Systems Pharmacology
Key publications
Key publications of the Systems Pharmacology group
- Betts A., Keunecke A., van Steeg T.J., van der Graaf P.H., Avery L.B., Jones H., Berkhout J., Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach, mAbs 2018.
- van Esdonk M.J., van Zutphen E.J.M., Roelfsema F., Pereira A.M., van der Graaf P.H., Biermasz N.R., Stevens J., Burggraaf J., How are growth hormone and insulin-like growth factor-1 reported as markers for drug effectiveness in clinical acromegaly research? A comprehensive methodologic review, Pituitary 2018.
- Snowden T.J., van der Graaf P.H., Tindall M.J., Model reduction in mathematical pharmacology: Integration, reduction and linking of PBPK and systems biology models, J Pharmacokinet Pharmacodyn. 2018.
- van den Brink W.J., Hankemeier T., van der Graaf P.H., de Lange E.C.M., Bundling arrows: improving translational CNS drug development by integrated PK/PD-metabolomics, Expert Opin Drug Discov 2018.
- Schulthess P., Post T.M., Yates J., van der Graaf P.H., Frequency-Domain Response Analysis for Quantitative Systems Pharmacology Models, CPT Pharmacometrics Syst Pharmacol. 2017.
- Gosset J.R., Beaumont K., Matsuura T., Winchester W., Attkins N., Glatt S., Lightbown I., Ulrich K., Roberts S., Harris J., Mesic E., van Steeg T., Hijdra D., van der Graaf P.H., A cross-species translational pharmacokinetic-pharmacodynamic evaluation of core body temperature reduction by the TRPM8 blocker PF-05105679, Eur J Pharm Sci. 2017; 109S: S161-S167.
- Ribba B., Grimm H.P., Agoram B., Davies M.R., Gadkar K., Niederer S., van Riel N., Timmis J., van der Graaf P.H., Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation, CPT Pharmacometrics Syst Pharmacol. 2017; 6(8): 496-498.
- Benson N., van der Graaf P.H., Peletier L.A., Use of mathematics to guide target selection in systems pharmacology; application to receptor tyrosine kinase (RTK) pathways, Eur J Pharm Sci. 2017; 109S: S140-S148.
- Kantae V., Krekels E.H., Ordas A., González O., van Wijk R.C., Harms A.C., Racz P.I., van der Graaf P.H., Spaink H.P., Hankemeier T., Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude, Zebrafish. 2016; 13(6): 504-510.