Universiteit Leiden

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Lecture

LIBC SYLVIUS Lecture

Date
Thursday 20 October 2022
Time
Location
Zoom
Room
Pieter de la Court Building, Wassenaarseweg 52, room SB45

Balancing Brain Plasticity/Stability

Brain function is largely shaped by experience in early life, creating windows of both great opportunity and vulnerability. Our work has focused on the biological basis for such critical periods, identifying both “triggers” and “brakes” on plasticity. Strikingly, the maturation of particular inhibitory circuits is pivotal for the onset timing of these windows. Manipulations of their emergence can either accelerate or delay developmental trajectories regardless of chronological age. Notably, many neurodevelopmental disorders are linked to alterations in excitatory-inhibitory balance, suggesting shifted critical period timing as part of their etiology. Closure of critical periods in turn reflects an active process, rather than a purely passive loss of plasticity factors. Lifting these brakes allows the reopening of plastic windows later in life, but may also underlie instability in disease states. Thus, understanding how brain plasticity and stability are balanced throughout life offers new insight into mental illness and novel therapeutic strategies for recovery of function in adulthood.

If you would like to attend this lecture via zoom please register via e-mail to

LIBC
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