemists Nick Gerrits and Elliot Mock: all four are receiving a Rubicon grant from the Dutch Research Council (NWO). This grant for young talent will enable them to spend two years doing research at a foreign university.

Publication in Proceedings of the National Academy of Sciences.

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

This research will focus on the relationship between the musical structure and musical time in the performance of 19th century music.

In this thesis, I studied the origin and evolution of the non-thermal radiation in merging galaxy clusters.

What is the optimal way to utilise intermediate assessment in improving study behaviour and study success?

This research programme seeks to understand the dynamics in the relationship between social media, mobile telephony and the social fabric under duress in Africa's mobile margins. It combines studies on mobility/migration, conflict and communication in an attempt to uncover these new dynamics, which…

On 29 January 2019, Robbert van Eijk defended his thesis 'Web Privacy Measurement in Real-Time Bidding Systems, A Graph- Based Approach to RTB system classification'. The doctoral research was supervised by Prof. dr. H.J. van den Herik.

Lecture

The purpose of this programme is to join knowledge and insights from linguistics, literary analysis, and rhetoric, for the purpose of developing a set of methods for the stylistic investigation of any type of text in Dutch.