We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.

We study how communication can heal and harm when patients are confronted with an illness. Most of our studies focus on serious illnesses such as advanced cancer. Communication lies at the heart of medicine, yet we do not always know which specific communication helps patients. Moreover, many complaints…

What are the capabilities or limitations of traveling between islands and how does this reflect seasonal variation? Is it possible to show higher levels of connectivity between islands based on generated pathways between several sites on two separate islands?

Promotor: Prof.dr.ir. J.W.M. Hilgenkamp, Prof.dr. J. van den Brink

This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Can excessive worrying be reduced via stimulation of the vagus nerve?

What is the effectiveness of two school-based skills-training programs in promoting mental health?

This project seeks to integrate scientific research and practical knowledge in the study of the mechanisms that make dialogue an effective tool for communication, teaching, and thinking.

How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?

In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.

Prostate cancer (PCa) is one of the most prevalent cancer in males.

He’s a fast and animated speaker, which is only logical because Gerard van Westen is driving an express train. His destination? A virtual human, consisting of algorithms that predict what an administered substance will do in the body. The train is already a long way down the line and the pharmaceutical…

This thesis describes the use of the evolutionary approach in the study of language change, aiming to provide a better insight in the mechanisms that play a role in language change and to validate this approach in the field of language change.

Assessing the feasibility and legitimacy of the current model of global tax governance and the role of the OECD and EU in international tax law-making.

What is the effect of light at night on plant phenology and physiology, and how does this affect plant interactions with other species?

The organisations and people who implement government policy face many different types of change. Academics from Leiden University research how they deal with these and advise them on how best to meet the needs and wishes of society.

What opportunities and threats flow from the existence of institutional and normative diversity in the area of fundamental rights for the effective protection of those rights in a pluralist world?

Promotor: S.M. Verduyn Lunel

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

A child who receives fewer nutrients in the womb than their identical twin brother or sister is more likely to have developmental problems later in life. This is what researchers from the Leiden University Medical Center (LUMC) write in The Lancet Child & Adolescent Health. This study shows that unfavourable…

How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?

Kohei Suzuki, Assistant Professor at Institute of Public Administration, and two other authors researched the topic of innovation by governments in response to expected population decline.

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

Koper

On 6 June 2019, Edward Donelan defended his thesis 'Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation'. The doctoral research was supervised by Prof. W.J.M. Voermans.

Promotor: Prof.dr. A.W. van der Vaart

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

This project is a collaboration between Sanquin, LUMC and LIACS. It focuses on the development of meta-modelling methods and tools for the exchange, analysis, and publication of anonymised patient data. Measures are being constructed to evaluate both the level of privacy and the extent to which an anonymized…

Promotor: J. A. Bouwstra

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

The Repository from the Drug Disease Model Resources (DDMoRe) consortium provides a home to a collection of computational models of disease and drug action that have been used in pharmaceutical and/or academic research. This publically available open-access resource will make it easier for researchers…

Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…

We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.

In this research project characteristics of effective instructional development were identified that are appealing to medical teachers and relevant for medical education.

Homicide followed by the suicide of the perpetrator often leads to shock and incomprehension. It has been suggested that media reporting on such cases could lead to an imitation effect.

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

Promotors: Prof.dr. P.G.L. Klinkhamer, Prof.dr. P.M. Brakefield

Source: International Journal of Cosmetic Science, Volume 37, Number 1, pp. 158-158 (2015) ISBN: 0142-5463

We are developing the conceptual framework, which is new to this taxonomic group, and evaluate the current state of the art with respect to all critical parameters and transfer functions for a fully developed Population Consequences of Acoustic Disturbance (PCAD) model.

How are links between macro-invertebrate diversity and ecosystem functioning influenced by anthropogenic pressures?

What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

Can we distinguish the effects of pesticides from other abiotic and biotic factors that occur in the field? And how do these factors interact with pesticides?