Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst

Timely, adequate and optimal treatment of infectious diseases is essential for the survival of patients with bacterial infections (Surviving Sepsis campaign).

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

The proportion of children who are overweight has increased enormously over the past 20 years. The number has currently stabilised but even so there are still too many overweight and obese children. Could there be some connection with the way they are brought up? Roxanna Camfferman's PhD research shows…

‘The idea that overweight and obesity are the fault of parents and/or the child, is rubbish.' Roxanna Camfferman, who specialises in child and adolescent studies, explains her proposition. Her PhD dissertation is on the role of upbringing in child obesity.

Doctors and pharmacists should take greater account of obesity when dosing medicines. The distribution in the body and the breakdown of a medicine can vary considerably in obese patients. This is stated by clinical pharmacologist Catherijne Knibbe in the Annual Review of Pharmacology and Toxicology.

PhD research recently completed by pharmacologist Margreke Brill shows that morbidly obese patients should be given a different dosage of the drugs Cefazolin and Midazolam. This could also apply to other drugs such as anti-cancer drugs as well as antibiotics and Margreke Brill is advocating a change…

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Key publications of the Quantitative Clinical Pharmacology group

PhD defence

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

PhD defence

Many children eat too many high-calorie foods and too few vegetables from an early age. PhD candidate Merel van Vliet researched the role of parents in this. ‘Don’t force children to clean their plates.’ PhD defence on 15 June.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Medical Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University. The section is headed by Prof. Dr. Hans Aerts.

Knowledge on how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically-ill patients, is not only crucial for novel compounds, but also for existing drugs which are often used in an off-label manner in these special patient…

Central elements in the research activities of all programme group members are: attachment, sensitive caregiving, and prevention and intervention.

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

Dr. in Biomedical NMR spectroscopy, LUMC, Leiden - The Netherlands

The Quantitative Clinical Pharmacology group is led by Prof. Dr. Catherijne Knibbe. Her research group aims to define how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically ill patients. Through combining the statistical…

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

Today, humanity produces sufficient calories, in theory, to feed the 7.7 billion people on the planet: the amount of food produced per person on the planet has gone up more than 40% since the 1960s. Yet, ironically, the prevalence of undernourishment – which had been declining for decades – has started…

What are the functions of the endocannabinoid system?

PhD defence

LUMC researchers are looking for factors that point to illness at an early stage.

What does it mean to eat healthily and responsibly? This question is gaining a new urgency now that in many countries undernourishment is being overtaken by diseases of affluence, such as obesity, and we are also becoming more aware of the environmental impact of our eating habits. It’s time to take…

LUMC researchers are looking for factors that point to illness at an early stage.

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We work on clinical problems that require further mechanistic understanding and strive for ultimate benefit to patients.

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

Previous research has found important inter-individual differences in the pharmacokinetics (PK) of morphine in special populations such as children, the morbidly obese or the critically ill.

The precise psychobiological mechanisms leading to chronic physiological stress responses have not been sufficiently explained, although stress is a major risk factor for disease and early death. A problem for conventional stress theory is that most of these responses seem to occur in situations without…

PhD defence

On the annual spring meeting of the Dutch Society for Clinical Pharmacology and Biopharmaceutics (NVKFB), Margreke Brill received the TOP Publication Award.

Industrialised countries mine raw materials in areas inhabited by Indigenous Peoples and appropriate the knowledge and culture of these peoples. Leiden anthropologists work to protect their rights.

Industrialised countries extract natural resources in the territories of indigenous peoples, and appropriate the knowledge and culture of these peoples. Leiden anthropologists work to protect the rights of indigenous peoples. Their knowledge and advice enable governments to source sustainable produc…

Leiden chemical biologists led by Dr Mario van der Stelt have developed a method to facilitate the search for new drugs. This method has allowed them to take an important first step in the development of a drug against obesity.