Microbial Biotechnology & Health
In the research programme Microbial Biotechnology & Health we perform state-of-the-art research in the field of biotechnology and microbial sciences.
- Gilles van Wezel
We are a diverse group of microbiologists who seek to understand the structure and function of microbes at all levels of biological organisation, from communities, through development, to cellular structures and molecules at atomic resolution. Research in the Microbial Biotechnology & Health cluster is organised in four core research areas.
Microbial Evolution & Ecology (MEE)
We investigate how microbes sense and respond to their environment and interact with other organisms. This includes elucidating the triggers and cues that elicit cryptic biosynthetic pathways for bioactive natural products.
Antibiotics & Anticancer Compounds (AAC)
We apply genomics and metabolomics technologies to discover new bioactive natural products, in particular antibiotics and anticancer compounds, and unravel the regulatory networks and biosynthetic pathways required for their production.
Microbial Cell Biology & Development (MCB&D)
We make important contributions to unravel the processes controlling cellular morphogenesis, growth, development and virulence, and visualise cellular structures and components from cellular level to atomic resolution.
Microbial Cell Factories (MCF)
We develop strain-design technologies based on biological understanding, and apply this to optimise microbes as cell factories for bioactive molecules and industrial enzymes.
Connection with other research
- Microbial Biotechnology & Health
- Less is more: reduced mycelial heterogeneity for improved production of enzymes and antibiotics
- Quest for new antibiotics
- Novel approaches to develop filamentous micro-organisms for enzyme production (FILAZYME)
- Heterogeneity in spores of food spoilage fungi
- Cryo-EM of cholera infection
- Improving the filamentous fungus Aspergillus niger as cell factory for starch degrading enzymes
- Microbial Chemotaxis
- Cell architecture and pathways for parallel secretion in the filamentous fungus Aspergillus niger
- Efficient targeting of the Trichoderma genome for industrial protein engineering
- Functions of autophagy in the filamentous fungus Aspergillus niger
- Fungal Chitosans from Fermentation Mycelia for Plant Biostimulants (FunChi)
- Regulation of enzyme production in fungal cell factories
- Cell Wall Dynamics in Aspergillus niger
- Horizontal gene transfer and spreading of biosynthetic gene clusters and antimicrobial resistance
- Anticancer compounds from actinomycetes
- Plant-microbe interactions
- Regulatory networks in Streptomyces
- Harnessing the soil microbiome for improved stress tolerance in crop plants