The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.
- Elizabeth (Liesbeth) de Lange
We mostly focus on the central nervous system (CNS), and through the use of state-of-the-art quantitative animal models we are able to obtain dynamical multiple level systems information from plasma and CNS compartments, under different conditions.
Connection with other research
- Predictive pharmacology
- The impact of drug-target binding kinetics on in vivo drug effects
- Prediction of CNS target site pharmacokinetics in humans
- Fingerprint biomarker analysis and modeling for disease progression stage diagnostics in Alzheimer's Disease
- Integration of PKPD modelling and metabolomics of the dopaminergic system
- Assessment of the impact of in vivo drug-target binding kinetics on local drug concentrations
- Towards a 3D brain drug distribution model
- Development of a QSP model for the prediction of intestinal/colonic drug distribution and efficacy of COX inhibitors targeting colorectal cancer