Universiteit Leiden

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Lecture

Chemical Biology Lecture

  • Prof. Andreas Marx (Universität Koblenz)
Date
Thursday 21 July 2016
Time
Location
Gorlaeus Building
Einsteinweg 55
2333 CC Leiden
Room
Havinga Lecture Hall

Synthetic tools for Biopolymer Synthesis and Recognition

Andreas Marx is Professor of Organic Chemistry and Cellular Chemistry at the University of Konstanz. He is one of the word-leading experts in the chemistry and chemical biology of nucleic acids. Prof. Marx has made significant contributions to the development of chemical tools for studies of nucleic acids and related structures.

Abstract

In eukaryotes, proteins are often chemically modified during their “life span”. These posttranslational modifications represent an information level that is beyond the genetic code and varies with time and cellular location to allow cells to adjust protein activities to changes in intra- and extracellular conditions. Here, the protein-based modification ubiquitin and nucleic acid-reminiscent modification poly(ADP-ribose) are of particular interest for us. I will report on our recent results in studies of these biopolymers using synthetic tools.

Recent studies have highlighted the paramount importance of “non-standard” Watson-Crick nucleobases in DNA and RNA. I will report on our recent results in the aim to develop simplified systems that allow tracing of these of these rare nucleobases.

Marx Group

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