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Top Lectures June: Benjamin van Soldt

  • Dr. Benjamin van Soldt
Thursday 11 June 2020
This lecture will be held online

Be welcome at the Top Lectures from the Institute Biology Leiden! Every month researchers at the IBL invite (inter)national speakers to give a masterclass to students and hold a public accessible lecture.

The programme is as follows:

  • 15.00 - Top Lecture by Benjamin van Soldt
  • 16.00 - Discussion with MSc students
  • 17.00 - End

Your host for this edition is Professor of Animal Development Michael Richardson. He invited Benjamin van Soldt from Columbia University, New York (USA) to talk about: Determinants of proximal-distal patterning of the mouse lung epithelium during development.


Development of the branched airway tree of the lung initiates with the patterning of the nascent lung buds into proximal airway and distal tip compartments, that ultimatley give rise to airways and alveoli, respectively. However, lineage tracing experiments have demonstrated that the epithelial progenitor cells that reside in the distal tip compartment give rise to all cell types of the lung epithelium, including airway epithelial cell types. This contrast is explained by a fate transition event that occurs during establishment of the branched airway tree of the lung, where distal tip epithelial progenitor cells may exit the distal tip compartment, and subsequently acquire a proximal airway cell fate instead. However, this transition event remains little understood. In this talk I will share our first insights into the molecular determinants of proximal-distal patterning and fate transition during lung development.

How to join?

Please use this link to join the Live Room: https://smart.newrow.com/#/room/itb-403

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