While bioinformatics methods deal with the analysis of sequence information (be it proteins or DNA), the field of cheminformatics is concerned with the analysis of small-molecule datasets.

The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).

Promotor: M. Ubbink, Co-promotor: G. Siegal

Promotor: Prof.dr. T. Hankemeier, Co-Promotor: R.J. Vreeken

Promotor: M. Ubbink, Co-promotor: G. Siegal

Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…

NNMT wordt beschouwd als een nieuw potentieel farmacologisch doelwit in de behandeling van een verscheidenheid van kankers, stofwisselingsziekten en andere pathologieën. Het toenemend aantal publicaties waarin de rol van NNMT bij ziekten wordt opgehelderd, heeft op zijn beurt de ontwikkeling van krachtige…

Bioactive Molecules is one of the four research themes of the Institute of Biology Leiden.

Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.

Promotor: M. Ubbink, Co-promotor: G. Siegal

Microbial Sciences' contribution to the Bioactive Molecules research theme is to discover new bioactive molecules and enzymes and unravel their mechanisms of action, regulatory networks, and the (bio)synthetic pathways required for their production.

Even a small quantum computer should be able to simulate exactly the properties and behaviour of new molecules. This would take chemistry to an entirely new level. Better solar panels, more powerful batteries, saving lots of energy in the chemical industry: the applications have the potential to transform…

Plant Sciences' contribution to the Bioactive Molecules research theme is to identify new plant bioactive molecules, and unravel their mechanisms of action in plant development or health, and the regulatory networks and (bio)synthetic pathways required for their production.

This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.

Animal Sciences’ contribution to the Bioactive Molecules research theme includes research on molecules from natural sources, such as plants, insects, and snake venom, with the aim to identify novel anti-cancer, anti-inflammatory, anti-microbial, and anti-diabetic agents.

Our DNA molecules are packaged by proteins in compact structures. The aim of this project is to understand how modern gene editing techniques nevertheless get access to their target in the DNA.

Schneider

Since the early 1990s, one can isolate the optical signal of a single molecule and single-molecule spectroscopy has quickly grown into an important research field.

This thesis revolves around the electronic spectroscopy of molecules in the laboratory and the search for the carriers of the diffuse interstellar bands (DIBs).

Promotor: Prof.dr. E. F. van Dishoeck, Co-promotor: A. N. Heays

Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

I will give a general introduction to the field of molecular electronics, its history, methods and challenges. I will also introduce the subject of my investigation and provide a brief outlook to the remainder of our thesis.

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

This perspective addresses four challenges facing theorists whose aim is to make quantitatively accurate predictions for reactions of molecules on metal surfaces, and suggests ways of meeting these challenges, focusing on dissociative chemisorption reactions of H2, N2, and CH4.

Promotor: Prof.dr. M.A.G.J. Orrit

An accurate description of reactive scattering of molecules on metal surfaces often requires the modeling of energy transfer between the molecule and the surface phonons. Although ab initio molecular dynamics (AIMD) can describe this energy transfer, AIMD is at present untractable for reactions with…

Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Leiden chemists, together with colleagues at the University of York (UK) and Technion (Israel) have discovered a small, sugar-like molecule that maintains the integrity of tissue around a tumour during cancer. This molecule prevents tumour cells from spreading from the primary cancer site to colonise…

PhD defence

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Specific fatty acid-sugar molecules allow leprosy bacteria, among others, to hide from our immune system. How exactly is not entirely clear. Hessel van Dijk, who received his PhD on 13 October, replicated the molecules, helping to solve a piece of the puzzle. Van Dijk's dissertation is titled: Synthesis…

Promotor: M.A.G.J. Orrit

Can we find new chemical and biological sensing routes on the edge and surface of graphene to improve the potential of graphene to act as a sensor?

Walsh

This thesis aims to improve the detection from ultra-weak single emitter by enhancing their emission properties with plasmonic nanostructures. We exploit the wet-chemically synthesized single crystalline gold nanorods (GNRs) as our basic frameworks in the whole studies, simply because of their unique…

Promotor: Prof.dr. G.J. Kroes

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

The small piano studios at the LAK are available to rent for practice purposes. You can either rent the studios per hour or get a subscription. There are Yamaha pianos available in the studio's, but you can also use the space to practice with your own instrument.

The LUCDH foster the development of new digital research by awarding a number of Small Grants each year. As in previous years the LUCDH received a large number of excellent grant applications for Research and Personal Development funds. Congratulations to the recipients of this year's research award…

Political scientist Wouter Veenendaal (Leiden University) provides an in-depth case study of clientelism in Malta, the smallest member state of the European Union. He reveals that not only that patron–client linkages are a ubiquitous feature of political life in Malta, but also that the smallness of…

Planets are formed in disks of gas and dust around young stars.

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