720 search results for “scanning electronen microscopie” in the Public website
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Visualizing strongly-correlated electrons with a novel scanning tunneling microscope
PhD defence
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Understanding superconductivity comes closer with major ERC grant for Milan Allan
Physicist Milan Allan will build an instrument that will bring superconductivity research further. He has been awarded an ERC Consolidator Grant of 2 million euros over the next five years. With his PairNoise programme he aims to detect paired electrons as they occur just above the temperature at which…
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Joan van der Waals colloquium
The Joan Van der Waals colloquium is an ongoing bi-weekly lecture series.
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5 Grants for Leiden Physics in 10 years ERC
This weeks marks the 10th anniversary of the European Research Council. For the past decade, the council has contributed to many scientific projects all over Europe, including Leiden University. It has funded almost 7,000 researchers, leading to just short of 100,000 scientific articles. A total of…
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Real-time tomographic reconstruction
With tomography it is possible to reconstruct the interior of an object without destroying.
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The use of Deep Learning in the automated detection of archaeological objects in remotely sensed data
Generally the data from remote sensing surveys - the scanning of the earth by satellite or aircraft in order to obtain information about it - is screened manually in archaeology. However, constant monitoring of the earth's surface causes a huge influx of data of high complexity and high quality. To…
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Disorder and interactions in high-temperature superconductors
This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.
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The activation mechanisms of G protein-coupled receptors: the case of the adenosine A2B and HCA2/3 receptors
Promotor: A.P. IJzerman
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Error bounds for discrete tomography
Promotores: K.J. Batenburg, B. Koren
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Archaeological Sciences
The Department of Archaeological Sciences seeks to achieve the highest standards of excellence in science-driven education and archaeological research across the globe and across all periods.
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High-field neuroimaging of computational processes that drive cognitive control.
How do humans control their thoughts and actions, and what can high-field brain scanning reveal about the underlying processes?
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Bioarchaeology
Bioarchaeology covers the study of all biological remains from archaeological sites.
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Appreci8: working on youngsters’ perspectives together
How do young people pursue their interests in and across multiple contexts while participating in tailor-made programs in vocational education and training (VET) and social enterprises to regain perspective in school and work?
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Laser-generated toroidal helium plasmas
This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.
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Filter-based reconstruction methods for tomography
Promotor: K.J. Batenburg
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LUCDH Workshops
LUCDH facilitates workshops that promote the acquisition of skills and knowledge in employing digital tools.
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Alex Brandsen: 'Archaeological search engine adds a new dimension to ‘digging’'
Apps that can precisely identify shards, coins or heel bones: archaeology has embraced artificial intelligence. Alex Brandsen is working on a search engine that scans vast quantities of text from an archaeological viewpoint.
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Data Atlas of Byzantine and Ottoman Material Culture
Archiving Medieval and Post-Medieval Archaeological Fieldwork Data from the Eastern Mediterranean (600-2000)
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Making the most of the first time a medicine is administered to humans
Collecting as much information as possible about administering a new medicine to people can save a lot of money.
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Converting cultural heritage into usable data
How can we make the information in handwritten historical research reports accessible and searchable? Data scientists at Leiden University are working with other universities on a method that will improve access to cultural heritage.
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Searching for disease indicators in healthy people
LUMC researchers are looking for factors that point to illness at an early stage.
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Joost Batenburg about AI Leiden style: 3D images and ensuring AI belongs to everyone
Joost Batenburg is a mathematician and computer scientist who works to build bridges to other disciplines. He hopes to bring intelligent software to fields where it can make a difference. Conversely, he also seeks connections to the disciplines that are needed to make AI a success.
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Searching for disease indicators in healthy people
LUMC researchers are looking for factors that point to illness at an early stage.
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Digitalization of the papyrus collection
The papyruscollection of the Leiden Papyrological Institute is a modest collection, housed in the University Library of Leiden University. It was built up as a study collection and used in the first place for teaching and reaching a larger public.
