Chemical Biology Lecture: Dr. Tom Wennekes
- Dr. Tom Wennekes
- Thursday 26 May 2016
2333 CC Leiden
- Havinga Lecture Hall
Getting a Grip on Glycan-mediated Host-Guest Interactions with Chemical Glycobiology
All cells of all living organisms are covered by a layer of highly complex carbohydrates, called the glycocalyx. In multicellular organisms these carbohydrates, which are also known as glycans, are essential mediators of a wide range of biological processes such as protein folding, cell signaling and immune.
Microbes are also covered by a thick layer of glycans, and these structures and their interacting proteins are often of critical importance in both symbiotic and pathogenic host-guest interactions. In my research group we use a chemical biology approach to unravel this glycobiology. An array of tailor-made molecular tools are used to profile and perturb these interactive events between organisms at the glycocalyx interface.
In this seminar I will provide a brief introduction to the following four chemical glycobiology research projects in my group: 1) developing a mechanism-based inhibitors for the influenza virus neuraminidase; 2) developing multivalent inhibitors for cholera toxin; 3) capture and growth of probiotic gut microbes on glycan- functionalized porous aluminum oxide culturing chips and 4) metabolic labelling of plant and microbial glycans.
 S.A. van den Berg, H. Zuilhof, T. Wennekes, Macromolecules 2016, Macromolecules, 2016, 49 (6), 2054–2062.
 J. Hoogenboom; H. Zuilhof; T. Wennekes, Organic Letters 2015, 22, 5550-5553.
 A. Debrassi, W.M. de Vos, H. Zuilhof, T. Wennekes, Book chapter in Carbohydrate Nanotechnology, Wiley & Sons, 2015 (ISBN: 978-1-118-86053-3).
 A. Debrassi, E. Roeven, S. Thijssen, L. Scheres, W.M. de Vos, T. Wennekes, H. Zuilhof, Langmuir 2015, 31 (20), 5633-5644.
 J. H. Kim, R. Resende, T. Wennekes, H. M. Chen, N. Bance, S. Buchini, A. G. Watts, P. Pilling, V. A. Streltsov, M. Petric, R. Liggins, S. Barrett, J. L. McKimm-Breschkin, M. Niikura, S. G. Withers, Science 2013, 340, 71-75.
 J. Garcia-Hartjes, S. Bernardi, C. A. G. M. Weijers, T. Wennekes, M. Gilbert, F. Sansone, A. Casnati, H. Zuilhof, Organic Biomolecular Chemistry 2013, 11, 4340-4349.