223 search results for “breast cancer metastasis” in the Public website
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
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RNA splicing in breast cancer progression
In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.
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Exploring Grainyhead-like 2 target genes in breast cancer
The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Mechanisms of Ewing sarcoma metastasis
Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska
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uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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Cell-autonomous and host-dependent CXCR4 signaling in cancer metastasis: insights from a zebrafish xenograft model
Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska
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PI3K signaling and adherens junctions in invasive lobular breast cancer
PhD Defence
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xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Prostate cancer (PCa) is one of the most prevalent cancer in males.
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Identification of novel targets in prostate cancer progression
Promotor: B. van de Water, Co-promotor: E.H.J. Danen
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Novel regulators of prostate cancer stem cells and tumor aggressiveness
Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm
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of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
PhD Defence
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Tumor-immune interactions in colorectal cancer
PhD Defence
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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Cancer and sexual health: the continuum of care
PhD Defence
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Molecular Biomarkers and Treatment Strategies in Resectable Pancreatic Cancer
PhD Defence
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
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Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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Carcinogenicity of insulin analogues
Promotor: Prof.dr. B. van de Water
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Role of integrin adhesions in cellular mechanotransduction
Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen
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and predictive application of the tumor-stroma ratio in colorectal cancer
PhD Defence
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Mechanisms regulating TGF-β and Wnt signal transduction in breast cancer
PhD Defence
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Quality assurance in breast cancer care and breast implant surgery
PhD Defence
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Visualization of Vitamin A Metabolism
Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.
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Remote Control: the cancer cell-intrinsic mechanisms that dictate systemic inflammation and anti-tumor immunity
PhD Defence
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Cancer Drug Discovery Initiative maakt nieuwe therapieën tegen kanker mogelijk
Het Antoni van Leeuwenhoek/Nederlands Kanker Instituut, het Leids Instituut voor de Chemie en het Pivot Park Screening Centre gaan kennis en infrastructuur delen in het Cancer Drug Discovery Initiative. Vrijdag 11 oktober tekenden ze een letter of intent.
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RNA splicing in breast cancer progression
PhD Defence
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Tamoxifen pharmacogenetics and pharmacokinetics in early-breast cancer
PhD Defence
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Uncovering vulnerabilities in triple-negative breast cancer
PhD Defence
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Immune cell complexity in the tumor microenvironment of breast cancer
PhD Defence
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Exploring Grainyhead-like 2 target genes in breast cancer
PhD Defence
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Precision modeling of breast cancer in the CRISPR era
PhD Defence
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Genen met effect op uitzaaiing borstkanker ontdekt
Onderzoekers van de Universiteit Leiden hebben genen in kaart gebracht die uitzaaiingen van borstkankercellen veroorzaken.
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Targeted Therapy for Triple-Negative Breast Cancer
PhD Defence
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Haico van AttikumFaculteit Geneeskunde
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xenograft model: identification of novel mechanisms driving prostate cancer metastasis
PhD Defence
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Cell-autonomous and host-dependent CXCR4 signaling in cancer metastasis
PhD Defence
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Erik Danen benoemd tot hoogleraar Cancer drug target discovery
Met ingang van 1 april 2018 is Erik Danen benoemd tot hoogleraar Cancer drug target discovery bij het Leiden Academic Centre for Drug Research (LACDR). Zijn vakgebied is celbiologie van kanker, waarin hij zich richt op de achterliggende mechanismen bij uitzaaiingen en resistentie voor behandelingen.
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Immuunsysteem speelt dubbele rol bij borstkanker
Het immuunsysteem speelt een paradoxale rol bij de uitzaaiing van borstkanker. Dat ontdekte Kelly Kersten in haar promotieonderzoek. Sommige immuuncellen dragen bij aan uitzaaiingen, terwijl andere cellen kunnen worden aangezet om chemotherapie effectiever te maken. Promotie op 7 februari.
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Ductal carcinoma in situ of the breast: cancer precursor or not?
PhD Defence
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Patterns of care and prognosis of older women with breast cancer
PhD Defence
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The diverse roles of integrin α3β1 in cancer: lessons learned from skin and breast carcinogenesis
PhD Defence