What are the behaviours of plant traits throughout various points in the growing season in a radiative transfer model framework and how well can this knowledge be integrated through data assimilation to provide priors for robust local and global vegetation products and analysis?

Promotores: S.J. Edixhoven, F. Andreatta

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Marokko is een van de weinige landen in Noord-Afrika die aan de Arabische lente een vreedzame vorm heeft weten te geven door het pad van brede, gestage politieke hervormingen op te gaan. De Marokkaanse overheid verklaart de relatieve maatschappelijke rust daarnaast ook door haar islampolitiek, gericht…

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Including modelling as part of software development appears to have various benefits.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

De onderzoeksgroep Digital Archaeology beheert twee computerlaboratoria voor verschillende doeleinden: een onderwijslab en een onderzoekslab.

Promotor: S.M. Verduyn Lunel

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Lecture, Studium Generale

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Inaugural Lecture

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

Het ontwikkelen, gebruiken en evalueren van groepsopdrachten in het hoger onderwijs.

Promotor: P.D. Grünwald

This thesis consists of five chapters on how to construct prediction sets for different types of data and models in a parametric or nonparametric Bayesian paradigm.

This thesis discusses the discovery potential of Intensity Frontier experiments.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)

The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

PhD Defence

What happens to electrical waves that have to cross gaps in insulation material around nerves in the human body

Lecture, This Week's Discoveries

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.

Promotors: Prof.dr. J. Zaanen, Prof.dr.ir. H. Hilgenkamp

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

Promotor: J. N. Kok, Co-promotor: A. J. Knobbe

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

In het Scheepvaartmuseum van Amsterdam bevindt zich een getuigd model van een driemasterschip uit de tweede helft van de zestiende eeuw: het oudste scheepsmodel in de museumcollectie. Historicus Louis Sicking deed in opdracht van het museum onderzoek naar dit bijzondere object.

In this work, we attempt to answer the question:

In this dissertation non-parametric Bayesian methods are used in the application of robotic vision.

Mensen nemen de wereld waar via verschillende zintuigen: we zien, voelen, horen, proeven en ruiken. De verschillende zintuigen waarmee we waarnemen bestaan uit meerdere informatie kanalen, ook wel multimodaal genoemd. Betekent dit dat wat we waarnemen als multimedia kan worden gezien?

Tegenstanders van ingrijpende stikstofmaatregelen stellen dat het stikstofrekenmodel niet betrouwbaar genoeg is. Stikstofhoogleraar Jan Willem Erisman: ‘Het is nu veel belangrijker om te discussiëren over de keuzes die we maken op basis van de uitkomst. Dat levert namelijk veel grotere verschillen op…