1,001 search results for “stress response pathways” in the Public website
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Responding to environmental cues: the adaptive qualities of chromatin compaction proteins
Promotor: M. Ubbink, Co-Promotor: R. T. Dame
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Accessible remote sensing of water
Water is all around us and is vital for all aspects of life. Studying the various compounds and life forms that inhabit natural waters lets us better understand the world around us.
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The impacts and challenges of water use of electric power production in China
This thesis examines the impacts and challenges of water use of electric power system. This thesis found that there are large differences in water use of electricity technologies, with hydropower and thermal power being two large water users.
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The role of the tumor suppressor Lkb1 in energy homeostasis
The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.
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Economie en maatschappij
Deze digitale gastlessen behandelen thema's als economie, recht, bestuur, gedrag en maatschappij.
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Het belang van vriendschappen voor het verminderen van stressreacties bij jonge mensen die een ingrijpende ervaring hebben opgedaan tijdens hun
Van alle kinderen en adolescenten die wereldwijd opgroeien, maakt ongeveer de helft ten minste één ingrijpende gebeurtenis mee in de jeugd. Deze ingrijpende jeugdervaring is een van de belangrijkste voorspellers voor psychopathologie in het latere leven.
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Digitale Gastlessen
Digitale gastlessen laten scholieren in de klas kennismaken met wetenschap. In video’s van 10 minuten worden wetenschappelijke vraagstukken over maatschappelijk relevante thema’s behandeld. Aangevuld met activerende opdrachten en werkvormen in de bijgeleverde docenthandleiding beslaan de digitale gastlessen…
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LIBC Onderzoeksfaciliteiten
Faciliteiten waar LIBC leden gebruik van kunnen maken (in het Engels):
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Singing is silver, hearing is gold: impacts of local FoxP1 knockdowns on auditory perception and gene expression in female zebra finches
The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.
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Linking the gene regulatory network with the functional physical structure of whole-genome engineered Arabidopsis mutants : an HR-MAS NMR-based
Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Heme biosynthesis and regulation in the filamentous fungus Aspergillus niger
Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel
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Novel role of the AT-HOOK MOTIF NUCLEAR LOCALIZED 15 gene in Arabidopsis meristem activity and longevity
Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska
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Interstellar Catalysts and the PAH universe
Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.
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Nucleosome stacking in chromatin fibers probed with single-molecule force- and torque-spectroscopy
In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.
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Meedenken in de focusgroep stress en angst in de klas
Debate
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Impact of plant hormones on growth and development of actinobacteria
Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.
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Terug naar de opvang: kinderopvang in tijden van corona
In dit rapport worden de eerste resultaten van een vragenlijst onderzoek naar de ervaringen van ouders en kinderen tijdens de sluiting van kinderdagverblijven in de periode van 16 maart tot en met 11 mei 2020 besproken, evenals ervaring rondom de heropening van kinderdagverblijven.
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General plant strategies and functions in wetlands: Global trait-based analyses
Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.
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and characterizing regulators of histone acylation and replication stress
PhD defence
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Combatting Clostridioides difficile: stress, adaptation and antimicrobial resistance
PhD defence
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Oxidative Stress in Chronic Diseases: Causal Inference from Observational Studies
PhD defence
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Leiden workshop in Political Science - Playing to the audience: Responses to violations of international order
Lecture
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The Anti-Citrullinated Protein Antibody immune response and its effector functions in Rheumatoid Arthritis
PhD defence
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SUMOylation in Proteostasis, Centromer Integrity and the DNA Damage Response
PhD defence
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Unravelling the anti-carbamylated protein antibody response in rheumatoid arthritis
PhD defence
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Dose-dependent and compound-specific phospho-signalling responses after (geno)toxic treatment
PhD defence
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Identification and characterization of novel factors in the DNA damage response
PhD defence
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Onderzoek
Het onderzoek van de sectie Gezondheids-, Medische en Neuropsychologie richt zich op de psychologische aspecten van gezondheid en ziekte, en op het ontwikkelen van innovatieve behandelingen.
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Metabolic signatures in nutrition and health: Short-term diet response, sexual dimorphism and hormone chronobiology
PhD defence
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
PhD defence
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Understanding Al Qaeda in the Islamic Maghreb: responses to terrorist tactics and insurgent strategies
PhD defence
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The role of zebrafish larvae for studying anxiety-like behaviour
The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.
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On the geometry of fracture and frustration
Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli
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Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
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When materials become critical: lessons from the 2010 rare earth crisis
Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn
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Large scale visual search
Promotor: J.N. Kok, Co-promotor: M.S. Lew
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Impacts of fire on invertebrate species
What impact does a mid-season wildfire have on grassland invertebrates?
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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Impact of land use changes on the human-elephant conflict
Promotor: G.R. de Snoo, W. Kustiawan, Co-promotor: H.H. de Iongh
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The role of the interleukin 12 family in atherosclerosis
Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Microbial communities in Pampa soils; impact of land use changes, soil type and climatic conditions
Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae
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Chitin in the fungal cell wall: towards valorization of spent biomass of Aspergillus niger
Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.