Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…

Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan

The Repository from the Drug Disease Model Resources (DDMoRe) consortium provides a home to a collection of computational models of disease and drug action that have been used in pharmaceutical and/or academic research. This publically available open-access resource will make it easier for researchers…

We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.

Source: International Journal of Cosmetic Science, Volume 37, Number 1, pp. 158-158 (2015) ISBN: 0142-5463

We are developing the conceptual framework, which is new to this taxonomic group, and evaluate the current state of the art with respect to all critical parameters and transfer functions for a fully developed Population Consequences of Acoustic Disturbance (PCAD) model.

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix.

Science, Leiden Academic Centre for Drug Research (LACDR)

Simulation is a formal scientific method used to develop, compare and test hypotheses (models). In the last few decades the use of simulation has increased dramatically in virtually all scientific disciplines, but is still limited in archaeology due to the technological barrier – coding skills. Starting…

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

Electrical signals travel like a wave through our neural pathways. The mathematical models for these movements could not yet properly describe all the biological properties of the nerves. PhD student Willem Schouten-Straatman changed this by improving the existing models. ‘I hope that one day we will…

The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.

The discussion on employability of higher education graduates has been around for several years, with more emphasis in the 21st century. Yet, universities are still challenged in the pursuit of providing work-ready graduates who can meet industry expectations.

The financial system needs complexity theory to predict economic crises like the 2008 meltdown. An international team of scientists, including Leiden physicist Diego Garlaschelli, state this in a paper published in Science on February 19th.

When new features are being written into software code, errors can easily be made. This causes bugs, which leads to software appearing later and being more expensive. Michiel Helvensteijn, a PhD student from CWI and the Leiden Institute of Advanced Computer Science, studied how to prevent these kinds…

Matthijs van Leeuwen of the Leiden Institute of Advanced Computer Science develops methods to make computer models interactive. With interactive models, experts can combine information from raw data with their own knowledge to make predictions more accurate. 'In this way we hope to build models that…

Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…

In April 2018, Melanie Fink was elected as a member of the Coordinating Committee of the ESIL Interest Group ‘The EU as a Global Actor’. For the next four years, she will work in that function alongside Christine Kaddous (University of Geneva), Anne Thies (University of Reading), and Ramses Wessel (University…

After 41 years, Meindert Danhof, Professor of Pharmacology, is leaving the Leiden Academic Centre for Drug Research on 31 March. A symposium in his honour, prior to his farewell lecture, will show what has been achieved in this period. Danhof takes a look back on his career.

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

Mechanical interactions between cells and their environment play an important role in many biological processes.

Claire Vergerio, political scientist at Leiden University, has been awarded a VENI grant by Dutch research organisation NWO. This will allow her to conduct an in-depth analysis of the legal rights and duties of non-state actors involved in warfare. The aim is to tackle some persistent blindspots in…

On 20 April 2017 Jorrit Rijpma, Eugenio Cusumano, and Melanie Fink organise a Workshop to discuss the legal and policy implications of the surge in privately conducted search and rescue operations in the Central Mediterranean. The Workshop takes place in cooperation between the Law School and the Faculty…

The Centro de Estudos Internacionais at Instituto Universitário de Lisboa (ISCTE-IUL) will host the

This study aims to make a practical contribution to a new understanding and use of 3D reconstructions, namely as ‘laboratories’ to test hypotheses and visualize, evaluate and discuss alternative interpretations.

Assistant Professor Vedran Dunjko and his team received a gift from Google to support their quantum research. The research focuses on whether quantum computers can provide new ways of understanding the mysteries of high-energy physics.

Promotor: Prof.dr. J. Zaanen, A. Parnachev

On Thursday 28 January 2016, Prof. Carsten Stahn contributed to the OPCW Sub-Working Group on Non-State Actors, together with Professors Andrew Clapham (Geneva) and Dapo Akande (Oxford), in the presence of the Ahmet Üzümcü, Director-General of the OPCW.

Dave R. Stikkolorum, Michel R.V. Chaudron, Oswald de Bruin won the Best Paper Award of the Model Gamification Contest at the ACM/IEEE Models 2012 Conference for their paper: The Art Of Software Design, a Video Game for Learning Design Principles.

Can we establish a new quality control system for herbal medicines that is based on bioactivity rather than a few abundant chemicals?

On Thursday 25 and Friday 26 October 2018, the Europa Institute organized a conference within the framework of ‘Interaction between Legal Systems (ILS): Policing the High Seas’ and in cooperation with four Interest Groups of the European Society of International Law. The event brought together representatives…

A review of Elke Devroe's participation in the European Society of Criminology of 2016 : The first conference of the European Society of Criminology was held in 2000 in Lausanne. Now, 16 years later and lots of new ESC-members later, the 16th Annual conference of the European Society of Criminology…

The Grotius Centre for International Legal Studies, in collaboration with the ESIL Interest Group on International Criminal Justice and the Journal of International Criminal Justice (JICJ, OUP), is pleased to invite public international scholars, students and practitioners to attend a conference that…

Cosmologists have many possible models for the Universe, of which only one can be true. A new flowchart will eliminate some of them when two specific Universe features are accurately measured. Publication in Physical Review D on 7 November.

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

Professor Carlo Beenakker has been awarded a FOM Projectruimte subsidy to build a theoretical model of a majorana gun, a very promising instrument for quantum computers.

On 3 June 2016, Prof. Carsten Stahn participated in a Panel at the Graduate Institute on International and Development Studies in Geneva on accountability as a common goal between The Hague and Geneva.

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

The main methodological aspects of the use of stepwise LCA estimators under different circumstances.

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

Experts from several disciplines have raised concerns about the use of seemingly precise models to guide policies in matters as complex as the current Covid-19 pandemic. 22 scholars wrote down five principles on how to responsibly use scientific models. This comment was published in Nature on 24 June…