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PhD Defence

Catecholamine function, brain state dynamics, and human cognition

  • R.L. van den Brink
Tuesday 7 November 2017
Academy Building
Rapenburg 73
2311 GJ Leiden


The locus coeruleus (LC) is a nucleus in the brainstem, and projects widely to the forebrain where it releases norepinephrine (NE). Catecholamines such as NE do not have a unitary effect on their target neurons, but instead influence the function of other neurotransmitters, a process that is known known as neuromodulation. By virtue of the LC’s wide projection profile and the neuromodulatory properties of NE, the LC-NE system profoundly influences neural firing characteristics and associated cognitive processes. The work presented in this thesis addresses the role of the LC-NE system in various aspects of human cognition, and the modulation of brain state.


  • Prof. S.T. Nieuwenhuis


PhD defences are free; you do not have to register.

PhD dissertations

PhD dissertations by Leiden PhD students are available digitally after the defence through the Leiden Repository, that offers free access to these PhD dissertations. Please note that in some cases a dissertation may be under embargo temporarily and access to its full-text version will only be granted later.

Press contact

Inès van Arkel, Scientific Communications Adviser, Leiden University
+31 71 527 3282

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