Promotores: A.H. Meijer, H.P. Spaink

Promotor: R. Verpoorte, Co-promotores: Y.H.Choi, N.R. Mustafa

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

To design the ideal water oxidation catalyst, understanding of the catalytic mechanism and decomposition pathways is essential.

Alumni event, Webinar

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

Debate

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

PhD defence

PhD defence

PhD defence

PhD defence

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Training

Training

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Promotor: Prof.dr. J. Kuiper

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

LIBC PUBLIEKSDAG 'STRESS IN HET BREIN; VAN BABY TOT BEJAARDE' (In Dutch)

Tijdens dit project wordt een app over stress ontwikkeld en geëvalueerd. De app heeft drie functies: een informerende, preventieve en herstellende/curatieve functie.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Promotor: P.M. Brakefield

Science, Institute of Environmental Sciences (CML)

Science, Leiden Academic Centre for Drug Research (LACDR)

Science, Institute of Environmental Sciences (CML)

Vanwege de wereldwijde corona-uitbraak veranderde halverwege maart 2020 alles in Nederland. Zoveel mogelijk thuisblijven en anderhalve meter afstand, dat werd de norm. Een jaar later kijken we met vier ‘insiders’ van de Faculteit der Rechtsgeleerdheid terug op het coronajaar. Hoe hebben ze het ervaren?…

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Wat zijn de risico's van nanodeeltjes?

Interactive exploration of large volumes of data is increasingly common, as data scientists attempt to extract interesting information from large opaque data sets. This scenario presents a difficult challenge for traditional database systems, as (1) nothing is known about the query workload in advance,…

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

PhD defence

Het was groot nieuws, vlak voor het paasweekend: cabaretier Jochem Myjer zou een keuzevak gaan geven over omgaan met stress. Honderden studenten meldden zich aan, en ook de redacties van onder andere Pauw, Omroep Max en Radio 1 wilden Myjer spreken. Helaas voor hen: het is een 1-aprilgrap. Maar met…

Jos Brosschot is benoemd tot bijzonder hoogleraar ‘psychofysiologische mechanismen van stress in het dagelijkse leven’. De leerstoel is ingesteld namens de Stichting Onderzoek naar Psychosociale Stress (SOPS).

Science, Leiden Academic Centre for Drug Research (LACDR)

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

Deze digitale gastlessen behandelen thema's als natuur, gedrag, duurzaamheid en gezondheid.

Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort