Lecture

FRESH Lecture: (Photo)-catalysts based on surface functionalized laccases

• Dr. Thierry Tron (Aix Marseille Université)

Date

Thursday 31 January 2019

Time

16:30 - 17:30

Location

Gorlaeus Building
Einsteinweg 55
2333 CC Leiden

Room

GM4.13

Abstract

Laccases are well known biocatalysts with great robustness, high oxidation power and substrate versatility.^[1] Their unique set of copper centres - a near-surface located mononuclear type 1 and an embedded tri-nuclear cluster (TNC) made of a type 2 and a binuclear type 3 - couple the oxidation of substrates (organic or metal ions) to dioxygen reduction.^[2] We shape new catalysts based on oriented functionalizations of a laccase surface with different “plug-ins”.

From our initial demonstrations on bi-molecular systems - a sensitizer/laccase system coupling the light driven four-electron reduction of dioxygen to water^[3] to the photo-oxidation of styrene^[4] or a Pd(II)/ laccase system competent for the aerobic oxidation of alcohol in mild conditions^[5] - we will present our latest architectures based on the oriented grafting of the enzyme surface.^{[6 ,7]}

Prospects on olefin oxidation catalysts and laccase functionalized electrode materials will be discussed.

References

1. T. Tron, in Encyclopedia of Metalloproteins, Springer, New York, 1066 (2013)
2. E. Solomon, U. Sundaram, T. Machonkin, Chem. Rev., 96, 2563 (1996)
3. T. Lazarides et al., J. Am. Chem. Soc. 135, 3095 (2013)
4. L. Schneider et al., Chem. Sus. Chem., 8, 3048 (2015)
5. Y. Mekmouche et al., Chem. Sci., 6,1247 (2015)
6. N. Lalaoui et al., ACS Catalysis, 6, 1894 (2016)
7. V. Robert et al., Chem. Plus Chem., 82, 607 (2017)