- Wednesday 10 November 2021
- via Zoom
- Pieter de la Courtgebouw, 5A23 & via Zoom
The role of the cannabinoid system in human fear learning
In 2002 a Nature paper by Marsicano et al. demonstrated that blocking the cannabinoid receptor 1 (CB1) genetically or pharmacologically strongly reduces the extinction of fear. This paper raised the question whether the endocannabinoid system may constitute a mechanism behind pathological fear in humans and/or a route to treat anxiety disorders. The number of papers on this topic sky-rocketed, but very few actually studied the relationship between the cannabinoid system and fear extinction in humans. In this talk, I will present the line of research in my lab on this topic, starting with administration of THC in healthy volunteers and ending with a randomized controlled trial with cannabidiol to augment cognitive behavior therapy in phobic disorders. In addition, important impediments for progress in this field will be discussed.
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