Promotores: Prof.dr. G. Miley & Prof.dr. J.M. van den Broek

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Promotor: Prof.dr. J. den Hertog

Governance and Global Affairs, Leiden University College The Hague

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Van 2 tot 5 september 2015 is Leiden het toneel van een van de grootste linguïstische congressen ter wereld: de Societas Linguistica Europaea (SLE) Annual Meeting 2015. Hoe heeft Leiden zo'n prominente positie binnen de Taalkunde gekregen? Een gesprek met taalwetenschapper Arie Verhagen.

What is the best way to combine the environmental and economic data and how can we create an operational system to do so, thereby supporting the delivery of data to the Data centres on Products and Resources?

Creating information portals for support of European environmental policy.

In deze opleiding ontwikkel je je onderzoek skills en verbreed je je kennis over de meest moderne en geavanceerde technieken die je nodig hebt als onderzoeker op het gebied van target finding en het ontwerp en de synthese van nieuwe geneesmiddelen.

Deze opleiding is gericht op de ontwikkeling van computermodellen die de werking van medicijnen voorspellen, het individualiseren van bestaande behandeltherapieën en het ontwikkelen van innovatieve, analytische tools voor het personaliseren van de gezondheidszorg.

Consequences for sediment stability and seston trapping

Promotores: H.A. Udo De Haes, P.M. Brakefield

Promotor: Prof.dr. C.U. Keller

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

Science, Leiden Observatory

Arts and leisure, Arts and leisure

Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.

Natural resources often stretch across borders that separate modern nation states. This can create conflict and limit opportunities for regulated consumption of their goods and services, but also provide opportunities for joint multinational efforts that exceed single country capabilities.

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Science, Institute of Biology Leiden (IBL)

Science

Science

Sustainable energy from wind and solar is most readily available near the sea.

Promotor: M.A.G.J. Orrit

Science, Institute of Environmental Sciences (CML)

Het onderzoekscluster ‘Conflict, Conflict Resolution and Crisis Management’ maakt deel uit van het onderzoeksprogramma ‘Institutions, Decisions and Collective Behaviour’. De betrokken onderzoekers bestuderen hoe politieke conflicten ontstaan en welke typen crises we kunnen onderscheiden. Hoe hanteren…

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Op 19 mei 2020 verdedigde Xuechan Ma haar proefschrift 'Moving towards Coexistence and Cooperation: The Spratly Islands and International Law'. Het promotieonderzoek is begeleid door promotor prof.dr. N.J. Schrijver.

Science, Institute of Biology Leiden (IBL)

The thesis describes experimental steps towards reduction of friction on the macroscopic scale by scenarios of thermo- and superlubricity well-known on the nanoscale.

Cardiovascular disease is the leading cause of death worldwide.

In this thesis we use Josephson and noise scanning tunneling microscopy for the study of conventional, unconventional (iron-based) and disordered superconductors. On the one hand, Josephson scanning tunneling microscopy allows us to directly visualize the superfluid density with high spatial resolut…

Promotor: E. Gittenberger, Co-promotores: B.W. Hoeksema; L.P. van Ofwegen

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

The majority (80%) of e-waste generated globally are recycled informally in developing countries.

Promotor: Prof.dr. E. F. van Dishoeck

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

Het Institute of Security and Global Affairs (ISGA) opereert binnen de internationaal georiënteerde wetenschappelijke richting security studies en houdt zich bezig met multidisciplinair onderzoek en onderwijs.

Science, Leiden Institute of Advanced Computer Science (LIACS)

De masteropleiding Europaeum European History and Civilisation is een unieke éénjarige opleiding, aangeboden door de Universiteit Leiden, Université Paris I – Panthéon/Sorbonne en de University of Oxford.

Het doel van deze faciliteit is om het biomedisch onderzoek te versnellen door toegang te bieden tot geavanceerde licht- en elektronenmicroscopie en door het delen van expertise over monstervoorbereiding, beeldvormingsmodaliteiten, gegevensopslag en beeldanalyse.

Latent variable modeling of students' solution strategies and performance

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

In de onderzoeksmaster Hebrew and Aramaic Studies (research) van de Universiteit Leiden is gericht op het bestuderen van de Hebreeuwse en Aramese taal en cultuur in de ruimste zin.

Deze masterspecialisatie leert je veelvoorkomende leerproblemen herkennen en behandelen.

Lecture

Study information