Leiden Academic Centre for Drug Research
The Division of Toxicology of the LACDR has three major research areas: drug safety sciences and cancer drug target discovery, and additionally Computational Biology. Our research and teaching activities are strongly integrated around these topics.
Research Theme: Drug Safety Sciences
Adverse drug reactions are often poorly understood and difficult to predict. This represents a major pitfall in the drug development pipeline.
Projects corresponding to Drug Safety Sciences:
- Next generation human IPSC-derived reporter systems for image-based analysis of drug adversity
- Integrated omics approaches for systems understanding of adverse outcome pathways
- High throughput microscopy for cellular adaptive stress response pathways in drug adversity
- Mathematical modelling of adverse outcome pathways
Research Theme: Cancer Drug Target Discovery
In this research theme we focus on unraveling the mechanisms of cancer drug resistance and the mechanisms of metastasis in order to develop optimal candidate drugs targets.
Projects corresponding to Cancer Drug Target Discovery:
- Cell adhesion signaling: dynamics, migration, and metastasis
- Discovery of metastasis promoting candidate drug targets
- Computational modeling of tumor growth and metastasis, and the role of the immune system in tumor destruction
- Unraveling cancer drug resistance mechanisms
Research Theme: Computational Biology
In this research-theme we aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.
Projects corresponding to Computational Biology: