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PhD Defence

Somatic POLE exonuclease domain mutations in endometrial cancer – Insights into the biology of POLE-mutant tumors

  • I.C. van Gool
Thursday 14 June 2018
Academy Building
Rapenburg 73
2311 GJ Leiden


Endometrial cancer arises from the epithelial lining of the uterus, called endometrium. Recently, more insights were gained in the molecular genetic basis of this type of cancer. This thesis describes research into one specific subtype of endometrial cancer, in which the tumourcells contain a mutation in the gene for DNA polymerase epsilon (POLE). This subtype is characterized by a much more favourable prognosis for patients. The aim of the research was to gain insights in how these POLE-mutations cause this favourable effect. The findings help bringing 'personalized therapy' a step closer, not only for endometrial cancer but also for colorectal cancer and other malignancies. 


  • Prof. V.T.H.B.M. Smit
  • Prof. C.L. Creutzberg


PhD defences are free; you do not have to register.

PhD dissertations

PhD dissertations by Leiden PhD students are available digitally after the defence through the Leiden Repository, that offers free access to these PhD dissertations. Please note that in some cases a dissertation may be under embargo temporarily and access to its full-text version will only be granted later.

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