Universiteit Leiden

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Lecture

MCBIM Colloquium: Selective oxidation catalysts inspired in non heme iron dependent oxygenases

  • Dr. Miquel Costas (University of Girona)
Date
Wednesday 28 February 2018
Time
Location
Gorlaeus Building
Einsteinweg 55
2333 CC Leiden
Room
DM1.09

Abstract

Biologically inspired catalysts are currently explored with the aim to produce selective oxidation reactions. The quest for catalytic methodologies that provide novel reactivities and selectivities that could complement those attained with traditional oxidants, or that could represent a more efficient alternative constitute major reasons of interest for this approach1-3.

Towards this end, iron and manganese coordination complexes ligated to amine and oxygen containing functionalities, and that could be viewed as a minimalistic model of iron coordination sites in non heme iron dependent oxygenases, are employed as catalysts for the oxidation of organic substrates. By control of their structure and electronic properties, catalysts have been designed by our research team that engage in controlled O-O lysis of H2O2 to form highly electrophilic high valent metal-oxo species that are finally responsible for enzyme-like selective oxidation chemistry4.

Principles of catalyst design and use of these catalysts in selective C-H and C=C oxidation reactions, and reaction intermediates involved in these reactions5 will be discussed.

References

1. L. Que, W.B. Tolman, Nature 2008, 455, 333.

2. G. Olivo, O. Cussó, M. Costas, Chem. As. J. 2016, 11, 3148.

3. G. Olivo, O. Cussó, M. Borrell, M. Costas, J. Biol. Inorg. Chem., 2017, 22, 425.

4. a) O. Cussó, M. Schiafanelly, X. Ribas, R. Klein Gebbink, M. Costas, J. Am. Chem. Soc. 2016, 138, 2732.

b) O Cussó, M.W. Giuliano, X. Ribas, S.J. Miller, M. Costas, Chem. Sci. 2017, 8, 3660.

c) M. Milan, M. Bietti, M. Costas, ACS Central Sci., 2017, 3, 196.

d) M. Borrell, M. Costas, J. Am. Chem. Soc. 2017139, 12821.

5. a) J. Serrano-Plana, W. Oloo, L. Acosta-Rueda, K. Meier, B. Verdejo, E. Garcia-España, M.G. Basallote, E. Münck, L. Que, Jr., A. Company, M. Costas, J. Am. Chem. Soc., 2015, 137, 15833.

b) O. Cussó, J. Serrano, M. Costas, ACS Catal. 20177, 5046.

c) J. Serrano et al. Submitted

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