Universiteit Leiden

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Chemical Biology Lecture: Dr. Tom Wennekes

  • Dr. Tom Wennekes
Thursday 26 May 2016
Gorlaeus Building
Einsteinweg 55
2333 CC Leiden
Havinga Lecture Hall

Getting a Grip on Glycan-mediated Host-Guest Interactions with Chemical Glycobiology

All cells of all living organisms are covered by a layer of highly complex carbohydrates, called the glycocalyx. In multicellular organisms these carbohydrates, which are also known as glycans, are essential mediators of a wide range of biological processes such as protein folding, cell signaling and immune.

Microbes are also covered by a thick layer of glycans, and these structures and their interacting proteins are often of critical importance in both symbiotic and pathogenic host-guest interactions. In my research group we use a chemical biology approach to unravel this glycobiology. An array of tailor-made molecular tools are used to profile and perturb these interactive events between organisms at the glycocalyx interface.

In this seminar I will provide a brief introduction to the following four chemical glycobiology research projects in my group: 1) developing a mechanism-based inhibitors for the influenza virus neuraminidase; 2) developing multivalent inhibitors for cholera toxin; 3) capture and growth of probiotic gut microbes on glycan- functionalized porous aluminum oxide culturing chips and 4) metabolic labelling of plant and microbial glycans.

[1] S.A. van den Berg, H. Zuilhof, T. Wennekes, Macromolecules 2016, Macromolecules, 2016, 49 (6), 2054–2062.
[2] J. Hoogenboom; H. Zuilhof; T. Wennekes, Organic Letters 2015, 22, 5550-5553.
[3] A. Debrassi, W.M. de Vos, H. Zuilhof, T. Wennekes, Book chapter in Carbohydrate Nanotechnology, Wiley & Sons, 2015 (ISBN: 978-1-118-86053-3).
[4] A. Debrassi, E. Roeven, S. Thijssen, L. Scheres, W.M. de Vos, T. Wennekes, H. Zuilhof, Langmuir 2015, 31 (20), 5633-5644.
[5] J. H. Kim, R. Resende, T. Wennekes, H. M. Chen, N. Bance, S. Buchini, A. G. Watts, P. Pilling, V. A. Streltsov, M. Petric, R. Liggins, S. Barrett, J. L. McKimm-Breschkin, M. Niikura, S. G. Withers, Science 2013, 340, 71-75.
[6] J. Garcia-Hartjes, S. Bernardi, C. A. G. M. Weijers, T. Wennekes, M. Gilbert, F. Sansone, A. Casnati, H. Zuilhof, Organic Biomolecular Chemistry 2013, 11, 4340-4349.


Profile of Dr. Tom Wennekes

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