557 search results for “single cell transcriptomics” in the Public website
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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The innate immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
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Tenosynovial Giant Cell Tumours
PhD Defence
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Microscopy and Spectroscopy on Model Catalysts in Gas Environments
In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.
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Anisotropy in cell mechanics
PhD Defence
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The imperfect fuel cell model
Lecture, This Week's Discoveries
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Gold nanoparticle-peptide conjugates for biomedical applications
Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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Cell Observatory Mini-Symposium
Conference
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microenvironment in colorectal cancer: an integrative histopathological, transcriptomic and metabolomic approach
PhD Defence
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Molecular electronics: Controlled manipulation, noise and graphene architecture
Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.
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B cell modulation in atherosclerosis
PhD Defence
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Origami metamaterials : design, symmetries, and combinatorics
In the first part of this thesis we study the geometry of folding patterns.
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Exploring Deep Learning for Intelligent Image Retrieval
This thesis mainly focuses on cross-modal retrieval and single-modal image retrieval via deep learning methods, i.e. by using deep convolutional neural networks.
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NGL lezing: Single molecules and single gold nanoparticles in the spotlight
Lecture
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The ambiguous beta-cell
PhD Defence
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Orrit ontvangt OTP subsidie van NWO-TTW
Michel Orrit heeft een subsidie ontvangen uit het NWO-TTW Open Technologieprogramma. Hij gaat de kleine half miljoen euro gebruiken om individuele moleculen in beeld te brengen zonder fluorescentie te gebruiken.
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Two-photon multifocal microscopy for in vivo single-molecule and single-particle imaging
PhD Defence
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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Analysis of sub-visible particles in complex injectable formulations
Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik
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Hot Nanoparticles
Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence.
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T-Control: T-Cell Therapy in the Context of Allogeneic Stem Cell Transplantation
PhD Defence
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of metabolic pathways and sensors in regulation of dendritic cell- driven T cell responses
PhD Defence
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Control of cytomegalovirus viremia after T cell depleted allogeneic stem cell transplantation
PhD Defence
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enhancement of one-photon- and two-photon-excited single-molecule fluorescence by single gold nanorods
PhD Defence
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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Imaging of alkyne-functionalized ruthenium complexes for photoactivated chemotherapy
In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.
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The role of autophagy during carbon starvation in Aspergillus niger
Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.
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CO2 reduction on post-transition metals and their alloys: an industrial approach
This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals
- Onderzoeksfaciliteiten
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Photothermal circular dichroism studies of single nanoparticles
PhD Defence
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Postdoctoral Research Associate in the mechanics of living materials
Science
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Full professor in Discovery of Biologics
Science, Leiden Academic Centre for Drug Research (LACDR)
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Software
Image-Pro Plus, ImageJ, Cell Profiler, R, Knime en NIS-elements
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A chemical biology approach for targeting of ligand-drug conjugates
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot
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Towards Optical Detection of a Single Electron
PhD Defence
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Michel Orrit ontvangt Spinozaprijs in Koninklijke Schouwburg
Op 12 september heeft Michel Orrit zijn Spinozaprijs in ontvangst genomen uit handen van OCW staatssecretaris Sander Dekker in de Koninklijke Schouwburg in Den Haag. Met de prijs is een premie gemoeid van 2,5 miljoen euro, die vrij is te besteden aan wetenschappelijk onderzoek naar keuze, en het felbegeerde…
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Langerhans Cell Histiocytosis; Genetic and Immunologic Fingerprinting
PhD Defence
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Mesenchymal Stromal Cell in Pediatric Disease
PhD Defence
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Mesenchymal stromal cell treatment for COPD
PhD Defence
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Less is more: reduced mycelial heterogeneity for improved production of enzymes and antibiotics
Hoe kan de techniek van cell wall engineering worden ingezet zodat de industrie streptomyceten beter kunnen verwerken tot nieuwe antibiotica?
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Developing metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
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Human T-cell responses to Aspergillus fumigatus
PhD Defence
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Effects of heavy fields on inflationary cosmology
Promotor: A. Achúcarro, Co-Promotor: J.W. van Holten
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Optical properties of DNA-hosted silver clusters
Promotor: D. Bouwmeester, Co-promotor: D. Kraft
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Taking control of charge transfer: strategic design for solar cells
Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda
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De nanowereld visualiseren
Eiwitten in cellen visualiseren zonder invasieve technieken? Dat kan met behulp van fluorescentie. Michel Orrit, winnaar van de Spinozapremie 2017 én grondlegger van het vakgebied single molecule optics, legde op 18 januari aan de leden van het Natuurwetenschappelijk Gezelschap Leiden en andere geïnteresseerden…
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Trans-kingdom DNA transfer
The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.
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Discovery and exploitation of the transcriptional regulatory system of pectinases in Aspergillus niger
Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.
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Dynamics of TNFalpha signaling and drug-related toxicity
In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.