Lecture
FRESH Lecture: (Photo)-catalysts based on surface functionalized laccases
- Dr. Thierry Tron (Aix Marseille Université)
- Date
- Thursday 31 January 2019
- Time
- Location
- Gorlaeus Building
Einsteinweg 55
2333 CC Leiden - Room
- GM4.13
Abstract
Laccases are well known biocatalysts with great robustness, high oxidation power and substrate versatility.[1] Their unique set of copper centres - a near-surface located mononuclear type 1 and an embedded tri-nuclear cluster (TNC) made of a type 2 and a binuclear type 3 - couple the oxidation of substrates (organic or metal ions) to dioxygen reduction.[2] We shape new catalysts based on oriented functionalizations of a laccase surface with different “plug-ins”.
From our initial demonstrations on bi-molecular systems - a sensitizer/laccase system coupling the light driven four-electron reduction of dioxygen to water[3] to the photo-oxidation of styrene[4] or a Pd(II)/ laccase system competent for the aerobic oxidation of alcohol in mild conditions[5] - we will present our latest architectures based on the oriented grafting of the enzyme surface.[6 ,7]
Prospects on olefin oxidation catalysts and laccase functionalized electrode materials will be discussed.
References
- T. Tron, in Encyclopedia of Metalloproteins, Springer, New York, 1066 (2013)
- E. Solomon, U. Sundaram, T. Machonkin, Chem. Rev., 96, 2563 (1996)
- T. Lazarides et al., J. Am. Chem. Soc. 135, 3095 (2013)
- L. Schneider et al., Chem. Sus. Chem., 8, 3048 (2015)
- Y. Mekmouche et al., Chem. Sci., 6,1247 (2015)
- N. Lalaoui et al., ACS Catalysis, 6, 1894 (2016)
- V. Robert et al., Chem. Plus Chem., 82, 607 (2017)