Universiteit Leiden

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Chemical Biology Lecture

  • Dr. Vicente Verez-Bencomo (Finlay Institute for Vaccine Research, Havana)
Friday 27 January 2017
Gorlaeus Building
Einsteinweg 55
2333 CC Leiden

Vaccines against bacterial pathogens: The role of synthetic carbohydrate chemistry

The molecular recognition is on the basis of several biological processes. Natural and synthetic glyco-conjugates play a pivotal role in understanding that principle and also in their use in medicine. In the last 20 years, we have developed a diagnostic test for leprosy [1], an anti-human monoclonal antibody as serotyping reagent [2] and a glyco-conjugate vaccine against Haemophilus influenzae type b [3]. This vaccine (called Quimi-Hib) was the first one containing a synthetic antigen providing evidence of clinical efficacy. Quimi-Hib is actually prequalified by WHO and more than 34 million doses of this synthetic glyco-conjugate vaccine have been already distributed in several countries. Other carbohydrate-protein conjugates are under development against S. pneumoniae [4] and N. meningitides. In addition Very Small Size Particles have been explored as a potent adjuvant in cancer treatment.

[1] Carbohydr. Res, 1988, 183:175
[2] Carbohydrate Letters, 1999, 3:369
[3] Science, 2004, 305:522
[4] Vaccine, 2014, 32:5266

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