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CCLS Webinar: Detecting complexities in a scrambled genome through spacial graphs

Thursday 18 March 2021

Detecting complexities in a scrambled genome through spacial graphs

DNA rearrangement is a process found on both developmental and evolutionary scale. The process itself and the molecular shape at the time of the rearrangement can be modeled through 4-regular graphs.  These graph models are illustrated through the rearrangement processes in a well studied ciliate species Oxytricha trifallax where DNA recombination is observed on a massive scale.  Our studies show gene segments that recombine during DNA rearrangement processes may be organized on the chromosome in a variety of ways. They can overlap, interleave or one may be a subsegment of another. We use colored directed graphs to represent contigs containing rearranged segments where edges represent recombining segment organization. Using graph properties we associate a point in a higher dimensional Euclidean space to each graph such that cluster formations and analysis can be performed with various methods. The analysis shows some emerging graph structures indicating that segments of a single gene can interleave, or even contain,  all of the segments from several other genes in between its segments.

For a link to the meeting, please contact Chris Flinterman.

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