Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Deze opleiding biedt de mogelijkheid om onderzoek op moleculair, cellulair en organismaal niveau te verenigen, maar biedt ook de mogelijkheid om je te specialiseren op één van deze niveaus.

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

Op 9 mei 2018 verdedigde Roy van Keulen zijn proefschrift 'Digital Force: Life, Liberty & Livelihood in the Information Age'. Het promotieonderzoek is begeleid door promotor prof.dr. A. Ellian.

Promotor: B. van de Water

Mechanical interactions between cells and their environment play an important role in many biological processes.

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

Political scientist Corinna Jentzsch (Leiden University) about the organisation of rebel and government auxiliaries in the civil war in Mozambique (1976–1992).

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Een verhaal van Twee Mosuls, De wederopstand van de Irakese strijdkrachten en de militaire nederlaag van ISIS. In dit artikel, gepubliceerd in het Journal of Strategic Studies, bespreken de auteurs Maarten Broekhof, Martijn Kitzen en Frans Osinga de militaire aanpassing door de Iraakse strijdkrachten…

Op 21 juni sprak Jorrit Rijpma op de eerste bijeenkomst van het Task Force over een Europese Grens- en Kustwacht, opgericht door het Centre for European Policy Studies in Brussel.

Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort

Inaugural Lecture

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Promotor: Prof.dr. R.M.H. Merks

Promotor: Prof.dr. B. van de Water

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

PhD Defence

PhD Defence

Graphene nanoribbons (GNRs) are used as a current carrying substrate in investigation of current-induced forces in a low-temperature STM (chapter 2).

At the largest scales, two ingredients dictate the distribution of matter in the Universe. The first is dark matter, acting as an invisible scaffolding held together by gravitational forces.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

Promotor: G.J.B. van Ommen

PhD Defence

PhD Defence

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

De master Biology is een samenwerking tussen het Instituut Biologie Leiden, Naturalis en het Centrum voor Milieuwetenschappen Leiden waardoor het programma een brede en diverse scope heeft. De opleiding biedt zeven specialisaties, waarvan vier researchspecialisaties die nauw verbonden zijn met het onderzoek…

PhD Defence

PhD Defence

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Has the industrial sector in China effectively been decarbonizing in recent years, across different regions and subsectors, and is it plausible that it will reduce its CO2 emissions in conformity with national and internationally pledged emission goals?

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

PhD Defence

PhD Defence

PhD Defence

PhD Defence

PhD Defence

PhD Defence

Combinatie van twee potentiële geneesmiddelen geeft zicht op een 'superblokkade' van een overactief immuunsysteem, schrijven Leidse wetenschappers in Nature. De doorbraak was het kristalliseren van het betrokken membraaneiwit.

PhD Defence