Research output

• A bioorthogonal chemistry approach to the study of biomolecules in their ultrastructural cellular context

  Dissertation

  • Science
    • Leiden Institute of Chemistry (LIC)
    • Bio-organic Synthesis

  

• Iminosugars as glucosylceramide processing enzymes inhibitors: design, synthesis and evaluation

  Dissertation

  • Science
    • Leiden Institute of Chemistry (LIC)
    • Fundamental Research in Chemical Biology
    • Bio-organic Synthesis

  

• Bioorthogonal Antigens

  Dissertation

  • Science
    • Leiden Institute of Chemistry (LIC)
    • Fundamental Research in Chemical Biology
    • Bio-organic Synthesis

  

• Design and development of conformational inhibitors and activity-based probes for retaining glycosidases

  Dissertation

  • Science
    • Leiden Institute of Chemistry (LIC)
    • Fundamental Research in Chemical Biology
    • Bio-organic Synthesis

  

• Discovery and development of inhibitors selective for human constitutive proteasome and immunoproteasome active sites

  Dissertation

  • Science
    • Leiden Institute of Chemistry (LIC)
    • Fundamental Research in Chemical Biology
    • Bio-organic Synthesis

  

• Synthesis of well-defined ADP-Ribosylated biomolecules

  Dissertation

  • Science
    • Leiden Institute of Chemistry (LIC)
    • Bio-organic Synthesis

  

• Development of kinase inhibitors and activity-based probes

  Dissertation

  • Science
    • Leiden Institute of Chemistry (LIC)
    • Bio-organic Synthesis

  

• 1,2-cis-glycosylations: method development and synthesis of complex oligosaccharides

  Dissertation

  • Science
    • Leiden Institute of Chemistry (LIC)
    • Bio-organic Synthesis

  

• Synthesis of phosphodiester-containing bacterial cell wall components: teichoic acids, capsular polysaccharides and phosphatidyl glycerol analogues

  Dissertation

  • Science
    • Leiden Institute of Chemistry (LIC)
    • Fundamental Research in Chemical Biology
    • Bio-organic Synthesis

  

• Activity-based protein profiling of glucosidases, fucosidases and glucuronidases

  Dissertation

  • Science
    • Leiden Institute of Chemistry (LIC)
    • Fundamental Research in Chemical Biology
    • Bio-organic Synthesis

  

• The use of activity based protein profiling to study proteasome biology

  Dissertation

  • Science
    • Leiden Institute of Chemistry (LIC)
    • Bio-organic Synthesis

  

• The synthesis of mannose-derived bioconjugates and enzyme inhibitors

  Dissertation

  • Science
    • Leiden Institute of Chemistry (LIC)
    • Bio-organic Synthesis

  

• Chemical tools to monitor and control human proteasome activities

  Dissertation

  • Science
    • Leiden Institute of Chemistry (LIC)
    • Fundamental Research in Chemical Biology
    • Bio-organic Synthesis

  

• Stereoelectronic and conformational effects in oxocarbenium, iminium and iminosugar ammonium ions

  Dissertation

  • Science
    • Leiden Institute of Chemistry (LIC)
    • Fundamental Research in Chemical Biology
    • Bio-organic Synthesis

  

• Cyclophellitol and its derivatives: synthesis and application as beta-glycosidase inhibitors

  Dissertation

  • Science
    • Leiden Institute of Chemistry (LIC)
    • Fundamental Research in Chemical Biology
    • Bio-organic Synthesis