Universiteit Leiden

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This Week’s Discoveries | 23 February 2016

23 February 2016
This Week's Discoveries
Gorlaeus Laboratories
Einsteinweg 55
2333 CC Leiden
De Sitterzaal

First Lecture

Title: A set of chemical tools to visualize and control (immuno)proteasome activities-Fluorescent probes & inhibitors
Speaker Gerjan de Bruin (LIC)

Gerjan is a PhD student in the Bio-organic synthesis group at the LIC. He is fascinated by drug innovation. During his PhD research, he developed a suite of chemical tools to visualize and control the activity of the waste treatment plants of human cells: the proteasomes. These large protein complexes are therapeutic targets in the treatment of various cancers and autoimmune diseases. He was nominated by the LIC as Discoverer of the year 2015.

Second Lecture

Title: Exploring the ultrastructure of bacteria
Speaker: Ariane Briegel ( IBL and NeCEN)

As of December 2015, Ariane has been appointed professor of “Ultrastructural Biology” in the Microbial Biotechnology & Health cluster at IBL. Her expertise is in using electron cryotomography to study how microbes sense and respond to their environment. She will continue her earlier work that she started at CalTech on chemoreceptor arrays at the IBL and will pursue a new line of research to understand bacterial ultrastructure in native environments. So far, studies of bacterial ultrastructure have largely been limited to bacterial cells grown in liquid monocultures. But an increasing number of studies demonstrate that bacteria undergo radical morphological changes depending on environmental conditions.