Universiteit Leiden

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LIBC Colloquium

Wednesday 10 November 2021
via Zoom
Pieter de la Courtgebouw, 5A23 & via Zoom

The role of the cannabinoid system in human fear learning

In 2002 a Nature paper by Marsicano et al. demonstrated that blocking the cannabinoid receptor 1 (CB1) genetically or pharmacologically strongly reduces the extinction of fear. This paper raised the question whether the endocannabinoid system may constitute a mechanism behind pathological fear in humans and/or a route to treat anxiety disorders. The number of papers on this topic sky-rocketed, but very few actually studied the relationship between the cannabinoid system and fear extinction in humans. In this talk, I will present the line of research in my lab on this topic, starting with administration of THC in healthy volunteers and ending with a randomized controlled trial with cannabidiol to augment cognitive behavior therapy in phobic disorders. In addition, important impediments for progress in this field will be discussed.

If you would like to attend this lecture via zoom please register via e-mail to

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