LCN2 Seminar: The hyperexcitable migraine brain
- Thijs Perenboom
- 27 October 2017
- Gorlaeus Building
2333 CC Leiden
- Science club (Gorlaeus)
About the talk
Speaker: Thijs Perenboom (LUMC)
Title: The hyperexcitable migraine brain
Migraine is associated with altered processing of sensory input that may be due to cortical hyperexcitability. The visual cortex is believed to be particularly affected, based on the hypersensitivity of migraine patients to light and occurrence of visual aura symptoms preceding the headache phase in a proportion of migraine patients. Tracking brain excitability over time might be an approach to predict an impending migraine attack.
Several methods exist to measure excitability of the cortex, based on perturbing the brain using e.g. visual stimulation or transcranial magnetic stimulation. Recordings of the brain’s response using electrodes on the scalp provide amplitude and phase information of the evoked activity. Also resting state brain activity contains information about excitability, mostly in the connectivity between brain regions. In this talk, I will describe multiple methods we employed to study altered cortical excitability in migraine and their potential clinical application.
About the LCN2 seminar
This talk is part of a series of seminars organized within an ongoing scientific initiative called "Leiden Complex Networks Network (LCN2), which aims at bringing together scientists with a common interest in both theoretical models and empirical analyses of complex networks and random graphs. The LCN2 community that is being established shares the approach of using networks for describing real-world complex systems and aims at developing related analytical and numerical methods, while also being open to other research approaches for studying complex systems. The talks are designed for a broad audience, allowing for constructive exchanges of ideas between scientists from different disciplines. After and during the talk, drinks and snacks are provided.