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Research
Developing computational algorithms for structural biology -A high resolution, three dimensional view of a molecule provides detailed information that help elucidate its function: by knowing the exact arrangement of atoms in a molecule, we can understand disease, develop drugs to combat them and improve…
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Towards a single-molecule FRET study of Frauenfelder's nonexponential rebinding of CO in myoglobin
Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.
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Drug Discovery & Safety
In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.
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Student projects
To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.
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Cryo-EM of cholera infection
The structure of bacterial cells provides crucial clues about their interaction with their host. What are the key structural features of a bacterial cell that determine pathogenicity? What roles do these structures play in the life cycle, and how do they change during the infection process?
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Stable single molecules for quantum optics and all-optical switches
Promotor: Prof.dr. M.A.G.J. Orrit
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Evaluation of synergistic effects of Chinese herbal medicine and natural compounds on cancers
What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer
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Molecular Cell Biology
A thorough understanding of the workings of the cell underly the understanding of disease at the molecular level. Revealing the principles of biochemical processes helps to identify the targets for the development of new drugs. At the Leiden Institute of Chemistry (LIC), we believe that the application…
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Setup: Low Temperatures
A lot of our research is performed at temperatures close to absolute zero, among other reasons because this increases the sensitivity of the measurements.
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Synthetic, Physical and Computational Chemistry of Propeller-shaped Polycyclic Aromatic Hydrocarbons
This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…
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Briegel winner in global competition by the Moore Foundation
Ariane Briegel, Professor of Ultrastructural biology in Leiden, has received a prestigious incentive from the Gordon and Betty Moore Foundation. With the grant of 800,000 euros, Briegel will set up a new research line into studying symbiotic interactions on the nanoscale.
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Ten million euros for unlocking novel technologies in structural biology
The European Union has invested ten million euros in the so-called iNEXT-Discovery consortium. The goal of this new consortium is to enable European researchers to extend innovative structural biology research. The Netherlands Centre for Electron Nanoscopy (NeCEN) is also part of iNEXT-Disovery, which…
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Leiden researchers visualise the 'guardian of our genome’
The guardian of our genome, the protein MutS, scans the DNA for spelling errors and makes sure they are corrected. An essential process for our health. Researchers at Leiden University Medical Centre (LUMC) have discovered precisely how this protein works by making MutS visible with cryo-electron microscopy.…
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Teaching
Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).
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Physicist Sense Jan van der Molen plays ‘Dutch shuffleboard’ with electrons
Physicist Sense Jan van der Molen researches materials that do not exist in nature. ‘It’s fascinating to see how the properties of a material change if we manage to make it super thin.’ He will give his inaugural lecture on 21 October.
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Oxidation catalysis on Pt and Au: complexity of simple chemistry
Promotor: J.W.M. Frenken Co-Promotores: I.M.N. Groot; L.B.F. Juurlink
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LCA of Printed and E-paper Documents
Comparing the global warming potential (GWP) of the service provided by an iRex Digital Reader to the same service provided by an office printer using a scanning LCA.
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Collaboration
Our AI researchers work closely with other institutions such as Delft University of Technology and Erasmus University.
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Molecular electronics: Controlled manipulation, noise and graphene architecture
Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.
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Leiden - The Hague cycle route
Get on your bike… or your tandem, unicycle, electric bike, tricycle, penny-farthing, rickshaw or road bike! We’re going on a bike trip!
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Support & Representation
This section contains information on:
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Developing new therapies to fight muscle disease
Biophysicist Alireza Mashaghi and his collaborators are taking up the fight against muscular dystrophy: genetic disorders that cause muscle weakness. They want to inhibit the clumping of proteins that results in toxic aggregates. For this, the team receives 550,000 euros from Health Holland. The team…
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Working at the Faculty of Science
Working for a top faculty? Discover the vacancies at the Faculty of Science and apply immediately.
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Solid State NMR and modelling of photoinduced energy and electron transfer
Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…
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Research
An overview of the research at the Cancer Dug Target Discovery group.